Measuring (biological) materials mechanics with atomic force microscopy. 2. Influence of the loading rate and applied force (colloidal particles)

Author(s):  
Andreas Weber ◽  
Barbara Zbiral ◽  
Jagoba Iturri ◽  
Rafael Benitez ◽  
José L. Toca‐Herrera
2019 ◽  
Vol 82 (9) ◽  
pp. 1392-1400 ◽  
Author(s):  
Andreas Weber ◽  
Jagoba Iturri ◽  
Rafael Benitez ◽  
José L. Toca‐Herrera

2003 ◽  
Vol 18 (4) ◽  
pp. 755-757 ◽  
Author(s):  
W. H. Jiang ◽  
M. Atzmon

Plastic deformation of amorphous Al90Fe5Gd5 was investigated using nanoindentation and atomic force microscopy. While serrated flow was detected only at high loading rates, shear bands were observed for all loading rates, ranging from 1 to 100 nm/s. However, the details of shear-band formation depend on the loading rate.


2018 ◽  
Vol 122 (16) ◽  
pp. 4592-4599 ◽  
Author(s):  
Ken-ichi Amano ◽  
Taira Ishihara ◽  
Kota Hashimoto ◽  
Naoyuki Ishida ◽  
Kazuhiro Fukami ◽  
...  

Scanning ◽  
2019 ◽  
Vol 2019 ◽  
pp. 1-25 ◽  
Author(s):  
Andreas Stylianou ◽  
Stylianos-Vasileios Kontomaris ◽  
Colin Grant ◽  
Eleni Alexandratou

Atomic force microscopy (AFM) is an easy-to-use, powerful, high-resolution microscope that allows the user to image any surface and under any aqueous condition. AFM has been used in the investigation of the structural and mechanical properties of a wide range of biological matters including biomolecules, biomaterials, cells, and tissues. It provides the capacity to acquire high-resolution images of biosamples at the nanoscale and allows at readily carrying out mechanical characterization. The capacity of AFM to image and interact with surfaces, under physiologically relevant conditions, is of great importance for realistic and accurate medical and pharmaceutical applications. The aim of this paper is to review recent trends of the use of AFM on biological materials related to health and sickness. First, we present AFM components and its different imaging modes and we continue with combined imaging and coupled AFM systems. Then, we discuss the use of AFM to nanocharacterize collagen, the major fibrous protein of the human body, which has been correlated with many pathological conditions. In the next section, AFM nanolevel surface characterization as a tool to detect possible pathological conditions such as osteoarthritis and cancer is presented. Finally, we demonstrate the use of AFM for studying other pathological conditions, such as Alzheimer’s disease and human immunodeficiency virus (HIV), through the investigation of amyloid fibrils and viruses, respectively. Consequently, AFM stands out as the ideal research instrument for exploring the detection of pathological conditions even at very early stages, making it very attractive in the area of bio- and nanomedicine.


Open Physics ◽  
2011 ◽  
Vol 9 (5) ◽  
Author(s):  
Magdalena Ulmeanu ◽  
Iuliana Iordache ◽  
Mihaela Filipescu ◽  
Valentin Craciun ◽  
Simona Pinzaru ◽  
...  

AbstractExperimental studies on patterning hexagonal Ge nanostructures have been conducted on Si substrates through deposition of Ge with colloidal particles as a mask. The deposited Ge thin film possesses, according to the X-ray diffraction measurements, in plane texture, being epitaxial and aligned with the (111) Si substrate. The size distribution of the patterned Ge nanostructures is narrow, as indicated by the atomic force microscopy and scanning electron microscopy measurements. We have obtained Ge nanostructures with lateral dimension of 490 nm (height 12 nm), 200 nm (height 6 nm) and 82 nm (height 6 nm) by using different sizes of polystyrene spheres. We have performed in depth studies of the Ge nanostructures’ behavior due to thermal and rapid thermal post-annealing processes. FT micro-Raman spectroscopy shows that there is no Si intermixing during the annealing process. In order to quantify the changes in the height and lateral dimension, we have performed atomic force microscopy and white light interferometry analysis. The changes in shape and the decrease in the area of a cross-section of Ge nanostructure will be discussed in respect to similar results shown in the literature for Ge thin films during the annealing process.


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