scholarly journals Beyond the p factor: Is there a d factor?

JCPP Advances ◽  
2021 ◽  
Author(s):  
Samuele Cortese ◽  
Gonzalo Arrondo ◽  
Christoph Correll ◽  
Marco Solmi
Keyword(s):  
2021 ◽  
Vol 227 (2) ◽  
pp. 137-152
Author(s):  
S. K. Chandra ◽  
R. Sarkar ◽  
Sukalpa Choudhury ◽  
Mrinmoy Jana ◽  
P. S. De ◽  
...  

2021 ◽  
pp. 1-16
Author(s):  
Peter Fonagy ◽  
Chloe Campbell ◽  
Matthew Constantinou ◽  
Anna Higgitt ◽  
Elizabeth Allison ◽  
...  

Abstract This paper proposes a model for developmental psychopathology that is informed by recent research suggestive of a single model of mental health disorder (the p factor) and seeks to integrate the role of the wider social and cultural environment into our model, which has previously been more narrowly focused on the role of the immediate caregiving context. Informed by recently emerging thinking on the social and culturally driven nature of human cognitive development, the ways in which humans are primed to learn and communicate culture, and a mentalizing perspective on the highly intersubjective nature of our capacity for affect regulation and social functioning, we set out a cultural-developmental approach to psychopathology.


Genetics ◽  
1981 ◽  
Vol 98 (3) ◽  
pp. 565-587
Author(s):  
William R Engels

ABSTRACT In its hypermutable state, an unstable singed allele, snw, mutates in the germline to two other alleleic forms at a total frequency usually between 40 and 60%. In its stable state, the mutation rate of snw is essentially zero. Its state depends on an extrachromosomal condition indistinguishable from a property called cytotype previously studied as a component of hybrid dysgenesis. Of the two known systems of hybrid dysgenesis, denoted P-M and I-R, snw hypermutability is determined by the P-M system and appears to be independent of the I-R system. Cytotype, as defined by the control of snw mutability, is self-reproducing in the cytoplasm or nucleoplasm of the germline through at least two generations. However, it is not entirely autonomous, being ultimately determined by the chromosomes after sufficiently many generations of backcrossing. This combination of chromosomal and extrachromosomal transmission agrees well with previous studies on cytotype. Temperature differences have little effect on the mean mutation rates, but they have a pronounced effect on the intrinsic variance among individuals. The latter effect suggests that high temperatures reduce germ-cell survival during the development of dysgenic flies. Chromosomal rearrangements produce no apparent effects on the behavior of snw. Hypermutability is thought to be caused by the excision or other alteration of an inserted genetic element in the snw gene. This element might be a copy of the "P factor," which is though to be a mobile sequence capable of causing female sterility and other dysgenic traits in the P-M system.


1992 ◽  
Vol 293 (3-4) ◽  
pp. 282-286 ◽  
Author(s):  
D.S. Brenner ◽  
R.F. Casten ◽  
W.-T. Chou ◽  
J.-Y. Zhang ◽  
K. Heyde ◽  
...  
Keyword(s):  

Author(s):  
Robbie Duschinsky ◽  
Sarah Foster

The theory of mentalizing and epistemic trust introduced by Peter Fonagy and colleagues at the Anna Freud Centre has been an important perspective on mental health and illness. This book is the first comprehensive account and evaluation of this perspective. The book explores 20 primary concepts that organize the contributions of Fonagy and colleagues: adaptation, aggression, the alien self, culture, disorganized attachment, epistemic trust, hypermentalizing, reflective function, the p-factor, pretend mode, the primary unconscious, psychic equivalence, mental illness, mentalizing, mentalization-based therapy, non-mentalizing, the self, sexuality, the social environment, and teleological mode. The biographical and social context of the development of these ideas is examined. The book also specifies the current strengths and limitations of the theory of mentalizing and epistemic trust, with attention to the implications for both clinicians and researchers.


Author(s):  
Dmitry Semenov ◽  
Anna Sidorova ◽  
Pavel Romanov ◽  
Aleksey Kuvshinov

Abstract The relevance of the study is conditioned by the need to determine the state and residual life duration of high-voltage cable lines to identify faulty and maintainable cables. The aim of the article is to determine a reliable scientifically grounded criterion for assessment of insulation characteristics of the cables in use and to perform a comparative analysis of the results obtained by the traditional method of diagnosing insulation with the results of a new method of assessment by the return voltage. In this regard, the article deals with the issues related to the testing of cables having oil-impregnated paper insulation, as well as with the issue of switching from planned replacement of cables to assessment of their actual state and period of residual life. The authors propose to use the method of examining the cables by the return voltage using the device for testing electrical insulation “UDEI-1” developed at the department of Electrification and Automation of the Nizhny Novgorod State University of Engineering and Economics. The article presents the results of measuring the return voltage of three cables that operated under different conditions. The cables had different technical state. The analysis of the estimation of the residual life of cables by the return voltage was carried out using such criteria as the PIRV polarization index, the LIRV electrical conductivity index, and the P-factor. The P-factor is the physical criterion demonstrating the aging of paper-oil insulation by the shape of the return voltage curve. It represents such characteristics of insulation aging as moistening. To compare the results of testing the cables by the return voltage with the conventional methods of diagnostics and to determine the actual technical condition of power cables, the authors applied the method of spatiotemporal reflectometry and the method of measuring insulation resistance with the determination of such indicators of state as insulation resistance normalized per one kilometer, absorption coefficient, and polarization index. The results of this article confirm that the return voltage gives a qualitative assessment of the state and degree of aging of cables with impregnated paper insulation. The authors proposed a new system for evaluation of cable condition by weighting coefficients. In this approach, the determination of residual life of cables with impregnated paper insulation is based on the values of the return voltage. Application of the new system gives opportunity to improve reliability of the power lines. Recommendations for the further operation of the studied cables are given. The materials of the article are of practical value for carrying out complex assessment of the technical condition of power cables by the return voltage and can be useful for drawing up a schedule for replacement or repair of cable lines depending on their actual state.


1993 ◽  
Vol 7 (2) ◽  
pp. 65-105 ◽  
Author(s):  
Dick Van Kampen

In this article a critical evaluation is given of Eysenck's Psychoticism model. It is argued that in this model two sub‐models can be distinguished, which, contrary to Eysenck's presentation, cannot be regarded as true extensions of each other. With respect to one of these models, the ‚genotypic’︁ P‐model, the theory is criticized in that both schizophrenia and affective psychosis are determined by a common genetic predisposition which can phenotypically manifest itself in variations of P. Instead of this theory, the likelihood is put forward that a high EPQ‐P score, albeit in combination with a high N and a low E score (and notwithstanding the fact that criminals or psychopaths can also obtain high P scores), is (only) related to the schizoid state, and hence, that P seems to be relevant either as a predisposing factor contributing to the development of schizophrenic psychosis, or as a factor on which biological relatives of schizophrenics obtain higher scores on average than normals do. In this respect, Eysenck's theory that the non‐schizoid form of psychopathy can also be found among first‐degree relatives of schizophrenics, and hence, that psychopathy and schizoidia are genetically related, is also criticized. Furthermore, it is argued that Eysenck's EPQ‐P scale is not optimal for measuring those traits of the schizoid personality which are independent of N and/or E. Both arguments regarding the contents of this scale and arguments with respect to the demonstrated lack of invariance of the EPQ‐P factor are adduced to support this statement. Thus, an alternative scale for measuring ‚P’︁ (labelled S or Insensitivity) was designed by us. The S‐scale is based on literature concerning the schizoid state and reflects the results of a series of principal components analyses of (potential) S items, together with N and E items, put into execution with the intention of investigating the invariance of the S factor (and of E and N) with respect to six sample and other parameters. These investigations were carried out on a large, representative sample of the Dutch population. Additional investigations were carried out concerning the reliability and validity of the three newly formed scales. The results of these investigations turned out to be very satisfactory or, in some respects, at least promising. Finally, in this article, comments are made on the nature of the S factor, comparing this dimension with both Eysenck's P factor and the dimensions Agreeableness and Conscientiousness, as proposed, for instance, in McCrae and Costa's version of Nor‐man's 5‐factor model. As against P, the S or Insensitivity factor seems to be only (negatively) related to Agreeableness and not to Conscientiousness. It is also argued that this finding seems to be in accord with the supposed schizoid nature of S and the criticisms levelled at Eysenck's EPQ‐P scale.


1935 ◽  
Vol 62 (3) ◽  
pp. 289-296 ◽  
Author(s):  
M. Ruiz Castaneda

Two substances differing in immunological behavior as well as in certain chemical properties have been isolated from soluble extracts of B. proteus X-19. Both substances appear to be polysaccharides. The first substance is precipitated from X-19 crude extracts by a relatively low percentage of alcohol and electrolytes (from one to two and a half volumes of alcohol). When purified as far as possible, it gives a negative biuret reaction, a positive Molish and has a nitrogen content of 4 per cent. This material, which we call X factor, has the immunological properties of the common antigenic factor in Proteus X-19 and typhus Rickettsiae, described elsewhere. It has the property of precipitating with typhus serum as well as anti-Proteus serum, even after treatment with hot alkali. The second substance we call P factor, suggesting a material which is proper to Proteus X-19 and has nothing to do with the Weil-Felix reaction. It is obtained from the crude extracts of B. proteus X-19 by treating the fluids from which the X factor has been removed with an excess of alcohol (seven to ten volumes, according to electrolytes in solution). The purified material shows a nitrogen content of a little less than 1 per cent, gives a negative biuret and a positive Molish reaction. The P factor produces precipitates with anti-Proteus serum in considerable dilution, but has no effect on typhus serum. It is quickly destroyed on treating with alkali, a fact in accordance with the results already cited, which were obtained by White with whole extracts of B. proteus X-19. The duality of the X-19 extracts seems to be explained by the isolation of two immunologically different factors; one which is alkali-labile and which is proper to B. proteus X-19; and the other which is alkali-stable and is the common antigenic factor in Proteus X-19 and typhus Rickettsiae.


1993 ◽  
Vol 13 (1) ◽  
pp. 80-88 ◽  
Author(s):  
K Tanaka ◽  
J Davey ◽  
Y Imai ◽  
M Yamamoto

A defect in the map3 gene of the fission yeast Schizosaccharomyces pombe causes h+ mating-type-specific sterility. This gene was cloned by complementation. Nucleotide sequence analysis showed that it has a coding capacity of 365 amino acids. The deduced map3 gene product is a putative seven-transmembrane protein and has 20.0% amino acid identity with the a-factor receptor of Saccharomyces cerevisiae, encoded by STE3. It is also homologous with the Ustilago maydis mating pheromone receptors. The map3 gene is expressed in h+ cells but not in h- cells, and the transcripts are induced in response to nitrogen starvation. h+ cells defective in map3 do not respond to purified M-factor. When map3 is expressed ectopically in h- cells, they apparently acquire the ability to respond to the M-factor produced by themselves. The gpa1 gene, which encodes the alpha-subunit of a G-protein presumed to couple with the mating pheromone receptors, is essential for this function of map3. These observations strongly suggest that map3 encodes the M-factor receptor. Furthermore, this study provides strong support for the notion that pheromone signaling is essential for initiation of meiosis in S. pombe and that either M-factor signaling or P-factor signaling alone is sufficient.


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