A “One Pot,” Environmentally Friendly, Multicomponent Synthesis of 2-Amino-5-cyano-4-[(2-aryl)-1H-indol-3-yl]-6-hydroxypyrimidines and Their Antimicrobial Activity

2014 ◽  
Vol 51 (5) ◽  
pp. 1395-1403 ◽  
Author(s):  
Ragini Gupta ◽  
Anshu Jain ◽  
Yogita Madan ◽  
Ekta Menghani
Keyword(s):  
Antimicrobial Activity ◽  
Environmentally Friendly ◽  
Multicomponent Synthesis ◽  
One Pot

A regioselective one-pot aza-Friedel–Crafts reaction for primary, secondary and tertiary anilines using a heterogeneous catalyst

2017 ◽  
Vol 19 (23) ◽  
pp. 5683-5690 ◽  
Author(s):  
Giovanna Bosica ◽  
Roderick Abdilla
Keyword(s):  
Heterogeneous Catalyst ◽  
Environmentally Friendly ◽  
Silicotungstic Acid ◽  
Multicomponent Synthesis ◽  
One Pot ◽  
Amberlyst 15

An environmentally friendly one-pot multicomponent synthesis of 3-substituted indoles, catalysed by silicotungstic acid on Amberlyst 15 under green, neat conditions.

scholarly journals Metal-free Catalyzed One-Pot Multicomponent Synthesis of (E)-3-(2-((5-(Benzylideneamino)-1,3,4-thiadiazol-2-yl)thio) Acetyl)-2H-chromen-2-one Derivatives and Their Biological Evaluation

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Shivanand Merugu ◽  
Vijaya Kumar Ponnamaneni ◽  
Ravi Varala ◽  
Syed Farooq Adil ◽  
Mujeeb Khan ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Spectral Data ◽  
Multicomponent Reaction ◽  
Biological Evaluation ◽  
Anhydrous Ethanol ◽  
Multicomponent Synthesis ◽  
One Pot ◽  
Metal Free ◽  
Substituted Benzaldehydes

A series of (E)-3-(2-((5-(benzylideneamino)-1,3,4-thiadiazol-2-yl)thio) acetyl)-2H-chromen-2-one and its derivatives (4a-h) have been obtained using a one-pot multicomponent reaction with good yields. The compounds have been synthesized from 3-(2-bromoacetyl)chromen-2-ones (1), 5-amino-1,3,4-thiadiazole-2-thiol (2), and substituted benzaldehydes (3) in anhydrous ethanol and conc. H2SO4. Subsequently, all the synthesized compounds have been screened for their antimicrobial activity and characterized by analytical and spectral data.

One-pot multicomponent synthesis of novel thiazolylhydrazone derivatives and their antimicrobial activity

2015 ◽  
Vol 41 (12) ◽  
pp. 9703-9713 ◽  
Author(s):  
G. Rajitha ◽  
V. Ravibabu ◽  
G. Ramesh ◽  
B. Rajitha ◽  
R. Jobina ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Multicomponent Synthesis ◽  
One Pot

Copper-catalyzed Convenient Synthesis and SAR Studies of Substituted-1,2,3-triazole as Antimicrobial Agents

2018 ◽  
Vol 16 (1) ◽  
pp. 3-10
Author(s):  
Aniket P. Sarkate ◽  
Kshipra S. Karnik ◽  
Pravin S. Wakte ◽  
Ajinkya P. Sarkate ◽  
Ashwini V. Izankar ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Antifungal Activity ◽  
Antimicrobial Agents ◽  
Cycloaddition Reaction ◽  
Dipolar Cycloaddition ◽  
One Pot ◽  
Triazole Derivatives ◽  
Sar Studies ◽  
Convenient Synthesis ◽  
Antibacterial And Antifungal

Background:A novel copper-catalyzed synthesis of substituted-1,2,3-triazole derivatives has been developed and performed by Huisgen 1,3-dipolar cycloaddition reaction of azides with alkynes. The reaction is one-pot multicomponent.Objective:We state the advancement and execution of a methodology allowing for the synthesis of some new substituted 1,2,3-triazole analogues with antimicrobial activity.Methods:A series of triazole derivatives was synthesized by Huisgen 1,3-dipolar cycloaddition reaction of azides with alkynes. The structures of the synthesized compounds were elucidated and confirmed by 1H NMR, IR, MS and elemental analysis. All the synthesized compounds were tested for their antimicrobial activity against a series of strains of Bacillus subtilis, Staphylococcus aureus and Escherichia coli for antibacterial activity and against the strains of Candida albicans, Aspergillus flavus and Aspergillus nigar for antifungal activity, respectively.Results and Conclusion:From the antimicrobial data, it was observed that all the newly synthesized compounds showed good to moderate level of antibacterial and antifungal activity.

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