scholarly journals ErbBs inhibition by lapatinib blocks tumor growth in an orthotopic model of human testicular germ cell tumor

2013 ◽  
Vol 133 (1) ◽  
pp. 235-246 ◽  
Author(s):  
M. Juliachs ◽  
W. Castillo-Ávila ◽  
A. Vidal ◽  
J.M. Piulats ◽  
X. Garcia del Muro ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Germ Cell ◽  
Germ Cell Tumor ◽  
Testicular Germ Cell Tumor ◽  
Cell Tumor ◽  
Orthotopic Model ◽  
Testicular Germ Cell

Testicular germ cell tumor with pineal metastases

Neurosurgery ◽  
1990 ◽  
pp. 688 ◽  
Author(s):  
B Delahunt ◽  
H H Teoh ◽  
V Balakrishnan ◽  
J N Nacey ◽  
S P Clark
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Testicular Germ Cell Tumor ◽  
Cell Tumor ◽  
Testicular Germ Cell

666 A NOVEL RISK STRATIFICATION SYSTEM FOR CHEMOTHERAPY FAILURE IN TESTICULAR GERM CELL TUMOR

2012 ◽  
Vol 187 (4S) ◽  
Author(s):  
Jessica Lubahn ◽  
Nicholas Cost ◽  
Mehrad Adibi ◽  
Adam Romman ◽  
Ganesh Raj ◽  
...  
Keyword(s):  
Risk Stratification ◽  
Germ Cell ◽  
Germ Cell Tumor ◽  
Testicular Germ Cell Tumor ◽  
Cell Tumor ◽  
Testicular Germ Cell ◽  
Stratification System ◽  
Risk Stratification System

scholarly journals A second independent locus within DMRT1 is associated with testicular germ cell tumor susceptibility

2011 ◽  
Vol 20 (15) ◽  
pp. 3109-3117 ◽  
Author(s):  
Peter A. Kanetsky ◽  
Nandita Mitra ◽  
Saran Vardhanabhuti ◽  
David J. Vaughn ◽  
Mingyao Li ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Testicular Germ Cell Tumor ◽  
Cell Tumor ◽  
Testicular Germ Cell ◽  
Tumor Susceptibility ◽  
Independent Locus

scholarly journals The overexpression of SOX2 affects the migration of human teratocarcinoma cell line NT2/D1

2015 ◽  
Vol 87 (1) ◽  
pp. 389-404 ◽  
Author(s):  
DANIJELA DRAKULIC ◽  
JELENA MARJANOVIC VICENTIC ◽  
MARIJA SCHWIRTLICH ◽  
JELENA TOSIC ◽  
ALEKSANDAR KRSTIC ◽  
...  
Keyword(s):  
Stem Cells ◽  
Tumor Suppressor ◽  
Cancer Stem Cells ◽  
Germ Cell ◽  
Germ Cell Tumor ◽  
Testicular Germ Cell Tumor ◽  
Cell Tumor ◽  
Testicular Germ Cell ◽  
Teratocarcinoma Cell ◽  
Altered Expression

The altered expression of the SOX2 transcription factor is associated with oncogenic or tumor suppressor functions in human cancers. This factor regulates the migration and invasion of different cancer cells. In this study we investigated the effect of constitutive SOX2 overexpression on the migration and adhesion capacity of embryonal teratocarcinoma NT2/D1 cells derived from a metastasis of a human testicular germ cell tumor. We detected that increased SOX2 expression changed the speed, mode and path of cell migration, but not the adhesion ability of NT2/D1 cells. Additionally, we demonstrated that SOX2 overexpression increased the expression of the tumor suppressor protein p53 and the HDM2 oncogene. Our results contribute to the better understanding of the effect of SOX2 on the behavior of tumor cells originating from a human testicular germ cell tumor. Considering that NT2/D1 cells resemble cancer stem cells in many features, our results could contribute to the elucidation of the role of SOX2 in cancer stem cells behavior and the process of metastasis.

scholarly journals Clinicopathological Significance and Antitumor Effect of MPHOSPH1 in Testicular Germ Cell Tumor

2018 ◽  
Vol 9 (23) ◽  
pp. 4440-4448 ◽  
Author(s):  
Tatsuro Abe ◽  
Kenichi Kohashi ◽  
Junkichi Takemoto ◽  
Fumio Kinoshita ◽  
Masatoshi Eto ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Antitumor Effect ◽  
Testicular Germ Cell Tumor ◽  
Cell Tumor ◽  
Testicular Germ Cell ◽  
Clinicopathological Significance
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