Tetraethylene Glycol Tethered Heteronuclear Bis-isatin Derivatives: Design, Synthesis, and In Vitro Anti-mycobacterial Activities

2018 ◽  
Vol 55 (9) ◽  
pp. 2172-2177 ◽  
Author(s):  
Shuang-Qi Zhao ◽  
Yan Xu ◽  
Jianguo Guan ◽  
Shijia Zhao ◽  
Guang-De Zhang ◽  
...  
Keyword(s):  
Tetraethylene Glycol ◽  
Design Synthesis ◽  
Isatin Derivatives

Design, Synthesis, and In Vitro Anti‐mycobacterial Activities of 1,2,3‐Triazole‐tetraethylene Glycol Tethered Isatin Dimers

2018 ◽  
Vol 55 (12) ◽  
pp. 3006-3010 ◽  
Author(s):  
Shi‐Jia Zhao ◽  
Zao‐Sheng Lv ◽  
Jia‐Lun Deng ◽  
Feng Gao ◽  
Guang‐De Zhang ◽  
...  
Keyword(s):  
Tetraethylene Glycol ◽  
Design Synthesis

Design, synthesis and in vitro anti-mycobacterial activities of homonuclear and heteronuclear bis-isatin derivatives

Fitoterapia ◽  
2018 ◽  
Vol 127 ◽  
pp. 383-386 ◽  
Author(s):  
Yan Xu ◽  
Jianguo Guan ◽  
Zhi Xu ◽  
Shijia Zhao
Keyword(s):  
Design Synthesis ◽  
Isatin Derivatives

Design, synthesis and in vitro cytotoxicity evaluation of 5-(2-carboxyethenyl)isatin derivatives as anticancer agents

2014 ◽  
Vol 24 (2) ◽  
pp. 591-594 ◽  
Author(s):  
Kailin Han ◽  
Yao Zhou ◽  
Fengxi Liu ◽  
Qiannan Guo ◽  
Pengfei Wang ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
In Vitro Cytotoxicity ◽  
Design Synthesis ◽  
Isatin Derivatives

Design, Synthesis, and In Vitro Anti‐Mycobacterial Activities of Tetraethylene Glycol Tethered Isatin Dimers

2018 ◽  
Vol 55 (12) ◽  
pp. 2985-2989 ◽  
Author(s):  
Shi‐Jia Zhao ◽  
Zao‐Sheng Lv ◽  
Lin Shi ◽  
Shuang‐Qi Zhao ◽  
Zhi Xu
Keyword(s):  
Tetraethylene Glycol ◽  
Design Synthesis

scholarly journals Design, Synthesis, Antimicrobial and Anticancer Activity of some Novel Benzoxazole-Isatin Conjugates

2021 ◽  
Vol 12 (2) ◽  
pp. 2392-2403
Keyword(s):  
Antibacterial Activity ◽  
Human Cancer ◽  
Cytotoxic Activities ◽  
Human Cancer Cell ◽  
Design Synthesis ◽  
Protein Targets ◽  
Human Cancer Cell Lines ◽  
Fungal Organisms ◽  
Isatin Derivatives

A series of novel benzoxazole-isatin conjugates were synthesized by treating 2-amino benzoxazole with 5 and 7 substituted isatin derivatives and were screened for in vitro antimicrobial and cytotoxic activities. The results showed that all the synthesized compounds shown mild to potent antibacterial activity. The MIC values were found between 10 and 100 µg/ml against tested bacterial and fungal organisms. Among all the compounds, 3d & 3c showed good antimicrobial. In vitro cytotoxic activities were evaluated by MTT assay of all the test compounds against the different human cancer cell lines. The compounds having substitution with electron-withdrawing groups (halides) at the 5th position on the isatin ring showed the most significant biological activity than substituted at the 7th position. The molecular docking interactions have shown good binding interactions with the protein targets glucosamine-6-phosphate synthase (GlcN-6-P synthase) and telomerase.

Design, synthesis and anti-plasmodial evaluation in vitro of new 4-aminoquinoline isatin derivatives

2005 ◽  
Vol 13 (9) ◽  
pp. 3249-3261 ◽  
Author(s):  
Idan Chiyanzu ◽  
Cailean Clarkson ◽  
Peter J. Smith ◽  
Julie Lehman ◽  
Jiri Gut ◽  
...  
Keyword(s):  
Design Synthesis ◽  
Isatin Derivatives
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