PR domaincontaining protein 12 ( prdm12 ) is a downstream target of the transcription factor zic1 during cellular differentiation in the central nervous system

2020 ◽  
Vol 80 (6) ◽  
pp. 528-537
Author(s):  
Md Mahfujur Rahman ◽  
In‐Shik Kim ◽  
Dongchoon Ahn ◽  
Hyun‐Jin Tae ◽  
Byung‐Yong Park
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Transcription Factor ◽  
Cellular Differentiation ◽  
Downstream Target ◽  
The Central Nervous System

scholarly journals Drosophila Zic family member odd-paired is needed for adult post-ecdysis maturation

Open Biology ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 190245
Author(s):  
Eléanor Simon ◽  
Sergio Fernández de la Puebla ◽  
Isabel Guerrero
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Transcription Factor ◽  
Drosophila Melanogaster ◽  
Family Member ◽  
Ectopic Expression ◽  
Functional Conservation ◽  
The Central Nervous System ◽  
Behavioural Sequence

Specific neuropeptides regulate in arthropods the shedding of the old cuticle (ecdysis) followed by maturation of the new cuticle. In Drosophila melanogaster , the last ecdysis occurs at eclosion from the pupal case, with a post-eclosion behavioural sequence that leads to wing extension, cuticle stretching and tanning. These events are highly stereotyped and are controlled by a subset of crustacean cardioactive peptide (CCAP) neurons through the expression of the neuropeptide Bursicon (Burs). We have studied the role of the transcription factor Odd-paired (Opa) during the post-eclosion period. We report that opa is expressed in the CCAP neurons of the central nervous system during various steps of the ecdysis process and in peripheral CCAP neurons innerving the larval muscles involved in adult ecdysis. We show that its downregulation alters Burs expression in the CCAP neurons. Ectopic expression of Opa, or the vertebrate homologue Zic2 , in the CCAP neurons also affects Burs expression, indicating an evolutionary functional conservation. Finally, our results show that, independently of its role in Burs regulation, Opa prevents death of CCAP neurons during larval development.

scholarly journals RFX4 transcription factor regulates IFT172 expression, cilia formation and dorsoventral patterning of the central nervous system

2007 ◽  
Vol 306 (1) ◽  
pp. 360
Author(s):  
Amir M. Ashique ◽  
Mattias Karlen ◽  
Youngshik Choe ◽  
Johan Ericson ◽  
John L. Rubenstein ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Transcription Factor ◽  
Dorsoventral Patterning ◽  
Cilia Formation ◽  
The Central Nervous System

scholarly journals The Central Nervous System-Restricted Transcription Factor Olig2 Opposes p53 Responses to Genotoxic Damage in Neural Progenitors and Malignant Glioma

Cancer Cell ◽  
2011 ◽  
Vol 19 (3) ◽  
pp. 359-371 ◽  
Author(s):  
Shwetal Mehta ◽  
Emmanuelle Huillard ◽  
Santosh Kesari ◽  
Cecile L. Maire ◽  
Diane Golebiowski ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Transcription Factor ◽  
Malignant Glioma ◽  
Neural Progenitors ◽  
Genotoxic Damage ◽  
The Central Nervous System

scholarly journals The Pancreatic Homeodomain Transcription Factor IDX1/IPF1 Is Expressed in Neural Cells during Brain Development

Endocrinology ◽  
1999 ◽  
Vol 140 (8) ◽  
pp. 3857-3860 ◽  
Author(s):  
Beatriz Perez-Villamil ◽  
Petra T. Schwartz ◽  
Mario Vallejo
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Transcription Factor ◽  
Neural Cells ◽  
Homeodomain Protein ◽  
Mobility Shift ◽  
Homeodomain Transcription Factor ◽  
Nuclear Extracts ◽  
The Central Nervous System ◽  
Electrophoretic Mobility Shift Assays

Abstract Expression of the homeodomain transcription factor IDX1/IPF1 has been shown to be restricted to cells in the developing foregut that form the pancreatic primordium. In the adult, IDX1/IPF1 is expressed in the duodenum and pancreatic islets. The IDX1/IPF1 gene is required for pancreatic development, and in the human, heterozygous mutations have been linked to diabetes mellitus. In the present communication, we report that IDX1/IPF1 is expressed in discrete cells of the rat central nervous system during embryonic development. Using RT-PCR, IDX1/IPF1 mRNA was detected in neural precursor RC2.E10 cells, as well as in both forebrain and hindbrain of developing rats at embryonic day 15 (E15). The presence of IDX1/IPF1 protein was confirmed by Western immunoblotting. Immunohistochemical analyses of sagittal sections of E15 rats demonstrated the presence of scattered IDX1/IPF1-immunopositive cells in the forebrain. Finally, electrophoretic mobility shift assays using nuclear extracts from neural cells revealed the presence of IDX1/IPF1 bound to a putative homeodomain protein DNA-binding site present in the promoter of the glial fibrillary acidic protein gene. Our results suggest that IDX1/IPF1 may have previously unsuspected extrapancreatic functions during development of neural cells in the central nervous system.

Inhibition of transcription factor NF-κB in the central nervous system ameliorates autoimmune encephalomyelitis in mice

2006 ◽  
Vol 7 (9) ◽  
pp. 954-961 ◽  
Author(s):  
Geert van Loo ◽  
Rossana De Lorenzi ◽  
Hauke Schmidt ◽  
Marion Huth ◽  
Alexander Mildner ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Transcription Factor ◽  
Autoimmune Encephalomyelitis ◽  
The Central Nervous System
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