scholarly journals Selecting a viral load threshold for routine monitoring in resource-limited settings: optimizing individual health and population impact

2017 ◽  
Vol 20 ◽  
pp. e25007 ◽  
Author(s):  
Tanya M Ellman ◽  
Bereket Alemayehu ◽  
Elaine J Abrams ◽  
Stephen Arpadi ◽  
Andrea A Howard ◽  
...  
Keyword(s):  
Viral Load ◽  
Resource Limited Settings ◽  
Population Impact ◽  
Individual Health ◽  
Resource Limited ◽  
Routine Monitoring

Evaluation of two commercially available alternatives for HIV-1 viral load testing in resource-limited settings

2007 ◽  
Vol 146 (1-2) ◽  
pp. 178-187 ◽  
Author(s):  
Kim Steegen ◽  
Stanley Luchters ◽  
Nancy De Cabooter ◽  
Jacqueline Reynaerts ◽  
Kishor Mandaliya ◽  
...  
Keyword(s):  
Viral Load ◽  
Load Testing ◽  
Resource Limited Settings ◽  
Viral Load Testing ◽  
Resource Limited ◽  
Hiv 1

Viral load monitoring in resource-limited settings

AIDS ◽  
2012 ◽  
Vol 26 (13) ◽  
pp. 1719-1720 ◽  
Author(s):  
Nathan Ford ◽  
Teri Roberts ◽  
Alexandra Calmy
Keyword(s):  
Viral Load ◽  
Resource Limited Settings ◽  
Resource Limited ◽  
Viral Load Monitoring ◽  
Load Monitoring

scholarly journals HIV-1 Viral Load Assays for Resource-Limited Settings: Clades Matter

PLoS Medicine ◽  
2006 ◽  
Vol 3 (12) ◽  
pp. e538 ◽  
Author(s):  
Wolfgang Preiser ◽  
Jan Felix Drexler ◽  
Christian Drosten
Keyword(s):  
Viral Load ◽  
Resource Limited Settings ◽  
Resource Limited ◽  
Hiv 1

scholarly journals Use of Dried Plasma Spots for HIV-1 Viral Load Determination and Drug Resistance Genotyping in Mexican Patients

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Juan Pablo Rodriguez-Auad ◽  
Othon Rojas-Montes ◽  
Angelica Maldonado-Rodriguez ◽  
Ma. Teresa Alvarez-Muñoz ◽  
Onofre Muñoz ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Viral Load ◽  
Attractive Alternative ◽  
Plasma Samples ◽  
Resistance Mutations ◽  
Resource Limited Settings ◽  
Middle Income ◽  
Subtype B ◽  
Resource Limited ◽  
Hiv 1

Monitoring antiretroviral therapy using measurements of viral load (VL) and the genotyping of resistance mutations is not routinely performed in low- to middle-income countries because of the high costs of the commercial assays that are used. The analysis of dried plasma spot (DPS) samples on filter paper may represent an alternative for resource-limited settings. Therefore, we evaluated the usefulness of analyzing DPS samples to determine VL and identify drug resistance mutations (DRM) in a group of HIV-1 patients. The VL was measured from 22 paired plasma and DPS samples. In these samples, the average VL was 4.7 log10copies/mL in liquid plasma and 4.1 log10copies/mL in DPS, with a correlation coefficient ofR= 0.83. A 1.1 kb fragment of HIVpolcould be amplified in 14/22 (63.6%) of the DPS samples and the same value was amplified in plasma samples. A collection of ten paired DPS and liquid plasma samples was evaluated for the presence of DRM; an excellent correlation was found in the identification of DRM between the paired samples. All HIV-1polsequences that were obtained corresponded to HIV subtype B. The analysis of DPS samples offers an attractive alternative for monitoring ARV therapy in resource-limited settings.

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