Early life exposure to hypercaloric diet impairs eating behavior during weaning: The role of BDNF signaling and astrocyte marks

2020 ◽  
Vol 80 (7) ◽  
pp. 667-678
Author(s):  
Roberta Passos Palazzo ◽  
Iraci L. S. Torres ◽  
Ágnis Iohana Grefenhagen ◽  
Bruno Batista Silva ◽  
Louisiana Carolina Ferreira Meireles ◽  
...  
Keyword(s):  
Eating Behavior ◽  
Early Life ◽  
Early Life Exposure ◽  
Bdnf Signaling ◽  
Hypercaloric Diet

scholarly journals Long-Term Effects of Early-Life Exposure to Environmental Oestrogens on Ovarian Function: Role of Epigenetics

2014 ◽  
Vol 26 (9) ◽  
pp. 613-624 ◽  
Author(s):  
G. Cruz ◽  
W. Foster ◽  
A. Paredes ◽  
K. D. Yi ◽  
M. Uzumcu
Keyword(s):  
Early Life ◽  
Ovarian Function ◽  
Long Term Effects ◽  
Early Life Exposure

scholarly journals Vertically transferred maternal immune cells promote neonatal immunity against early life infections

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Ina Annelies Stelzer ◽  
Christopher Urbschat ◽  
Steven Schepanski ◽  
Kristin Thiele ◽  
Ioanna Triviai ◽  
...  
Keyword(s):  
Immune Cells ◽  
Early Life ◽  
Functional Role ◽  
Respiratory Infections ◽  
Human Cord Blood ◽  
Hematopoietic Stem ◽  
Immune Development ◽  
Early Life Exposure ◽  
First Year Of Life

AbstractDuring mammalian pregnancy, immune cells are vertically transferred from mother to fetus. The functional role of these maternal microchimeric cells (MMc) in the offspring is mostly unknown. Here we show a mouse model in which MMc numbers are either normal or low, which enables functional assessment of MMc. We report a functional role of MMc in promoting fetal immune development. MMc induces preferential differentiation of hematopoietic stem cells in fetal bone marrow towards monocytes within the myeloid compartment. Neonatal mice with higher numbers of MMc and monocytes show enhanced resilience against cytomegalovirus infection. Similarly, higher numbers of MMc in human cord blood are linked to a lower number of respiratory infections during the first year of life. Our data highlight the importance of MMc in promoting fetal immune development, potentially averting the threats caused by early life exposure to pathogens.

Effect of different helminth extracts on the development of asthma in mice: The influence of early-life exposure and the role of IL-10 response

2015 ◽  
Vol 156 ◽  
pp. 95-103 ◽  
Author(s):  
P.M. Pitrez ◽  
L.P. Gualdi ◽  
G.L. Barbosa ◽  
S. Sudbrack ◽  
D. Ponzi ◽  
...  
Keyword(s):  
Early Life ◽  
Early Life Exposure

scholarly journals Role of early life exposure and environment on neurodegeneration: implications on brain disorders

2014 ◽  
Vol 3 (1) ◽  
pp. 9 ◽  
Author(s):  
Shweta Modgil ◽  
Debomoy K Lahiri ◽  
Vijay L Sharma ◽  
Akshay Anand
Keyword(s):  
Early Life ◽  
Brain Disorders ◽  
Early Life Exposure

Chemically Contaminated Eel Fed to Pregnant and Lactating Mouse Dams Causes Hyperactivity in Their Offspring

2016 ◽  
Vol 86 (1-2) ◽  
pp. 36-47 ◽  
Author(s):  
Imen Dridi ◽  
Nidhal Soualeh ◽  
Torsten Bohn ◽  
Rachid Soulimani ◽  
Jaouad Bouayed
Keyword(s):  
Open Field ◽  
Early Life ◽  
Home Cage ◽  
Anguilla Anguilla ◽  
Acetylcholinesterase Activity ◽  
Female Offspring ◽  
Significant Inhibition ◽  
Standard Diet ◽  
Early Life Exposure ◽  
Cage Test

Abstract.This study examined whether perinatal exposure to polluted eels (Anguilla anguilla L.) induces changes in the locomotor activity of offspring mice across lifespan (post-natal days (PNDs) 47 – 329), using the open field and the home cage activity tests. Dams were exposed during gestation and lactation, through diets enriched in eels naturally contaminated with pollutants including PCBs. Analysis of the eel muscle focused on the six non-dioxin-like (NDL) indicator PCBs (Σ6 NDL-PCBs: 28, 52, 101, 138, 153 and 180). Four groups of dams (n = 10 per group) received either a standard diet without eels or eels (0.8 mg/kg/day) containing 85, 216, or 400 ng/kg/day of ϵ6 NDL-PCBs. The open field test showed that early-life exposure to polluted eels increased locomotion in female offspring of exposed dams but not in males, compared to controls. This hyperlocomotion appeared later in life, at PNDs 195 and 329 (up to 32 % increase, p < 0.05). In addition, overactivity was observed in the home cage test at PND 305: exposed offspring females showed a faster overall locomotion speed (3.6 – 4.2 cm/s) than controls (2.9 cm/s, p <0.05); again, males remained unaffected. Covered distances in the home cage test were only elevated significantly in offspring females exposed to highest PCB concentrations (3411 ± 590 cm vs. 1377 ± 114 cm, p < 0.001). These results suggest that early-life exposure to polluted eels containing dietary contaminants including PCBs caused late, persistent and gender-dependent neurobehavioral hyperactive effects in offspring mice. Furthermore, female hyperactivity was associated with a significant inhibition of acetylcholinesterase activity in the hippocampus and the prefrontal cortex.

Prenatal and Early-Life Exposure to Indoor Air-Polluting Factors and Allergic Sensitization at 2 Years of Age

PEDIATRICS ◽  
2020 ◽  
Vol 146 (Supplement 4) ◽  
pp. S332.2-S333
Author(s):  
Suzanne R. Kochis ◽  
Jennifer Dantzer
Keyword(s):  
Indoor Air ◽  
Early Life ◽  
Allergic Sensitization ◽  
Early Life Exposure

Early Life Exposure to Antibiotic Alters Energy Balance during Chronic High-Fat Feeding in Adult Male and Female Mice

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1999-P ◽  
Author(s):  
HYE LIM NOH ◽  
SUJIN SUK ◽  
RANDALL H. FRIEDLINE ◽  
KUNIKAZU INASHIMA ◽  
DUY A. TRAN ◽  
...  
Keyword(s):  
Energy Balance ◽  
Adult Male ◽  
Early Life ◽  
High Fat ◽  
Male And Female ◽  
Female Mice ◽  
Early Life Exposure ◽  
Fat Feeding

scholarly journals Early Origins of Body Mass in Later Life: Examining Childhood Risks and Adult Pathways

2021 ◽  
pp. 002214652110054
Author(s):  
Sarah A. Mustillo ◽  
Miao Li ◽  
Patricia Morton ◽  
Kenneth F. Ferraro
Keyword(s):  
Physical Activity ◽  
Body Mass ◽  
Health Risks ◽  
Early Life ◽  
Life Experiences ◽  
Later Life ◽  
Childhood Experiences ◽  
Older Adulthood ◽  
Early Life Exposure ◽  
Nationally Representative

Prior research reveals that negative early-life experiences play a major role in the development of obesity in later life, but few studies identify mechanisms that alter the lifetime risk of obesity. This study examines the influence of negative childhood experiences on body mass index (BMI) and obesity (BMI ≥30) during older adulthood and the psychosocial and behavioral pathways involved. Using a nationally representative sample, we examine the influence of cumulative misfortune as well as five separate domains of misfortune on BMI and obesity. Results show that four of the five domains are associated with BMI and obesity either directly, indirectly, or both. The influence of cumulative misfortune on the outcomes is mediated by three adult factors: socioeconomic status, depressive symptoms, and physical activity. The mediators identified here provide targets for intervention among older adults to help offset the health risks of excess BMI attributable of early-life exposure to misfortune.

Early life exposure to phthalates and the development of childhood asthma among Canadian children

2021 ◽  
pp. 110981
Author(s):  
Garthika Navaranjan ◽  
Miriam L. Diamond ◽  
Shelley A. Harris ◽  
Liisa Jantunen ◽  
Sarah Bernstein ◽  
...  
Keyword(s):  
Childhood Asthma ◽  
Early Life ◽  
Early Life Exposure
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