Subthalamic stimulation improves the cerebral hemodynamic response to the cold pressure test in patients with Parkinson's disease

2012 ◽  
Vol 40 (9) ◽  
pp. 547-553 ◽  
Author(s):  
Tõnu Rätsep ◽  
Toomas Asser
2009 ◽  
Vol 15 (2) ◽  
pp. 94-100 ◽  
Author(s):  
Shih-Jei Tsai ◽  
Shiuan-Chih Chen ◽  
Tsong-Ming Leu ◽  
Chiu-Mei Chen ◽  
Hsi-Hsien Chou ◽  
...  

2004 ◽  
Vol 31 (S 1) ◽  
Author(s):  
B Haslinger ◽  
K Kalteis ◽  
F Alesch ◽  
H Boecker ◽  
AO Ceballos-Baumann

Motor Control ◽  
2004 ◽  
Vol 8 (4) ◽  
pp. 484-499 ◽  
Author(s):  
Jay L. Alberts ◽  
Christopher M. Elder ◽  
Michael S. Okun ◽  
Jerrold L. Vitek

2018 ◽  
Vol 11 (4) ◽  
pp. 867-874 ◽  
Author(s):  
Haidar Salimi Dafsari ◽  
Luisa Weiß ◽  
Monty Silverdale ◽  
Alexandra Rizos ◽  
Prashanth Reddy ◽  
...  

2020 ◽  
Author(s):  
Yvan Vachez ◽  
Marie Bahout ◽  
Robin Magnard ◽  
Pierre-Maxime David ◽  
Carole Carcenac ◽  
...  

ABSTRACTApathy is frequently reported in Parkinson’s disease (PD) patients under subthalamic nucleus deep brain stimulation (STN-DBS). The prevailing clinical view for apathy following STN-DBS is the reduction of dopaminergic medication. However, few clinical reports and recent experimental data suggested the pathogenicity of bilateral STN-DBS on motivation, challenging the leading opinion. Here, we investigate whether bilateralism of STN-DBS influences apathy outcome after STN-DBS, combining pre-clinical and clinical approaches. We assess the motivational effects of chronic unilateral STN-DBS in rats in the exact same conditions having highlighted a loss of motivation under bilateral STN-DBS. Clinical data are obtained by the follow-up of a cohort of parkinsonian patients undergoing unilateral STN-DBS and coming from the clinical center that described apathy related to bilateral STN-DBS itself. Despite an acute effect, which fades rapidly, unilateral STN-DBS did not induce a loss of motivation reminiscent to apathy in rats. In patients, apathy did not increase between the preoperative and the post-operative assessment. Together, those data demonstrate that bilateral but not unilateral STN-DBS can induce a loss of motivation in both rats and patients. This constitutes another evidence of the role of STN-DBS itself for apathy in PD.


2013 ◽  
Vol 6 (5) ◽  
pp. 740-745 ◽  
Author(s):  
Tereza Serranová ◽  
Tomáš Sieger ◽  
Petr Dušek ◽  
Filip Růžička ◽  
Dušan Urgošík ◽  
...  

2019 ◽  
Vol 34 (11) ◽  
pp. 1728-1734 ◽  
Author(s):  
Walid Bouthour ◽  
Matthieu Béreau ◽  
Astrid Kibleur ◽  
André Zacharia ◽  
Emilie Tomkova Chaoui ◽  
...  

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