Design, Synthesis, and In Vitro Anti‐Tumor Activities of 1,2,3‐triazole‐tetraethylene Glycol Tethered Heteronuclear Bis‐Schiff Base Derivatives of Isatin

2018 ◽  
Vol 55 (12) ◽  
pp. 3001-3005 ◽  
Author(s):  
Ruo Wang ◽  
Xueyang Yin ◽  
Yaohuan Zhang ◽  
Tesen Zhang ◽  
Weixiong Shi
Keyword(s):  
Schiff Base ◽  
Tetraethylene Glycol ◽  
Design Synthesis ◽  
Schiff Base Derivatives ◽  
Derivatives Of

Synthesis, in vitro and in vivo antitumor activity of symmetrical bis-Schiff base derivatives of isatin

2014 ◽  
Vol 74 ◽  
pp. 742-750 ◽  
Author(s):  
Chengyuan Liang ◽  
Juan Xia ◽  
Dong Lei ◽  
Xiang Li ◽  
Qizheng Yao ◽  
...  
Keyword(s):  
Schiff Base ◽  
Antitumor Activity ◽  
Schiff Base Derivatives ◽  
In Vivo Antitumor Activity ◽  
Derivatives Of

scholarly journals Characterization of Antimicrobial, Antioxidant, and Leishmanicidal Activities of Schiff Base Derivatives of 4-Aminoantipyrine

Molecules ◽  
2019 ◽  
Vol 24 (15) ◽  
pp. 2696 ◽  
Author(s):  
Teran ◽  
Guevara ◽  
Mora ◽  
Dobronski ◽  
Barreiro-Costa ◽  
...  
Keyword(s):  
Schiff Base ◽  
Schiff Bases ◽  
Antimicrobial Activities ◽  
Drug Candidates ◽  
Development Of Resistance ◽  
Schiff Base Derivatives ◽  
Wide Range ◽  
Derivatives Of

Our main interest is the characterization of compounds to support the development of alternatives to currently marketed drugs that are losing effectiveness due to the development of resistance. Schiff bases are promising biologically interesting compounds having a wide range of pharmaceutical properties, including anti-inflammatory, antipyretic, and antimicrobial activities, among others. In this work, we have synthesized 12 Schiff base derivatives of 4-aminoantipyrine. In vitro antimicrobial, antioxidant, and cytotoxicity properties are analyzed, as well as in silico predictive adsorption, distribution, metabolism, and excretion (ADME) and bioactivity scores. Results identify two potential Schiff bases: one effective against E. faecalis and the other with antioxidant activity. Both have reasonable ADME scores and provides a scaffold for developing more effective compounds in the future. Initial studies are usually limited to laboratory in vitro approaches, and following these initial studies, much research is needed before a drug can reach the clinic. Nevertheless, these laboratory approaches are mandatory and constitute a first filter to discriminate among potential drug candidates and chemical compounds that should be discarded.

Design, Synthesis, and In Vitro Anti‐mycobacterial Activities of 1,2,3‐Triazole‐tetraethylene Glycol Tethered Isatin Dimers

2018 ◽  
Vol 55 (12) ◽  
pp. 3006-3010 ◽  
Author(s):  
Shi‐Jia Zhao ◽  
Zao‐Sheng Lv ◽  
Jia‐Lun Deng ◽  
Feng Gao ◽  
Guang‐De Zhang ◽  
...  
Keyword(s):  
Tetraethylene Glycol ◽  
Design Synthesis

New Helical Zinc Complexes with Schiff Base Derivatives of β-Diketonates or β-Keto Esters and Ethylenediamine

2009 ◽  
Vol 2009 (23) ◽  
pp. 3467-3474 ◽  
Author(s):  
Oxana Kotova ◽  
Sergey Semenov ◽  
Svetlana Eliseeva ◽  
Sergey Troyanov ◽  
Konstantin Lyssenko ◽  
...  
Keyword(s):  
Schiff Base ◽  
Zinc Complexes ◽  
Keto Esters ◽  
Schiff Base Derivatives ◽  
Derivatives Of
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