Antisense oligodeoxynucleotide against HST-1/FGF-4 suppresses tumorigenicity of an orthotopic model for human germ cell tumor in nude mice

2003 ◽  
Vol 5 (11) ◽  
pp. 951-957 ◽  
Author(s):  
Kotaro Hirai ◽  
Hideo Sasaki ◽  
Hiromi Sakamoto ◽  
Fumitaka Takeshita ◽  
Koji Asano ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Nude Mice ◽  
Cell Tumor ◽  
Antisense Oligodeoxynucleotide ◽  
Orthotopic Model ◽  
Human Germ Cell Tumor

scholarly journals Differentiation of human germ cell tumor cells in vivo and in vitro.

1992 ◽  
Vol 25 (5) ◽  
pp. 563-576 ◽  
Author(s):  
JUN-ICHI HATA ◽  
JUNICHIRO FUJIMOTO ◽  
EIZABURO ISHII ◽  
AKIHIRO UMEZAWA ◽  
YASUO KOKAI ◽  
...  
Keyword(s):  
Germ Cell ◽  
Tumor Cells ◽  
Germ Cell Tumor ◽  
Cell Tumor ◽  
Human Germ Cell Tumor

Human Germ Cell Tumor Cell Lines Express Novel Leukemia Inhibitory Factor Transcripts Encoding Differentially Localized Proteins

1999 ◽  
Vol 249 (2) ◽  
pp. 199-211 ◽  
Author(s):  
Roger B. Voyle ◽  
Bryan P. Haines ◽  
Martin F. Pera ◽  
Regan Forrest ◽  
Peter D. Rathjen
Keyword(s):  
Tumor Cell ◽  
Germ Cell ◽  
Cell Lines ◽  
Germ Cell Tumor ◽  
Leukemia Inhibitory Factor ◽  
Cell Tumor ◽  
Inhibitory Factor ◽  
Tumor Cell Lines ◽  
Human Germ Cell Tumor

A cloned human germ cell tumor-derived cell line differentiating in culture

1998 ◽  
Vol 77 (5) ◽  
pp. 710-719 ◽  
Author(s):  
Jukka Tienari ◽  
Ilkka Reima ◽  
Marcelo L. Larramendy ◽  
Sakari Knuutila ◽  
Kristina von Boguslawsky ◽  
...  
Keyword(s):  
Germ Cell ◽  
Cell Line ◽  
Germ Cell Tumor ◽  
Cell Tumor ◽  
Human Germ Cell Tumor

scholarly journals Human Endogenous Retrovirus Family HERV-K(HML-2) RNA Transcripts Are Selectively Packaged into Retroviral Particles Produced by the Human Germ Cell Tumor Line Tera-1 and Originate Mainly from a Provirus on Chromosome 22q11.21

2008 ◽  
Vol 82 (20) ◽  
pp. 10008-10016 ◽  
Author(s):  
Klemens Ruprecht ◽  
Humberto Ferreira ◽  
Aline Flockerzi ◽  
Silke Wahl ◽  
Marlies Sauter ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Endogenous Retrovirus ◽  
Cell Tumor ◽  
Human Endogenous Retrovirus ◽  
Tumor Line ◽  
Gag Protein ◽  
Rna Transcripts ◽  
Encoded Particles ◽  
Human Germ Cell Tumor

ABSTRACT The human germ cell tumor line Tera-1 produces retroviral particles which are encoded by the human endogenous retrovirus family HERV-K(HML-2). We show here, by quantitative reverse transcriptase PCR, that HML-2 gag and env RNA transcripts are selectively packaged into Tera-1 retroviral particles, whereas RNAs from cellular housekeeping genes and from other HERV families (HERV-H and HERV-W) are nonselectively copackaged. Assignment of cloned HML-2 gag and env cDNAs from Tera-1 retroviral particles to individual HML-2 loci in the human genome demonstrated that HML-2 RNA transcripts packaged into Tera-1 retroviral particles originate almost exclusively from an HML-2 provirus on chromosome 22q11.21. Based on relative cloning frequencies, this provirus was the most active among a total of eight transcribed HML-2 loci identified in Tera-1 cells. These data suggest that at least one HML-2 element, that is, the HML-2 provirus on 22q11.21, has retained the capacity for packaging RNA into HML-2-encoded retroviral particles. Given its elevated transcriptional activity and the presence of a full-length Gag open reading frame, the 22q11.21 HML-2 provirus may also significantly contribute to Gag protein and thus particle production in Tera-1 cells. Our findings provide important clues to the generation and biological properties of HML-2-encoded particles. In addition, copackaging of non-HML-2 HERV transcripts in HML-2-encoded particles should inform the debate about endogenous retroviral particles putatively encoded by non-HML-2 HERV families that have previously been described for other human diseases, such as multiple sclerosis.

Sensitivity of human germ-cell-tumor cell lines to human interferons

1987 ◽  
Vol 33 (3) ◽  
pp. 266-269 ◽  
Author(s):  
Sowi Sekiya ◽  
Yoshimi Tomita ◽  
Hour-Young Chen ◽  
Makoto Kawata ◽  
Tatsuya Oosaki ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Germ Cell ◽  
Cell Lines ◽  
Germ Cell Tumor ◽  
Cell Tumor ◽  
Tumor Cell Lines ◽  
Human Germ Cell Tumor

Analysis of poly(ADP-ribose) polymerase-1 (PARP1) gene alteration in human germ cell tumor cell lines

2010 ◽  
Vol 197 (1) ◽  
pp. 8-15 ◽  
Author(s):  
Hideki Ogino ◽  
Robert Nakayama ◽  
Hiromi Sakamoto ◽  
Teruhiko Yoshida ◽  
Takashi Sugimura ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Germ Cell ◽  
Cell Lines ◽  
Germ Cell Tumor ◽  
Cell Tumor ◽  
Tumor Cell Lines ◽  
Gene Alteration ◽  
Human Germ Cell Tumor

Ultrastructure of Four Human Germ Cell Tumor-Derived Cell Lines: Effect of 12-0-Tetradecanoyl Phorbol-13-Acetate

1988 ◽  
Vol 6 (4) ◽  
pp. 393-402 ◽  
Author(s):  
Akira Hiraoka ◽  
Nicholas J. Vogelzang ◽  
Michael C. Rosner ◽  
Harvey M. Golomb
Keyword(s):  
Germ Cell ◽  
Cell Lines ◽  
Germ Cell Tumor ◽  
Cell Tumor ◽  
Human Germ Cell Tumor

scholarly journals ErbBs inhibition by lapatinib blocks tumor growth in an orthotopic model of human testicular germ cell tumor

2013 ◽  
Vol 133 (1) ◽  
pp. 235-246 ◽  
Author(s):  
M. Juliachs ◽  
W. Castillo-Ávila ◽  
A. Vidal ◽  
J.M. Piulats ◽  
X. Garcia del Muro ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Germ Cell ◽  
Germ Cell Tumor ◽  
Testicular Germ Cell Tumor ◽  
Cell Tumor ◽  
Orthotopic Model ◽  
Testicular Germ Cell

The anti-mitotic drug griseofulvin induces apoptosis of human germ cell tumor cells through a connexin 43-dependent molecular mechanism

APOPTOSIS ◽  
2013 ◽  
Vol 18 (4) ◽  
pp. 480-491 ◽  
Author(s):  
V. Mauro ◽  
D. Carette ◽  
R. Pontier-Bres ◽  
J. Dompierre ◽  
D. Czerucka ◽  
...  
Keyword(s):  
Germ Cell ◽  
Tumor Cells ◽  
Molecular Mechanism ◽  
Germ Cell Tumor ◽  
Connexin 43 ◽  
Cell Tumor ◽  
Human Germ Cell Tumor
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