Influence of imidazolium-based ionic liquids on steroid biotransformation by Arthrobacter simplex

2017 ◽  
Vol 93 (2) ◽  
pp. 426-431 ◽  
Author(s):  
Lifang Wang ◽  
Yanbing Shen ◽  
Mengjiao Liu ◽  
Rui Tang ◽  
Min Wang
Keyword(s):  
Ionic Liquids ◽  
Arthrobacter Simplex ◽  
Steroid Biotransformation

Effect of Natural Cyclodextrins on Cell Growth, Activity and Permeability of Arthrobacter simplex

2015 ◽  
Vol 730 ◽  
pp. 249-253
Author(s):  
Qian Gao ◽  
Yan Bing Shen ◽  
Wei Huang ◽  
Min Wang
Keyword(s):  
Cell Growth ◽  
Dehydrogenase Activity ◽  
Conversion Rate ◽  
Model System ◽  
Cell Permeability ◽  
Cavity Size ◽  
Arthrobacter Simplex ◽  
Steroid Biotransformation ◽  
Growth Activity ◽  
Initial Conversion

In this study, the biotransformation which from cortisone acetate (CA) to prednisone acetate (PA) by Arthrobacter simplex (ASP) was selected as a model system for evaluating the effects of natural cyclodextrins (α-CD, β-CD and γ-CD, referred as CDs) on cell growth, dehydrogenase activity, permeability of Arthrobacter simplex. The results showed that the cavity size of cyclodextrins on ASP cell growth were quite different, the with smaller cavity significantly inhibited ASP growth. CDs reduced the dehydrogenase activity of ASP and increased the cell permeability. Initial conversion rate of cells after treated by CDs were higher than the control cells. The study provided basic datas for the application of cyclodextrin in the steroid biotransformation.

Study on Microbial Transformation of 11α-hydroxy-16,17α-epoxy progesterone in Ionic Liquid/Water Biphasic System by Arthrobacter simplex

2015 ◽  
Vol 723 ◽  
pp. 719-723
Author(s):  
Lu Yu ◽  
Shu Hong Mao ◽  
Shao Xian Ji ◽  
Fu Ping Lu
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Liquid Water ◽  
Microbial Transformation ◽  
Conversion Ratio ◽  
Biphasic System ◽  
Arthrobacter Simplex

Dehydrogenated steroids are usually more effective in treating diseases, compared to their precursors. In this study, toxicity of six ionic liquids to the Arthrobacter simplex was investigated to evaluate the possibility of dehydrogenation of 11α-hydroxy-16,17α-epoxy progesterone in ionic liquid / water biphasic system. Results indicated that ionic liquids displayed higher toxicities to the A. simplex. The followed bio-dehydrogenation in biphasic system, as well as the immobilization investigations in the corresponding system, showed the lower conversion ratio of 11α-hydroxy-16,17α-epoxy progesterone. This maybe indicated the unsuitability of the imidazole-based ionic liquid for the dehydrogenation of A. simplex in the biphasic system.

Investigation of Various Ionic Liquids and Catalyst Materials for Lithium-Oxygen Batteries

2011 ◽  
pp. 110923034559006
Author(s):  
Arnd Garsuch ◽  
D. Michael Badine ◽  
Klaus Leitner ◽  
Luiz H. S. Gasparotto ◽  
Natalia Borisenko ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Lithium Oxygen Batteries
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