scholarly journals Viral load assay performs comparably to early infant diagnosis assay to diagnose infants with HIV in Mozambique: a prospective observational study

2020 ◽  
Vol 23 (1) ◽  
Author(s):  
Adolfo Vubil ◽  
Carina Nhachigule ◽  
Osvaldo Loquiha ◽  
Bindiya Meggi ◽  
Nedio Mabunda ◽  
...  
Keyword(s):  
Viral Load ◽  
Observational Study ◽  
Prospective Observational Study ◽  
Early Infant Diagnosis ◽  
Early Infant ◽  
Viral Load Assay

Evaluation of a routine point-of-care intervention for early infant diagnosis of HIV: an observational study in eight African countries

2019 ◽  
Vol 6 (6) ◽  
pp. e373-e381 ◽  
Author(s):  
Flavia Bianchi ◽  
Jennifer Cohn ◽  
Emma Sacks ◽  
Rebecca Bailey ◽  
Jean-Francois Lemaire ◽  
...  
Keyword(s):  
Observational Study ◽  
Point Of Care ◽  
Early Infant Diagnosis ◽  
African Countries ◽  
Care Intervention ◽  
Early Infant

Reducing the viral load and early infant diagnosis results’ turnaround time in northwestern province, Zambia

2019 ◽  
Vol 493 ◽  
pp. S685
Author(s):  
A. Tembo ◽  
J. Banda ◽  
S. Musonda ◽  
I. Kabongu ◽  
H. Kassim ◽  
...  
Keyword(s):  
Viral Load ◽  
Turnaround Time ◽  
Early Infant Diagnosis ◽  
Early Infant

scholarly journals Early infant diagnosis HIV-1 PCR cycle-threshold predicts infant viral load at birth

2019 ◽  
Vol 114 ◽  
pp. 21-25 ◽  
Author(s):  
Ahmad Haeri Mazanderani ◽  
Tendesayi Kufa ◽  
Karl G. Technau ◽  
Renate Strehlau ◽  
Faeezah Patel ◽  
...  
Keyword(s):  
Viral Load ◽  
Early Infant Diagnosis ◽  
Cycle Threshold ◽  
Early Infant ◽  
Hiv 1

scholarly journals Point-of-Care Early Infant Diagnosis Improves Adherence to the Testing Algorithm in Kenya

2020 ◽  
Vol 19 ◽  
pp. 232595822090603
Author(s):  
Collins Otieno Odhiambo ◽  
George Githuka ◽  
Nancy Bowen ◽  
Leonard Kingwara ◽  
Jared Onsase ◽  
...  
Keyword(s):  
Viral Load ◽  
Point Of Care ◽  
Load Test ◽  
Baseline Viral Load ◽  
Early Infant Diagnosis ◽  
Confirmatory Testing ◽  
Subsequent Test ◽  
Early Infant ◽  
Viral Load Test ◽  
Testing Algorithm

Introduction: We determine the level of adherence to the revised Kenya early infant diagnosis (EID) algorithm during implementation of a point-of-care (POC) EID project. Methods: Data before (August 2016 to July 2017) and after (August 2017 to July 2018) introduction of POC EID were collected retrospectively from the national EID database and registers for 33 health facilities. We assessed the number of HIV-infected infants who underwent confirmatory testing and received baseline viral load test and proportion of infants with an initial negative result who had a subsequent test. Results and Discussion: Significantly higher number of infants accessed confirmatory testing (94.2% versus 38.6%; P < .0001) with POC EID. Baseline viral load test and follow-up testing at 6 months, although higher with POC EID, were not significantly different from the pre-POC EID intervention period. Conclusion: The POC EID implementation has the potential to increase proportion of infants who receive confirmatory testing, thus reducing the risk of false-positive results.

Results of Baseline Assessments of Two Viral Load and Early Infant Diagnosis Laboratories in Gaza Province, Mozambique

2019 ◽  
Vol 152 (Supplement_1) ◽  
pp. S79-S79
Author(s):  
Augusto Nhabomba ◽  
Mariamo Assane ◽  
Noorbebi Adamo ◽  
Octavia Benzane ◽  
Isabel Pinto ◽  
...  
Keyword(s):  
Viral Load ◽  
Scale Up ◽  
Hiv Prevalence ◽  
Internal Quality ◽  
Early Infant Diagnosis ◽  
Hiv Viral Load ◽  
Early Infant ◽  
Sample Management ◽  
Basic Infrastructure

Abstract Following the WHO 2013 recommendations for routine HIV viral load (VL) testing as the tool to monitor antiretroviral therapy, countries have prepared for massive testing scale-up. However, developing countries that also bear the highest HIV prevalence often lack qualified human resources and basic infrastructure. Mozambique has established 13 VL laboratories, including 2 in the province with the highest overall HIV prevalence, Gaza. The challenges to VL testing implementation and this rapid scale-up demand an urgent investment toward laboratory accreditation to ensure accurate and reliable VL results. To identify gaps and areas for improvement where additional resources may be needed to provide high-quality VL testing services, the CDC developed a VL and Early Infant Diagnosis (EID) scorecard (106 points; 5 levels). The scorecard evaluates 9 key areas, including (1) Personnel, (2) Facility/Environment, (3) Safety, (4) Procurement/Inventory, (5) Sample Management, (6) Equipment, (7) Process Control, (8) M&E Documents and Records, and (9) Internal Quality Audits/Quality Indicators. These 9 essential areas cover the pretesting, testing, and posttesting phases along the continuum of care for HIV patients. Baseline assessments in the two VL and EID laboratories in Gaza Province, Carmelo Molecular Laboratory and Xai-Xai Molecular Laboratory, were recently conducted. Personnel standards and M&E documentation represented strengths across both laboratories, with over 70% of the master list of M&E documents having been developed and in use. The overall gaps identified included poor segregation and prioritization of higher VL results (>1,000 cp/mL), lack of internal audits, and no follow-up of nonconformities. Both laboratories scored in the level 2 range, with a total of 68 points (Carmelo) and 78 points (Xai-Xai). Considering this is a baseline assessment, we conclude that both labs are on an excellent path toward accreditation; however, additional laboratory quality mentorship is needed in order to reach accreditation standards.

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