Affinity and catalytic heterogeneity and metal-dependence of polyclonal myelin basic protein-hydrolyzing IgGs from sera of patients with systemic lupus erythematosus

2011 ◽  
Vol 24 (6) ◽  
pp. 960-974 ◽  
Author(s):  
Anna M. Bezuglova ◽  
Ludmila P. Konenkova ◽  
Boris M. Doronin ◽  
Valentina N. Buneva ◽  
Georgy A. Nevinsky
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Myelin Basic Protein ◽  
Lupus Erythematosus ◽  
Basic Protein ◽  
Systemic Lupus ◽  
Catalytic Heterogeneity

Anti-histone H1 IgGs from blood serum of systemic lupus erythematosus patients are capable of hydrolyzing histone H1 and myelin basic protein

2010 ◽  
Vol 23 (5) ◽  
pp. 495-502 ◽  
Author(s):  
Irina B. Magorivska ◽  
Rostyslav O. Bilyy ◽  
Anna M. Havrylyuk ◽  
Valentyna V. Chop'yak ◽  
Rostyslav S. Stoika ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Blood Serum ◽  
Myelin Basic Protein ◽  
Lupus Erythematosus ◽  
Basic Protein ◽  
Histone H1 ◽  
Systemic Lupus

Systemic lupus erythematosus: molecular cloning and analysis of recombinant monoclonal kappa light chain NGTA1-Me-pro with two metalloprotease active centers

2016 ◽  
Vol 12 (12) ◽  
pp. 3556-3566 ◽  
Author(s):  
Anna M. Timofeeva ◽  
Valentina N. Buneva ◽  
Georgy A. Nevinsky
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Myelin Basic Protein ◽  
Molecular Cloning ◽  
Light Chain ◽  
Lupus Erythematosus ◽  
Basic Protein ◽  
Kappa Light Chain ◽  
Systemic Lupus ◽  
Active Centers

Monoclonal light chain (NGTA1-Me-pro) possessing two alternative active centers with metalloprotease activities specifically recognizing only myelin basic protein (MBP) was obtained. NGTA1-Me-pro demonstrated two pH optima (A), two optimal concentrations of Me2+ions (B), and twoKmvalues for MBP.

Organized Intraglomerular Deposits in NZB Mouse Disease

1971 ◽  
Vol 29 ◽  
pp. 544-545
Author(s):  
Francis R. Comerford ◽  
Alan S. Cohen
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Antinuclear Antibodies ◽  
Human Systemic Lupus Erythematosus ◽  
Systemic Lupus ◽  
Glomerular Lesion ◽  
Ultrastructural Studies ◽  
Dense Deposits ◽  
Experimental Nephritis ◽  
Glomerular Lesions

Mice of the inbred NZB strain develop a spontaneous disease characterized by autoimmune hemolytic anemia, positive lupus erythematosus cell tests and antinuclear antibodies and nephritis. This disease is analogous to human systemic lupus erythematosus. In ultrastructural studies of the glomerular lesion in NZB mice, intraglomerular dense deposits in mesangial, subepithelial and subendothelial locations were described. In common with the findings in many examples of human and experimental nephritis, including many cases of human lupus nephritis, these deposits were amorphous or slightly granular in appearance with no definable substructure.We have recently observed structured deposits in the glomeruli of NZB mice. They were uncommon and were found in older animals with severe glomerular lesions by morphologic criteria. They were seen most commonly as extracellular elements in subendothelial and mesangial regions. The deposits ranged up to 3 microns in greatest dimension and were often adjacent to deposits of lipid-like round particles of 30 to 250 millimicrons in diameter and with amorphous dense deposits.

“Subcortical” cognitive impairment in patients with systemic lupus erythematosus

2000 ◽  
Vol 6 (7) ◽  
pp. 821-825 ◽  
Author(s):  
ELIZABETH LERITZ ◽  
JASON BRANDT ◽  
MELISSA MINOR ◽  
FRANCES REIS-JENSEN ◽  
MICHELLE PETRI
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Cognitive Impairment ◽  
Lupus Erythematosus ◽  
Systemic Lupus
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