Dorsal Lateral Plate Mesoderm Influences Proliferation and Differentiation of Hemopoietic Stem Cells Derived From Ventral Lateral Plate Mesoderm During Early Development of Xenopus laevis Embryos

1985 ◽  
Vol 38 (3) ◽  
pp. 415-427 ◽  
Author(s):  
James B. Turpen ◽  
Paula B. Smith
Keyword(s):  
Stem Cells ◽  
Xenopus Laevis ◽  
Early Development ◽  
Hemopoietic Stem Cells ◽  
Lateral Plate Mesoderm ◽  
Lateral Plate ◽  
Proliferation And Differentiation ◽  
Xenopus Laevis Embryos

scholarly journals Studies on the effect of deoxyadenosine on deoxycoformycin-treated myeloid and lymphoid stem cells

Blood ◽  
1982 ◽  
Vol 60 (4) ◽  
pp. 872-876
Author(s):  
MT Aye ◽  
JV Dunne ◽  
WC Yang
Keyword(s):  
Stem Cells ◽  
Adenosine Deaminase ◽  
Severe Combined Immunodeficiency ◽  
Immune Dysfunction ◽  
Model Systems ◽  
Hemopoietic Stem Cells ◽  
Combined Immunodeficiency ◽  
Proliferation And Differentiation ◽  
Immunodeficiency Disease ◽  
Severe Combined Immunodeficiency Disease

Adenosine deaminase (ADA) deficiency has been reported in association with severe combined immunodeficiency disease (SCID). The mechanism by which ADA deficiency causes immune dysfunction has been investigated in model systems to which the ADA inhibitor deoxycoformycin (dCf) had been added. Previously, we demonstrated that dCF did not prevent proliferation and differentiation of myeloid and lymphoid stem cells. We have now shown that addition of deoxyadenosine to dCf-containing cultures inhibited proliferation of hemopoietic stem cells. This inhibition was, however, equally effective for both normal myeloid and lymphoid stem cells. These findings suggest that other differences may exist between SCID myeloid and lymphoid stem cells to account for the relative sparing of myelopoiesis in SCID patients.

scholarly journals Satellite cells originate from the lateral plate mesoderm in Xenopus laevis

2010 ◽  
Vol 344 (1) ◽  
pp. 519
Author(s):  
Randy Daughters ◽  
Ying Chen ◽  
Jonathan M. Slack
Keyword(s):  
Xenopus Laevis ◽  
Satellite Cells ◽  
Lateral Plate Mesoderm ◽  
Lateral Plate

scholarly journals Quantitative proteomics of Xenopus laevis embryos: expression kinetics of nearly 4000 proteins during early development

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Liangliang Sun ◽  
Michelle M. Bertke ◽  
Matthew M. Champion ◽  
Guijie Zhu ◽  
Paul W. Huber ◽  
...  
Keyword(s):  
Xenopus Laevis ◽  
Early Development ◽  
Quantitative Proteomics ◽  
Kinetics Of ◽  
Xenopus Laevis Embryos ◽  
Expression Kinetics

scholarly journals Homeobox genes and connective tissue patterning

Development ◽  
1995 ◽  
Vol 121 (3) ◽  
pp. 693-705 ◽  
Author(s):  
G. Oliver ◽  
R. Wehr ◽  
N.A. Jenkins ◽  
N.G. Copeland ◽  
B.N. Cheyette ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Connective Tissue ◽  
Early Development ◽  
Molecular Mechanisms ◽  
Homeobox Genes ◽  
Lateral Plate Mesoderm ◽  
Lateral Plate ◽  
Tissue Patterning

In vertebrates, limb tendons are derived from cells that migrate from the lateral plate mesoderm during early development. While some of the developmental steps leading to the formation of these tissues are known, little is known about the molecular mechanisms controlling them. We have identified two murine homeobox-containing genes, Six 1 and Six 2, which are expressed in a complementary fashion during the development of limb tendons. Transcripts for both genes are found in different sets of phalangeal tendons. Six 1 and Six 2 also are expressed in skeletal and smooth muscle, respectively. These genes may participate in the patterning of the distal tendons of the limb phalanges by setting positional values along the limb axes.

Mesodermal subdivision along the mediolateral axis in chicken controlled by different concentrations of BMP-4

Development ◽  
1997 ◽  
Vol 124 (10) ◽  
pp. 1975-1984 ◽  
Author(s):  
A. Tonegawa ◽  
N. Funayama ◽  
N. Ueno ◽  
Y. Takahashi
Keyword(s):  
Early Development ◽  
Molecular Mechanisms ◽  
Lateral Plate Mesoderm ◽  
Tgf Beta ◽  
Presomitic Mesoderm ◽  
Lateral Plate ◽  
Chicken Embryos ◽  
Cos Cells ◽  
Low Level ◽  
High Level

Molecular mechanisms by which the mesoderm is subdivided along the mediolateral axis in early chicken embryos have been studied. When the presomitic mesoderm (medial mesoderm) was transplanted into the lateral plate, the graft was transformed into lateral plate tissue, indicating that the primitive somite was not fully committed and that the lateral plate has a cue for mesodermal lateralization. Since the lateral plate expresses a high level of BMP-4 mRNA, a member of the TGF-beta family, we hypothesized that it is the molecule responsible for the lateralization of the somite. To test this, we transplanted COS cells producing BMP-4 into the presomitic region. Those cells locally prevented the presomitic cells from differentiating into somites, converting them instead into lateral plate mesoderm, which was revealed by expression of cytokeratin mRNA, a marker for the lateral plate. The effect was dependent on the level of effective BMP-4: with a high level of BMP-4, the somite was transformed completely to lateral plate; with a low level, the somite formed but was occupied by the lateral somitic component expressing cSim 1, a marker for the lateral somite. These results suggest that different thresholds of effective BMP-4 determine distinct subtypes of the mesoderm as a lateralizer during early development.

Hyaluronan is synthesized by primitive hemopoietic cells, participates in their lodgment at the endosteum following transplantation, and is involved in the regulation of their proliferation and differentiation in vitro

Blood ◽  
2003 ◽  
Vol 101 (3) ◽  
pp. 856-862 ◽  
Author(s):  
Susan K. Nilsson ◽  
David N. Haylock ◽  
Hayley M. Johnston ◽  
Teresa Occhiodoro ◽  
Tracey J. Brown ◽  
...  
Keyword(s):  
Stem Cells ◽  
Striking Difference ◽  
Hemopoietic Stem Cells ◽  
Surface Adhesion ◽  
Developmentally Regulated ◽  
Hemopoietic Cells ◽  
Proliferation And Differentiation ◽  
A Cell

Abstract The localization of adult hemopoiesis to the marrow involves developmentally regulated interactions between hemopoietic stem cells and the stromal cell–mediated hemopoietic microenvironment. Although primitive hemopoietic cells exhibit a broad repertoire of adhesion molecules, little is known about the molecules influencing the site of cell lodgment within the marrow following transplantation. However, our recent studies indicate that hierarchically dependent patterns of migration of transplanted hemopoietic cells result in the retention of primitive cells within the endosteal and lineage-committed cells in the central marrow regions. Herein, we now demonstrate that these 2 subpopulations exhibit a striking difference in the expression of a cell surface adhesion molecule, with populations enriched for murine and human hemopoietic stem cells expressing the carbohydrate hyaluronic acid (HA). Furthermore, the presence of this glycosaminoglycan appears critical for the spatial distribution of transplanted stem cells in vivo. In addition, we also demonstrate that the binding of HA by a surrogate ligand results in marked inhibition of primitive hemopoietic cell proliferation and granulocyte differentiation. Collectively, these data describe an important yet previously unrecognized role for HA in the biology of primitive hemopoietic progenitor cells.

scholarly journals Studies on the effect of deoxyadenosine on deoxycoformycin-treated myeloid and lymphoid stem cells

Blood ◽  
1982 ◽  
Vol 60 (4) ◽  
pp. 872-876 ◽  
Author(s):  
MT Aye ◽  
JV Dunne ◽  
WC Yang
Keyword(s):  
Stem Cells ◽  
Adenosine Deaminase ◽  
Severe Combined Immunodeficiency ◽  
Immune Dysfunction ◽  
Model Systems ◽  
Hemopoietic Stem Cells ◽  
Combined Immunodeficiency ◽  
Proliferation And Differentiation ◽  
Immunodeficiency Disease ◽  
Severe Combined Immunodeficiency Disease

Abstract Adenosine deaminase (ADA) deficiency has been reported in association with severe combined immunodeficiency disease (SCID). The mechanism by which ADA deficiency causes immune dysfunction has been investigated in model systems to which the ADA inhibitor deoxycoformycin (dCf) had been added. Previously, we demonstrated that dCF did not prevent proliferation and differentiation of myeloid and lymphoid stem cells. We have now shown that addition of deoxyadenosine to dCf-containing cultures inhibited proliferation of hemopoietic stem cells. This inhibition was, however, equally effective for both normal myeloid and lymphoid stem cells. These findings suggest that other differences may exist between SCID myeloid and lymphoid stem cells to account for the relative sparing of myelopoiesis in SCID patients.

Sign in / Sign up

Export Citation Format

Share Document