Remodeling of extracellular matrix in gastric ulceration

2001 ◽  
Vol 53 (6) ◽  
pp. 396-408 ◽  
Author(s):  
M. Shahin ◽  
J.W. Konturek ◽  
T. Pohle ◽  
D. Schuppan ◽  
H. Herbst ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Gastric Ulceration ◽  
Remodeling Of Extracellular Matrix

scholarly journals A High-Throughput Workflow to Study Remodeling of Extracellular Matrix-Based Microtissues

2019 ◽  
Vol 25 (1) ◽  
pp. 25-36 ◽  
Author(s):  
Alexandra L. Crampton ◽  
Katherine A. Cummins ◽  
David K. Wood
Keyword(s):  
Extracellular Matrix ◽  
High Throughput ◽  
Remodeling Of Extracellular Matrix

scholarly journals Peptide hormone relaxin: from molecular effects to clinical results

2021 ◽  
Vol 20 (1) ◽  
pp. 89-96
Author(s):  
O. V. Prokhorova ◽  
A. A. Olina ◽  
G. Kh. Tolibova ◽  
T. G. Tral
Keyword(s):  
Extracellular Matrix ◽  
Current System ◽  
Peptide Hormone ◽  
Clinical Results ◽  
Scientific Publications ◽  
Vitro Fertilization ◽  
Extracellular Matrix Components ◽  
Clinically Significant ◽  
Remodeling Of Extracellular Matrix

Introduction. The peptide hormone relaxin, which is produced by cells of the corpus luteum during and outside pregnancy, has a huge number of clinically significant effects, mediating many biological mechanisms, including antifibrotic, vasodilatory, angiogenic, anti-inflammatory and antiapoptotic effects.Purpose of the study: based on the study of modern literature data, to analyze the results of scientific research, representing the current system of views on the physiological and pathophysilogical effects of relaxin.Materials and methods. A study f scientific publications for the period from 2005 to 2020 in e PubMed and Elibrary databases was carried out using the keywords: relaxin, pregnancy, relaxin signaling pathway, reproductive system, extracellular matrix.Results and Discussion. The study of modern views on the physiology of relaxin has shown that this hormone mediates its effects by binding to the specific receptor RXFP1, which is localized in a large number of reproductive nonproductive tissues. Relaxin performs many functions related to the remodeling of the extracellular matrix and vasculature. The main uterotropic effects of this peptide include stimulation of growth and vascularization of the uterus, remodeling of extracellular matrix components, and regulation of vascular endothelial growth factor in preparation for implantation.Conclusion. The progress of the last decade in understanding the biochemistry of the hormone relaxin has formed the basis for a deeper penetration into all the variety of its physiological roles. The participation of relaxin in the mechanisms of relaxation of the myometrium during pregnancy, remodeling of the connective tissue of target organs in the antenatal period creases its potential clinical significance. The prospect of a possible therapeutic use of relaxin preparations in stimulating antenatal transformation of the cervix, in vitro fertilization, therapy of preeclampsia, acute heart failure and myocardial ischemia turns it into a potential therapeutic agent for these pathological conditions.

Interleukin-10 Suppresses Proliferation and Remodeling of Extracellular Matrix of Cultured Human Skin Fibroblasts

2004 ◽  
Vol 36 (1) ◽  
pp. 39-44 ◽  
Author(s):  
A. Moroguchi ◽  
K. Ishimura ◽  
K. Okano ◽  
H. Wakabayashi ◽  
T. Maeba ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Human Skin ◽  
Interleukin 10 ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts ◽  
Remodeling Of Extracellular Matrix

EP-1814: Study of radiation-induced damage and remodeling of extracellular matrix of rectum and bladder by optical methods

2014 ◽  
Vol 111 ◽  
pp. S294-S295
Author(s):  
M. Kochueva ◽  
N. Ignatjeva ◽  
O. Zakharkina ◽  
E. Sergeeva ◽  
V. Kamensky ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Optical Methods ◽  
Radiation Induced ◽  
Remodeling Of Extracellular Matrix

Remodeling of Extracellular Matrix Patch used for Carotid Artery Repair

2012 ◽  
Vol 175 (1) ◽  
pp. e25-e34 ◽  
Author(s):  
Anna Fallon ◽  
Traci Goodchild ◽  
Ruoya Wang ◽  
Robert G. Matheny
Keyword(s):  
Extracellular Matrix ◽  
Carotid Artery ◽  
Remodeling Of Extracellular Matrix ◽  
Matrix Patch

scholarly journals Thrombospondin-1 contributes to slower aortic aneurysm growth by inhibiting maladaptive remodeling of extracellular matrix

2017 ◽  
Vol 131 (12) ◽  
pp. 1283-1285 ◽  
Author(s):  
Mamoru Satoh ◽  
Takahito Nasu ◽  
Takuya Osaki ◽  
Sho Hitomi
Keyword(s):  
Extracellular Matrix ◽  
Aortic Aneurysm ◽  
Recent Work ◽  
Mouse Models ◽  
Causal Relation ◽  
Clinical Science ◽  
Thrombospondin 1 ◽  
Aneurysm Growth ◽  
Remodeling Of Extracellular Matrix

In this issue of Clinical Science, Krishna and colleagues describe recent work on thrombospondin-1 (TSP-1) maturation and its association with slower growth of aortic aneurysm in TSP-1 knockdown mouse models. The authors conclude that TSP-1 deficiency promotes maladaptive remodeling of the extracellular matrix (ECM) leading to accelerated aortic aneurysm progression. We comment on a causal relation between TSP-1 and the progression of aortic aneurysm.

scholarly journals Late remodeling of extracellular matrix after acute inflammatory injury or chronic distension

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Iryna Hirata Prist ◽  
Alessandra Grassi Salles ◽  
Thais M. Lima Salgado ◽  
Heraldo Possolo Souza
Keyword(s):  
Extracellular Matrix ◽  
Inflammatory Injury ◽  
Remodeling Of Extracellular Matrix
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