Synthesis of Quinoline Derivatives by Multicomponent Reaction Using Niobium Pentachloride as Lewis Acid

2014 ◽  
Vol 52 (1) ◽  
pp. 273-277 ◽  
Author(s):  
Aloisio de Andrade ◽  
Giovanny Carvalho dos Santos ◽  
Luiz Carlos da Silva-Filho
Keyword(s):  
Lewis Acid ◽  
Multicomponent Reaction ◽  
Quinoline Derivatives ◽  
Niobium Pentachloride

ChemInform Abstract: Synthesis of Quinoline Derivatives by Multicomponent Reaction Using Niobium Pentachloride as Lewis Acid.

ChemInform ◽  
2015 ◽  
Vol 46 (24) ◽  
pp. no-no
Author(s):  
Aloisio de Andrade ◽  
Giovanny Carvalho dos Santos ◽  
Luiz Carlos da Silva-Filho
Keyword(s):  
Lewis Acid ◽  
Multicomponent Reaction ◽  
Quinoline Derivatives ◽  
Niobium Pentachloride

A heavy metal- and oxidant-free, one-pot synthesis of pyridines and fused pyridines based on a Lewis acid-catalyzed multicomponent reaction

2014 ◽  
Vol 50 (82) ◽  
pp. 12270-12272 ◽  
Author(s):  
V. P. Alex Raja ◽  
Giammarco Tenti ◽  
Subbu Perumal ◽  
J. Carlos Menéndez
Keyword(s):  
Heavy Metal ◽  
Lewis Acid ◽  
Multicomponent Reaction ◽  
One Pot ◽  
One Pot Synthesis ◽  
Acid Catalyzed

Pyridines and fused pyridines are accessible by a combination of a Lewis acid-catalyzed multicomponent reaction and aromatization involving loss of a 2-furylmethyl chain.

Synthesis of 4,5-Diaminopyrrolo[1,2-a]quinoline Derivatives by a Lewis Acid Catalyzed Reaction of 2-(Pyrrol-1-yl)benzaldimines with Isocyanides

Heterocycles ◽  
2007 ◽  
Vol 71 (3) ◽  
pp. 691 ◽  
Author(s):  
Kazuhiro Kobayashi ◽  
Yasutoshi Himei ◽  
Yuichi Izumi ◽  
Shuhei Fukamachi ◽  
Osamu Morikawa ◽  
...  
Keyword(s):  
Lewis Acid ◽  
Quinoline Derivatives ◽  
Acid Catalyzed

One-Step Synthesis of Methoxylated Phloroglucinol Derivatives Promoted by Niobium Pentachloride: An Experimental and Theoretical Approach

Synthesis ◽  
2017 ◽  
Vol 49 (11) ◽  
pp. 2402-2410 ◽  
Author(s):  
Willian dos Santos ◽  
Eliezer de Oliveira ◽  
Francisco Lavarda ◽  
Ives Leonarczyk ◽  
Marco Ferreira ◽  
...  
Keyword(s):  
Multicomponent Reaction ◽  
Density Functional ◽  
Reaction Times ◽  
Cost Effective ◽  
Reactive Intermediates ◽  
Important Class ◽  
Functional Theory ◽  
Niobium Pentachloride ◽  
Phloroglucinol Derivatives ◽  
One Step

Phloroglucinol derivatives are an important class of natural compounds featuring the rhodomyrtone derivatives. In this work, the synthesis of compounds with a structure core of rhodomyrtosone I is described using a multicomponent reaction between aldehyde derivatives, dihydroresorcinol, and 3,5-dimethoxyphenol promoted by niobium pentachloride. This new method is simple, cost-effective, and provides a good yield. In addition, it can be conducted in good reaction times. Using Density Functional Theory (DFT) studies, bases are provided for a proposed reaction mechanism for the multicomponent reaction by exploring the energetics of proposed reactive intermediates and transition states.

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