Equilibrium and kinetic analysis of human interleukin-13 and IL-13 receptor alpha-2 complex formation

2012 ◽  
Vol 25 (3) ◽  
pp. 184-191 ◽  
Author(s):  
Eilyn R. Lacy
Keyword(s):  
Complex Formation ◽  
Kinetic Analysis ◽  
Receptor Alpha ◽  
Interleukin 13

Thermodynamic and kinetic analysis of Meisenheimer complex formation

1972 ◽  
Vol 37 (16) ◽  
pp. 2608-2611 ◽  
Author(s):  
J. H. Fendler ◽  
John W. Larsen
Keyword(s):  
Complex Formation ◽  
Kinetic Analysis

scholarly journals Interleukin-13 receptor alpha 2 cooperates with EGFRvIII signaling to promote glioblastoma multiforme

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Jennifer P. Newman ◽  
Grace Y. Wang ◽  
Kazuhiko Arima ◽  
Shou P. Guan ◽  
Michael R. Waters ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
Receptor Alpha ◽  
Interleukin 13

scholarly journals The association of the cytoplasmic domains of interleukin 4 receptor alpha and interleukin 13 receptor alpha 2 regulates interleukin 4 signaling

2013 ◽  
Vol 9 (12) ◽  
pp. 3009 ◽  
Author(s):  
Allison-Lynn Andrews ◽  
Ida Karin Nordgren ◽  
Gemma Campbell-Harding ◽  
John W. Holloway ◽  
Stephen T. Holgate ◽  
...  
Keyword(s):  
Interleukin 4 ◽  
Cytoplasmic Domains ◽  
Receptor Alpha ◽  
Interleukin 13 ◽  
Interleukin 4 Receptor

scholarly journals Significance of interleukin-13 receptor alpha 2-targeted glioblastoma therapy

2014 ◽  
Vol 16 (10) ◽  
pp. 1304-1312 ◽  
Author(s):  
B. Thaci ◽  
C. E. Brown ◽  
E. Binello ◽  
K. Werbaneth ◽  
P. Sampath ◽  
...  
Keyword(s):  
Receptor Alpha ◽  
Interleukin 13

scholarly journals IL-4R alpha deficiency influences hippocampal-BDNF signaling pathway to impair reference memory

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
T. M. Brombacher ◽  
I. Berkiks ◽  
S. Pillay ◽  
M. Scibiorek ◽  
B. O. Moses ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Inflammatory Cytokines ◽  
Chain Complex ◽  
Reference Memory ◽  
Spatial Task ◽  
Interleukin 4 ◽  
Receptor Alpha ◽  
Interleukin 13 ◽  
Interleukin 4 Receptor ◽  
Deficient Mice

Abstract Like pro-inflammatory cytokines, the role of anti-inflammatory cytokines in both learning and memory has been investigated, revealing beneficial effects for both interleukin-4 and interleukin-13 via the common interleukin-4 receptor alpha chain complex. In this study, using the Morris water maze spatial task for cognition, we compared interleukin-4 receptor alpha- deficient mice and their ligands interleukin-4/ interleukin-13 double deficient mice, on a Balb/c background. We demonstrate that while interleukin-4/ interleukin-13 double deficient mice are significantly impaired in both learning and reference memory, interleukin-4 receptor alpha-deficiency impairs only reference memory, compared to the wild-type control mice. In order to better understand how interleukin-4 receptor alpha- deficient mice are able to learn but not remember, we investigated the BDNF/TrkB- and the ARC-signaling pathways. We show that interleukin-4 receptor alpha-deficiency disrupts activation of BDNF/TrkB- and ARC-signaling pathways during reference memory, while the pathway for spatial learning is spared.

Interleukin-13 Mediates Airways Hyperreactivity through the IL-4 Receptor-Alpha Chain and STAT-6 Independently of IL-5 and Eotaxin

2001 ◽  
Vol 25 (4) ◽  
pp. 522-530 ◽  
Author(s):  
Ming Yang ◽  
Simon P. Hogan ◽  
Peter J. Henry ◽  
Klaus I. Matthaei ◽  
Andrew N. J. McKenzie ◽  
...  
Keyword(s):  
Receptor Alpha ◽  
Alpha Chain ◽  
Interleukin 13 ◽  
Airways Hyperreactivity ◽  
Receptor Alpha Chain
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