Recent Advances in Imidazo[5,1-f ][1,2,4]triazin-4(3H )-ones Chemistry: An Overview of the Synthetic Routes to Vardenafil and Its Analogues

2018 ◽  
Vol 55 (3) ◽  
pp. 564-585 ◽  
Author(s):  
Moustafa A. Gouda
Keyword(s):  
Recent Advances ◽  
Synthetic Routes

Recent advances and new concepts for the synthesis of axially stereoenriched biaryls

2015 ◽  
Vol 44 (11) ◽  
pp. 3418-3430 ◽  
Author(s):  
J. Wencel-Delord ◽  
A. Panossian ◽  
F. R. Leroux ◽  
F. Colobert
Keyword(s):  
Chiral Compounds ◽  
The Past ◽  
Recent Advances ◽  
New Concepts ◽  
Axially Chiral ◽  
Recent Developments ◽  
Synthetic Routes

Over the past decade the field of the synthesis of axially chiral compounds has been rapidly expanding. Not only key advances have been achieved concerning the already established strategies but also new synthetic routes have been devised. This review showcases the recent developments in this domain.

scholarly journals Recent advances in carbon nanospheres: synthetic routes and applications

2015 ◽  
Vol 51 (45) ◽  
pp. 9246-9256 ◽  
Author(s):  
Pengfei Zhang ◽  
Zhen-An Qiao ◽  
Sheng Dai
Keyword(s):  
Carbon Nanospheres ◽  
Feature Article ◽  
Recent Advances ◽  
Synthetic Routes

Various strategies to carbon nanospheres together with a brief introduction of applications are presented in this feature article.

Recent advances in the synthesis and reactivity of quinoxaline

2021 ◽  
Author(s):  
Gauravi Yashwantrao ◽  
Satyajit Saha
Keyword(s):  
Bioactive Molecules ◽  
Sensing Applications ◽  
Recent Advances ◽  
Synthetic Routes

Quinoxalines are observed in several bioactive molecules and have been widely employed in designing molecules for DSSC's, optoelectronics, and sensing applications. Therefore, developing newer synthetic routes as well as novel ways for their functionalization is apparent.

scholarly journals Recent Advances in the Synthesis of Ibuprofen and Naproxen

Molecules ◽  
2021 ◽  
Vol 26 (16) ◽  
pp. 4792
Author(s):  
Min-Woo Ha ◽  
Seung-Mann Paek
Keyword(s):  
Continuous Flow ◽  
Recent Progress ◽  
Flow Chemistry ◽  
Synthetic Route ◽  
Recent Advances ◽  
Continuous Flow Chemistry ◽  
Inflammatory Drugs ◽  
Synthetic Routes ◽  
Anti Inflammatory

Herein, we review the recent progress in the synthesis of representative nonsteroidal anti-inflammatory drugs (NSAIDs), ibuprofen and naproxen. Although these drugs were discovered over 50 years ago, novel practical and asymmetric approaches are still being developed for their synthesis. In addition, this endeavor has enabled access to more potent and selective derivatives from the key frameworks of ibuprofen and naproxen. The development of a synthetic route to ibuprofen and naproxen over the last 10 years is summarized, including developing methodologies, finding novel synthetic routes, and applying continuous-flow chemistry.

O2-Mediated Photocatalytic Functionalization of Organic Compounds: Recent Advances Towards Greener Synthetic Routes

2013 ◽  
Vol 17 (21) ◽  
pp. 2406-2419 ◽  
Author(s):  
Cristian Gambarotti ◽  
Lucio Melone ◽  
Tullio Caronna ◽  
Carlo Punta
Keyword(s):  
Organic Compounds ◽  
Recent Advances ◽  
Synthetic Routes

ChemInform Abstract: Recent Advances in Carbon Nanospheres: Synthetic Routes and Applications

ChemInform ◽  
2015 ◽  
Vol 46 (30) ◽  
pp. no-no
Author(s):  
Pengfei Zhang ◽  
Zhen-An Qiao ◽  
Sheng Dai
Keyword(s):  
Carbon Nanospheres ◽  
Recent Advances ◽  
Synthetic Routes

Recent advances in synthesis and reactions of β-amino-α,β-enones (enaminones)

2021 ◽  
Vol 18 ◽  
Author(s):  
Thoraya Farghaly ◽  
Alaa M. Abo Alnaja ◽  
Mohamed R. Shaaban
Keyword(s):  
Carbonyl Compounds ◽  
Heterocyclic Compounds ◽  
Heterocyclic Ring ◽  
Ring Systems ◽  
Organic Syntheses ◽  
Recent Advances ◽  
Synthetic Routes

Abstract: β-Amino-α,β-enones or β-enamino carbonyl compounds are versatile synthons intermediates for the construction of various bio-active heterocyclic compounds and have been established as multipurpose synthetic precursors in organic syntheses and in pharmaceutical developments. In this work, we will discuss the different synthetic routes to obtain β-Amino-α,β-enones or β-enamino carbonyl compounds, their reactions, and their utility in the construction of organic frameworks and heterocyclic ring systems. Structurally, β-amino-α,β-enones are attractive intermediates that syndicate the ambident behaviours of nucleophilicity and electrophilicity of enones simultaneously. β-amino-α,β-enones have been known as acceptors in both 1,2- and 1,4- additions, which make them good intermediate compounds for annulation to different heterocycles.

A Review of Cationic Arylfurans and Their Isosteres: Synthesis and Biological Importance

2020 ◽  
Vol 23 (24) ◽  
pp. 2751-2782 ◽  
Author(s):  
Mohamed A. Ismail ◽  
Wael M. El-Sayed ◽  
Saad Shaaban ◽  
Ghada A. Abdelwahab ◽  
Wafaa S. Hamama
Keyword(s):  
Biological Activities ◽  
Structure Optimization ◽  
Literature Survey ◽  
Synthetic Methods ◽  
Biological Importance ◽  
Recent Advances ◽  
The Future ◽  
Synthetic Routes

The present study provides an overview of the chemistry and biological importance of the cationic chalcophene derivatives (furans, thiophenes and selenophenes). The summarized literature survey includes synthetic methods, reactivity and biological activities of aryl/hetarylchalcophenes that have been reported mainly from 2001 to 2019 focusing on monochalcophenes. A discussion demonstrating the proposed mechanisms of some interesting synthetic routes and linking structure features to biological activities is presented. These classes of compounds including cationic chalcophenes possess antiproliferative, antimicrobial and antiprotozoal activities. This review highlights recent advances for arylchalcophene derivatives and may contribute to the design and structure optimization of new chalcophene derivatives in the future.

scholarly journals Leloir Glycosyltransferases in Applied Biocatalysis: A Multidisciplinary Approach

2019 ◽  
Vol 20 (21) ◽  
pp. 5263 ◽  
Author(s):  
Mestrom ◽  
Przypis ◽  
Kowalczykiewicz ◽  
Pollender ◽  
Kumpf ◽  
...  
Keyword(s):  
Multidisciplinary Approach ◽  
Efficient Production ◽  
Nucleotide Sugar ◽  
One Pot ◽  
Recent Advances ◽  
Excellent Control ◽  
Efficient Coupling ◽  
Synthetic Routes ◽  
The Way

Enzymes are nature’s catalyst of choice for the highly selective and efficient coupling of carbohydrates. Enzymatic sugar coupling is a competitive technology for industrial glycosylation reactions, since chemical synthetic routes require extensive use of laborious protection group manipulations and often lack regio- and stereoselectivity. The application of Leloir glycosyltransferases has received considerable attention in recent years and offers excellent control over the reactivity and selectivity of glycosylation reactions with unprotected carbohydrates, paving the way for previously inaccessible synthetic routes. The development of nucleotide recycling cascades has allowed for the efficient production and reuse of nucleotide sugar donors in robust one-pot multi-enzyme glycosylation cascades. In this way, large glycans and glycoconjugates with complex stereochemistry can be constructed. With recent advances, LeLoir glycosyltransferases are close to being applied industrially in multi-enzyme, programmable cascade glycosylations.

Recent Advances in High Dispersion Spectroscopy of Globular Cluster Stars

1988 ◽  
Vol 132 ◽  
pp. 525-530
Author(s):  
Raffaele G. Gratton
Keyword(s):  
Globular Cluster ◽  
Globular Clusters ◽  
High Dispersion ◽  
Photographic Material ◽  
Recent Advances ◽  
Metal Abundances ◽  
Ccd Detectors ◽  
Major Progress

The use CCD detectors has allowed a major progress in abundance derivations for globular cluster stars in the last years. Abundances deduced from high dispersion spectra now correlates well with other abundance indicators. I discuss some problems concerning the derivation of accurate metal abundances for globular clusters using high dispersion spectra from both the old photographic and the most recent CCD data. The discrepant low abundances found by Cohen (1980), from photographic material for M71 giants, are found to be due to the use of too high microturbulences.

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