Analysis of the atomic force microscopy vibration behavior using the Timoshenko theory by multi‐scale method in the air environment

2019 ◽  
Vol 82 (10) ◽  
pp. 1787-1801
Author(s):  
A. H. Korayem ◽  
F. Imani ◽  
Moharram H. Korayem
Keyword(s):  
Atomic Force Microscopy ◽  
Timoshenko Theory ◽  
Force Microscopy ◽  
Multi Scale ◽  
Scale Method ◽  
Vibration Behavior ◽  
Atomic Force

scholarly journals High-speed atomic force microscopy highlights new molecular mechanism of daptomycin action

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Francesca Zuttion ◽  
Adai Colom ◽  
Stefan Matile ◽  
Denes Farago ◽  
Frédérique Pompeo ◽  
...  
Keyword(s):  
Atomic Force Microscopy ◽  
High Speed ◽  
Molecular Mechanisms ◽  
Molecular Level ◽  
Force Microscopy ◽  
Multi Scale ◽  
Atomic Force ◽  
Level Information ◽  
Bacterial Lipid ◽  
Membrane Deformations

AbstractThe increase in speed of the high-speed atomic force microscopy (HS-AFM) compared to that of the conventional AFM made possible the first-ever visualisation at the molecular-level of the activity of an antimicrobial peptide on a membrane. We investigated the medically prescribed but poorly understood lipopeptide Daptomycin under infection-like conditions (37 °C, bacterial lipid composition and antibiotic concentrations). We confirmed so far hypothetical models: Dap oligomerization and the existence of half pores. Moreover, we detected unknown molecular mechanisms: new mechanisms to form toroidal pores or to resist Dap action, and to unprecedently quantify the energy profile of interacting oligomers. Finally, the biological and medical relevance of the findings was ensured by a multi-scale multi-nativeness—from the molecule to the cell—correlation of molecular-level information from living bacteria (Bacillus subtilis strains) to liquid-suspended vesicles and supported-membranes using electron and optical microscopies and the lipid tension probe FliptR, where we found that the cells with a healthier state of their cell wall show smaller membrane deformations.

Electrostatic Forces on the Surface of Metals as Measured by Atomic Force Microscopy

2000 ◽  
Vol 10 (1-2) ◽  
pp. 15
Author(s):  
Eugene Sprague ◽  
Julio C. Palmaz ◽  
Cristina Simon ◽  
Aaron Watson
Keyword(s):  
Atomic Force Microscopy ◽  
Electrostatic Forces ◽  
Force Microscopy ◽  
Atomic Force
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