A New Multicomponent Reaction Catalyzed by a [Lewis Acid]+[Co(CO)4]-Catalyst:  Stereospecific Synthesis of 1,3-Oxazinane-2,4-diones from Epoxides, Isocyanates, and CO

2007 ◽  
Vol 129 (26) ◽  
pp. 8156-8162 ◽  
Author(s):  
Tamara L. Church ◽  
Christopher M. Byrne ◽  
Emil B. Lobkovsky ◽  
Geoffrey W. Coates
Keyword(s):  
Lewis Acid ◽  
Multicomponent Reaction ◽  
Stereospecific Synthesis

A heavy metal- and oxidant-free, one-pot synthesis of pyridines and fused pyridines based on a Lewis acid-catalyzed multicomponent reaction

2014 ◽  
Vol 50 (82) ◽  
pp. 12270-12272 ◽  
Author(s):  
V. P. Alex Raja ◽  
Giammarco Tenti ◽  
Subbu Perumal ◽  
J. Carlos Menéndez
Keyword(s):  
Heavy Metal ◽  
Lewis Acid ◽  
Multicomponent Reaction ◽  
One Pot ◽  
One Pot Synthesis ◽  
Acid Catalyzed

Pyridines and fused pyridines are accessible by a combination of a Lewis acid-catalyzed multicomponent reaction and aromatization involving loss of a 2-furylmethyl chain.

Synthesis of exo- and endo-brevicomin and frontalin

1979 ◽  
Vol 57 (12) ◽  
pp. 1475-1480 ◽  
Author(s):  
Phaik-Eng Sum ◽  
Larry Weiler
Keyword(s):  
Lewis Acid ◽  
Stereospecific Synthesis ◽  
Methyl Acetoacetate ◽  
Natural Pheromone

The dianion of methyl acetoacetate is alkylated at the γ-carbon with homoallylic bromides. The resulting alkenes are epoxidized and then cyclized with a Lewis acid to produce esters of 6,8-dioxabicyclo[3.2.1]octane. These esters can be hydrolyzed and decarboxylated in a novel reaction. This methodology has been applied to a stereospecific synthesis of the title compounds. In addition, one of the intermediates in the exo-brevicomin synthesis can be resolved to provide the natural (+)-pheromone.

ChemInform Abstract: Synthesis of Quinoline Derivatives by Multicomponent Reaction Using Niobium Pentachloride as Lewis Acid.

ChemInform ◽  
2015 ◽  
Vol 46 (24) ◽  
pp. no-no
Author(s):  
Aloisio de Andrade ◽  
Giovanny Carvalho dos Santos ◽  
Luiz Carlos da Silva-Filho
Keyword(s):  
Lewis Acid ◽  
Multicomponent Reaction ◽  
Quinoline Derivatives ◽  
Niobium Pentachloride
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