Process Analytical Technology as Key‐Enabler for Digital Twins in Continuous Biomanufacturing

2021 ◽  
Author(s):  
Axel Schmidt ◽  
Heribert Helgers ◽  
Lara Julia Lohmann ◽  
Florian Vetter ◽  
Alex Juckers ◽  
...  
Keyword(s):  
Process Analytical Technology ◽  
Digital Twins ◽  
Analytical Technology

scholarly journals Digital Twin for Extraction Process Design and Operation

Processes ◽  
2020 ◽  
Vol 8 (7) ◽  
pp. 866 ◽  
Author(s):  
Lukas Uhlenbrock ◽  
Christoph Jensch ◽  
Martin Tegtmeier ◽  
Jochen Strube
Keyword(s):  
Process Analytical Technology ◽  
Extraction Process ◽  
Process Models ◽  
Advanced Process Control ◽  
Manufacturing Optimization ◽  
Innovative Methods ◽  
Digital Twins ◽  
Extraction Processes ◽  
Regulated Industries ◽  
Analytical Technology

Traditional extraction processes of natural product are widespread, especially in regulated industries. Possibilities of extraction development and manufacturing optimization in regulated industries is limited. Regulatory approvals are often based on traditional preparations of phyto-pharmaceuticals. The dependence on traditional processes can result in sub-optimal extraction parameters causing unnecessary costs and product variability. Innovative methods like Quality-by-Design (QbD), including process analytical technology (PAT), open opportunities for manufacturers to cope with regulatory demanded, narrow batch-to-batch variability. In addition, such validated process models represent perfect digital twins which could be utilized for advanced process control and life cycle analysis.

scholarly journals Exploiting Fluorescent Reporter Molecules for Process Analytical Technology (PAT)

2009 ◽  
Vol 63 (3) ◽  
pp. 171-173 ◽  
Author(s):  
Tobias Broger ◽  
Res P. Odermatt ◽  
Pablo Ledergerber ◽  
Bernhard Sonnleitner
Keyword(s):  
Process Analytical Technology ◽  
Fluorescent Reporter ◽  
Analytical Technology

Process analytical technology for bakery industry: A review

2019 ◽  
Vol 42 (5) ◽  
Author(s):  
Rifna E. Jerome ◽  
Sushil K. Singh ◽  
Madhuresh Dwivedi
Keyword(s):  
Process Analytical Technology ◽  
Bakery Industry ◽  
Analytical Technology
Sign in / Sign up

Export Citation Format

Share Document