Validation of Electrochemiluminiscence Immunoassay for Ovarian Steroid Determination inRhinella arenarum

2016 ◽  
Vol 325 (4) ◽  
pp. 265-273 ◽  
Author(s):  
Ana Josefina Arias Torres ◽  
José Bernardino Páez ◽  
Liliana Isabel Zelarayán
Keyword(s):  
Ovarian Steroid

Corticotrophin-Releasing-Hormone (CRH) modulates ovarian steroid biosynthesis in human primary granulosa cells

2016 ◽  
Vol 76 (10) ◽  
Author(s):  
S Heublein ◽  
S Hecht ◽  
V Nick ◽  
S Mahner ◽  
C Thaler ◽  
...  
Keyword(s):  
Granulosa Cells ◽  
Steroid Biosynthesis ◽  
Ovarian Steroid ◽  
Releasing Hormone

scholarly journals A large ovarian steroid cell tumor‐not otherwise specified with a unique combination of benign and malignant features as a challenging cause of oligomenorrhea and hirsutism in a 21‐year‐old Syrian female: a case report

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Sawsan Ismail ◽  
Munawar Hraib ◽  
Rana Issa ◽  
Thanaa Alassi ◽  
Zuheir Alshehabi
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Virgin Female ◽  
Cell Tumor ◽  
Diagnostic Methods ◽  
Unique Combination ◽  
Ovarian Steroid ◽  
Not Otherwise Specified ◽  
Steroid Cell Tumor ◽  
Rare Category

Abstract Background Ovarian steroid cell tumors represent a rare category of sex cord-stromal tumors that constitute less than 0.1% of all ovarian tumors. These neoplasms are classified into three main subtypes according to the cell of origin: Leidyg cell tumors, stromal luteomas, and steroid cell tumors not otherwise specified (SCTs-NOS). The latter subtype is defined as a neoplasm of an uncertain lineage that mostly affects middle-aged women, whereas it’s rare in younger ages. Case presentation We report a case of a 21-year-old virgin female who presented to our hospital with complaints of mild abdominal pain, hirsutism, and oligomenorrhea for more than a year. Before her current admission, the patient had attended an external gynecologic clinic where she had been prescribed oral contraceptives to regulate her periods. Nevertheless, on presentation to our institution, physical examination revealed abdominal tenderness with a palpable pelvic mass and mild hirsutism in the thigh. Ultrasonography demonstrated a large left ovarian mass measuring 154 × 104 mm, and compressing the uterus. Therefore, a unilateral salpingo-oophorectomy was performed, and interestingly, pathologic examination of the large aforementioned mass alongside with immunohistochemical correlation revealed the diagnosis of a large ovarian steroid cell tumor-not otherwise specified with a unique combination of benign and malignant features. Conclusions Although ovarian steroid cell tumors represent a rare category, they must be considered in the differential diagnosis for mild virilization symptoms in young females due to the importance of early diagnosis and management. In this manuscript, we aimed to present the first case report from Syria that highlights the crucial role of detailed morphological examination for challenging cases despite the difficulties in differential diagnosis, and the absence of ancillary techniques. Furthermore, we managed to discuss a brief review of diagnostic methods, histological characteristics, and treatment recommendations.

Ovarian steroid cell tumor, not otherwise specified: A clinicopathological and immunohistochemical experience of 12 cases

2014 ◽  
Vol 41 (3) ◽  
pp. 424-431 ◽  
Author(s):  
Saroona Haroon ◽  
Romana Idrees ◽  
Saira Fatima ◽  
Aisha Memon ◽  
Naila Kayani
Keyword(s):  
Cell Tumor ◽  
Ovarian Steroid ◽  
Not Otherwise Specified ◽  
Steroid Cell Tumor

The effect of acute immuno-neutralisation of inhibin in ewes during the early luteal phase of the oestrous cycle on ovarian hormone secretion and follicular development

1995 ◽  
Vol 145 (3) ◽  
pp. 479-490 ◽  
Author(s):  
B K Campbell ◽  
B M Gordon ◽  
C G Tsonis ◽  
R J Scaramuzzi
Keyword(s):  
Luteal Phase ◽  
Follicular Development ◽  
Experimental Period ◽  
Ovarian Follicles ◽  
Passive Immunisation ◽  
Follicle Development ◽  
Ovarian Steroid ◽  
Blood Samples ◽  
Steroid Secretion ◽  
Antibody Titres

Abstract Ewes with ovarian autotransplants received either inhibin antiserum (10 ml i.v. raised in sheep against recombinant 32 kDa human inhibin; n=6) or sheep serum (10 ml i.v.; n=5) on day 3 of the luteal phase with additional daily injections (1 ml i.v.) from 48 h after the initial bolus until day 13. Jugular and ovarian venous blood samples were taken 4-hourly over days 2–13 of the luteal phase. Blood samples were also taken at more frequent intervals (every 10–15 min for 2–3 h) to examine pulsatile secretory responses from the ovary to endogenous and gonadotrophin-releasing hormone-induced (150 ng i.m.) LH pulses on days 4, 6, 8, 10 and 12 of the luteal phase. Plasma FSH levels, ovarian steroid secretion and ovarian follicular development were measured. The ovarian follicle population was estimated daily by real time ultrasound scanning. Immunisation against inhibin resulted in a 3- to 4-fold increase (P<0·001) in plasma FSH levels within 8 h with levels remaining elevated over controls for 6–7 days. Within 24 h of immunisation there was an increase in the number of small ovarian follicles (P<0·05) and by 3 days after treatment immunised ewes had 4–6 large ovarian follicles/ewe with this increase in the total number of large follicles being maintained for the rest of the experimental period (P<0·05). Mean ovarian oestradiol secretion during intensive bleeds was not different from controls 24 h after immunisation, but by 3 days after immunisation it was elevated 4- to 5-fold (P<0·001) over controls with this increase being maintained throughout the experiment. Similar responses to immunisation against inhibin in androstenedione secretion were observed although mean androstenedione secretion was not elevated until 7 days after treatment. In vitro antibody titres in immunised ewes remained elevated but declined steadily (P<0·001) over the experimental period. We conclude that the initial stimulation of follicle development and ovarian steroid secretion following passive immunisation against inhibin can be attributed to increased blood FSH. However, the fact that with time FSH declined but increased follicle development was sustained, despite maintenance of high circulating antibody titres, suggests that on a longer term basis inhibin immunisation may stimulate ovarian function by interfering with the modulation of follicle development by inhibin at an ovarian level. Journal of Endocrinology (1995) 145, 479–490

scholarly journals Hirsutism with virilization in a postmenopausal woman due to a rare ovarian steroid cell tumor

2010 ◽  
Vol 76 (2) ◽  
pp. 216 ◽  
Author(s):  
SanjivV Choudhary ◽  
PankajJ Banode ◽  
Arvind Bhake ◽  
Sankalp Dwivedi ◽  
Sumit Gupta ◽  
...  
Keyword(s):  
Postmenopausal Woman ◽  
Cell Tumor ◽  
Ovarian Steroid ◽  
Steroid Cell Tumor
Sign in / Sign up

Export Citation Format

Share Document