scholarly journals Point‐of‐care HIV maternal viral load and early infant diagnosis testing around time of delivery at tertiary obstetric units in South Africa: a prospective study of coverage, results return and turn‐around times

2020 ◽  
Vol 23 (4) ◽  
Author(s):  
Tendesayi Kufa ◽  
Ahmad H Mazanderani ◽  
Gayle G Sherman ◽  
Aurélie Mukendi ◽  
Tanya Murray ◽  
...  
Keyword(s):  
South Africa ◽  
Viral Load ◽  
Prospective Study ◽  
Point Of Care ◽  
Early Infant Diagnosis ◽  
Maternal Viral Load ◽  
Early Infant ◽  
A Prospective Study

scholarly journals Field evaluation of HIV point-of-care testing for early infant diagnosis in Cape Town, South Africa

PLoS ONE ◽  
2017 ◽  
Vol 12 (12) ◽  
pp. e0189226 ◽  
Author(s):  
Lorna Dunning ◽  
Max Kroon ◽  
Nei-yuan Hsiao ◽  
Landon Myer
Keyword(s):  
South Africa ◽  
Point Of Care ◽  
Cape Town ◽  
Field Evaluation ◽  
Early Infant Diagnosis ◽  
Point Of Care Testing ◽  
Early Infant

scholarly journals Point-of-Care Early Infant Diagnosis Improves Adherence to the Testing Algorithm in Kenya

2020 ◽  
Vol 19 ◽  
pp. 232595822090603
Author(s):  
Collins Otieno Odhiambo ◽  
George Githuka ◽  
Nancy Bowen ◽  
Leonard Kingwara ◽  
Jared Onsase ◽  
...  
Keyword(s):  
Viral Load ◽  
Point Of Care ◽  
Load Test ◽  
Baseline Viral Load ◽  
Early Infant Diagnosis ◽  
Confirmatory Testing ◽  
Subsequent Test ◽  
Early Infant ◽  
Viral Load Test ◽  
Testing Algorithm

Introduction: We determine the level of adherence to the revised Kenya early infant diagnosis (EID) algorithm during implementation of a point-of-care (POC) EID project. Methods: Data before (August 2016 to July 2017) and after (August 2017 to July 2018) introduction of POC EID were collected retrospectively from the national EID database and registers for 33 health facilities. We assessed the number of HIV-infected infants who underwent confirmatory testing and received baseline viral load test and proportion of infants with an initial negative result who had a subsequent test. Results and Discussion: Significantly higher number of infants accessed confirmatory testing (94.2% versus 38.6%; P < .0001) with POC EID. Baseline viral load test and follow-up testing at 6 months, although higher with POC EID, were not significantly different from the pre-POC EID intervention period. Conclusion: The POC EID implementation has the potential to increase proportion of infants who receive confirmatory testing, thus reducing the risk of false-positive results.

scholarly journals Impact of Birth HIV-PCR Testing on the Uptake of Follow-up Early Infant Diagnosis Services in Cape Town, South Africa

2017 ◽  
Vol 36 (12) ◽  
pp. 1159-1164 ◽  
Author(s):  
Lorna Dunning ◽  
Max Kroon ◽  
Lezanne Fourie ◽  
Andrea Ciaranello ◽  
Landon Myer
Keyword(s):  
South Africa ◽  
Cape Town ◽  
Early Infant Diagnosis ◽  
Early Infant

scholarly journals Assault-injured youth in the emergency centres of Khayelitsha, South Africa: A prospective study of recidivism and mortality

2021 ◽  
Vol 11 (4) ◽  
pp. 379-384
Author(s):  
Sarah C. Leeper ◽  
Mehul D. Patel ◽  
Sa'ad Lahri ◽  
Alexander Beja-Glasser ◽  
Priscilla Reddy ◽  
...  
Keyword(s):  
South Africa ◽  
Prospective Study ◽  
A Prospective Study

Hemoglobin screening in blood donors: a prospective study assessing the value of an invasive and a noninvasive point-of-care device for donor safety

Transfusion ◽  
2017 ◽  
Vol 57 (4) ◽  
pp. 938-945 ◽  
Author(s):  
Dorien De Clippel ◽  
Leen Van Heddegem ◽  
Giovani Vandewalle ◽  
Philippe Vandekerckhove ◽  
Veerle Compernolle
Keyword(s):  
Prospective Study ◽  
Blood Donors ◽  
Point Of Care ◽  
Donor Safety ◽  
A Prospective Study

scholarly journals Feasibility and acceptability of implementing early infant diagnosis of HIV in Papua New Guinea at the point of care: a qualitative exploration of health worker and key informant perspectives

BMJ Open ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. e043679
Author(s):  
Yasmin Mohamed ◽  
Martha Kupul ◽  
Janet Gare ◽  
Steven G Badman ◽  
Selina Silim ◽  
...  
Keyword(s):  
Papua New Guinea ◽  
Standard Care ◽  
Health Workers ◽  
Point Of Care ◽  
Hiv Positive ◽  
Early Infant Diagnosis ◽  
Pmtct Programme ◽  
Early Infant ◽  
Qualitative Exploration ◽  
Hiv 1

IntroductionEarly infant diagnosis (EID) of HIV and timely initiation of antiretroviral therapy can significantly reduce morbidity and mortality among HIV-positive infants. Access to EID is limited in many low-income and middle-income settings, particularly those in which standard care involves dried blood spots (DBS) sent to centralised laboratories, such as in Papua New Guinea (PNG). We conducted a qualitative exploration of the feasibility and acceptability of implementing a point-of-care (POC) EID test (Xpert HIV-1 Qualitative assay) among health workers and key stakeholders working within the prevention of mother-to-child transmission of HIV (PMTCT) programme in PNG.MethodsThis qualitative substudy was conducted as part of a pragmatic trial to investigate the effectiveness of the Xpert HIV-1 Qualitative test for EID in PNG and Myanmar. Semistructured interviews were undertaken with 5 health workers and 13 key informants to explore current services, experiences of EID testing, perspectives on the Xpert test and the feasibility of integrating and scaling up POC EID in PNG. Coding was undertaken using inductive and deductive approaches, drawing on existing acceptability and feasibility frameworks.ResultsHealth workers and key informants (N=18) felt EID at POC was feasible to implement and beneficial to HIV-exposed infants and their families, staff and the PMTCT programme more broadly. All study participants highlighted starting HIV-positive infants on treatment immediately as the main advantage of POC EID compared with standard care DBS testing. Health workers identified insufficient resources to follow up infants and caregivers and space constraints in hospitals as barriers to implementation. Participants emphasised the importance of adequate human resources, ongoing training and support, appropriate coordination and a sustainable supply of consumables to ensure effective scale-up of the test throughout PNG.ConclusionsImplementation of POC EID in a low HIV prevalence setting such as PNG is likely to be both feasible and beneficial with careful planning and adequate resources.Trial registration number12616000734460.

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