scholarly journals Gut microbiota dysbiosis in functional gastrointestinal disorders: Underpinning the symptoms and pathophysiology

JGH Open ◽  
2021 ◽  
Author(s):  
Lai Wei ◽  
Rajan Singh ◽  
Seungil Ro ◽  
Uday C Ghoshal
Keyword(s):  
Gut Microbiota ◽  
Functional Gastrointestinal Disorders ◽  
Gastrointestinal Disorders ◽  
Gut Microbiota Dysbiosis

scholarly journals Gut Microbiota Dysbiosis in Functional Dyspepsia

2020 ◽  
Vol 8 (5) ◽  
pp. 691 ◽  
Author(s):  
Georgios Tziatzios ◽  
Paraskevas Gkolfakis ◽  
Ioannis S. Papanikolaou ◽  
Ruchi Mathur ◽  
Mark Pimentel ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Functional Dyspepsia ◽  
Functional Gastrointestinal Disorders ◽  
Gastrointestinal Disorders ◽  
Motor Disorders ◽  
Therapeutic Approaches ◽  
Gastrointestinal Microbiota ◽  
Complex Interactions ◽  
Intestinal Dysbiosis ◽  
Gut Microbiota Dysbiosis

Functional dyspepsia (FD) is one of the most prevalent chronic functional gastrointestinal disorders. Several distinct pathophysiological mechanisms, including gastro duodenal motor disorders, visceral hypersensitivity, brain-gut interactions, duodenal subtle inflammation, and genetic susceptibility, have been implicated in the pathogenesis of the disease, so far. However, emerging evidence suggests that both quantitative and qualitative disturbances of the gastrointestinal microbiota may also be implicated. In this context, several studies have demonstrated differences of the commensal bacterial community between patients with FD and healthy controls, while others have shown that intestinal dysbiosis might associate with disease’s symptoms severity. Elucidating these complex interactions constituting the microbiota and host crosstalk, may eventually lead to the discovery of novel, targeted therapeutic approaches that may be efficacious in treating the multiple aspects of the disorder. In this review, we summarize the data of the latest research with focus on the association between gut microbiota alterations and host regarding the pathogenesis of FD.

Prevention of functional gastrointestinal disorders in neonates: clinical and socioeconomic impact

2015 ◽  
Vol 6 (2) ◽  
pp. 195-198 ◽  
Author(s):  
F. Indrio ◽  
A. Di Mauro ◽  
A. Di Mauro ◽  
G. Riezzo ◽  
R. Panza ◽  
...  
Keyword(s):  
Risk Factor ◽  
Gut Microbiota ◽  
Crucial Role ◽  
Functional Gastrointestinal Disorders ◽  
Functional Constipation ◽  
Socioeconomic Impact ◽  
Gastrointestinal Disorders ◽  
Infantile Colic ◽  
Probiotic Supplementation ◽  
New Strategy

Infantile colic, gastro-oesophageal reflux and constipation are the most common functional gastrointestinal disorders (FGIDs) affecting infants during the first months of life. Despite infantile colic, functional constipation and regurgitation had a self-limited pattern, they are considered a risk factor for developing different disorders later in life. The pathophysiology of these functional diseases is still controversial but there is growing evidence that an abnormal gut microbiota colonisation may play a crucial role. An early probiotic supplementation could determine a change in colonisation and may represent a new strategy for preventing FGIDs.

scholarly journals Gut-Brain-Microbiota Axis: Antibiotics and Functional Gastrointestinal Disorders

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 389
Author(s):  
Tarkan Karakan ◽  
Ceren Ozkul ◽  
Esra Küpeli Akkol ◽  
Saniye Bilici ◽  
Eduardo Sobarzo-Sánchez ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Clinical Symptoms ◽  
Functional Gastrointestinal Disorders ◽  
Developed Countries ◽  
Gastrointestinal Disorders ◽  
Microbiota Composition ◽  
Functional Disorders ◽  
Visceral Hyperalgesia ◽  
Brain Functions ◽  
Gut Microbiota Composition

Gut microbiota composition and function are major areas of research for functional gastrointestinal disorders. There is a connection between gastrointestinal tract and central nervous system and this is mediated by neurotransmitters, inflammatory cytokines, the vagus nerve and the hypothalamic-pituitary-adrenal axis. Functional gastrointestinal disorders are prevalent diseases affecting more than one third of the population. The etiology of these disorders is not clarified. Visceral hyperalgesia is the main hypothesis for explaining clinical symptoms, however gut-brain axis disorder is a new terminology for functional disorders. In this review, microbiota-gut-brain axis connection pathways and related disorders are discussed. Antibiotics are widely used in developed countries and recent evidence indicates antibiotic-induced dysbiosis as an important factor for functional disorders. Antibiotics exert negative effects on gut microbiota composition and functions. Antibiotic-induced dysbiosis is a major factor for occurrence of post-infectious irritable bowel syndrome. Cognitive and mood disorders are also frequent in functional gastrointestinal disorders. Animal and human trials show strong evidence for the causal relationship between gut microbiota and brain functions. Therapeutic implications of these newly defined pathogenic pathways are also discussed.

Families' Perceived Acceptability of Anxiety-Focused CBT for Functional Gastrointestinal Disorders

2012 ◽  
Author(s):  
Erica D. Sood ◽  
Jennifer Shroff Pendley ◽  
Alicia O. Fisher ◽  
Prateek Wali ◽  
Fernando Del Rosario
Keyword(s):  
Functional Gastrointestinal Disorders ◽  
Gastrointestinal Disorders

Functional gastrointestinal disorders in infancy: impact on infants and family health

2020 ◽  
pp. 36-41
Author(s):  
Yvan Vandenplas ◽  
◽  
Bruno Hauser ◽  
Silvia Salvatore ◽  
◽  
...  
Keyword(s):  
Functional Gastrointestinal Disorders ◽  
Family Health ◽  
Gastrointestinal Disorders

Цель. Функциональные гастроинтестинальные расстройства (ФГИР), такие как колики, запоры и регургитация, встречаются практически у 1/2 младенцев. Целью данной публикации является предоставление врачами современного обзора данных по влиянию ФГИР на здоровье семьи и ребенка, а также практических рекомендаций по ведению данных пациентов. Материалы и методы. Проанализированы руководства и экспертные рекомендации. Результаты. ФГИР являются частой причиной беспокойства родителей и ухудшения качества жизни ребенка и членов семьи. Кроме того, они опре-деляют существенные финансовые затраты родителей, страховых компаний и системы здравоохранения в целом. Первичной задачей ведения мла-денцев с ФГИР является уменьшение выраженности симптомов у ребенка и улучшение качества жизни семьи. В тех случаях, когда тактика ведения не ограничивается успокоением родителей, адекватная диетотерапия может быть рекомендована как эффективный и наиболее безопасный метод. Заключение. К основным задачам специалистов в области здравоохранения при ведении детей с ФГИР относятся успокоение родителей, опре-деление оптимальной тактики диетотерапии и ограничение необоснованного использования медикаментов. Ключевые слова: запор, функциональные гастроинтестинальные расстройства, младенец, младенческие колики, питание, регургитация, рефлюкс. Для цитирования: Vandenplas Y., Hauser B., Salvatore S. Функциональные гастроинтестинальные расстройства: влияние на здоровье ребенка и семьи. Педиатрия. Consilium Medicum. 2020; 1: 36–41. DOI: 10.26442/26586630.2020.1.190721

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