Comparison of control strategies for fed-batch culture of hybridoma cells based on on-line monitoring of oxygen uptake rate, optical cell density and glucose concentration

2013 ◽  
Vol 88 (9) ◽  
pp. 1680-1689 ◽  
Author(s):  
Antoni Casablancas ◽  
Xavier Gámez ◽  
Martí Lecina ◽  
Carles Solà ◽  
Jordi J. Cairó ◽  
...  
Keyword(s):  
Oxygen Uptake ◽  
Uptake Rate ◽  
Glucose Concentration ◽  
Oxygen Uptake Rate ◽  
Control Strategies ◽  
Hybridoma Cells ◽  
Fed Batch ◽  
Optical Cell ◽  
On Line ◽  
Fed Batch Culture

Oxygen Transfer Efficiency Measurements Using Off-Gas Techniques

1989 ◽  
Vol 21 (10-11) ◽  
pp. 1295-1300 ◽  
Author(s):  
W. C. Boyle ◽  
B. G. Hellstrom ◽  
L. Ewing
Keyword(s):  
Oxygen Uptake ◽  
Uptake Rate ◽  
Oxygen Transfer ◽  
Oxygen Uptake Rate ◽  
Transfer Efficiency ◽  
Theoretical Development ◽  
Process Conditions ◽  
Uptake Rates ◽  
Oxygen Transfer Efficiency ◽  
On Line

The off-gas technique for measuring oxygen transfer efficiency in aeration tanks under process conditions was proposed as an accurate technique for calibrating or verifying on-line methods used to estimate oxygen uptake rates. The theoretical development of the off-gas technique was presented. Application of this technique in verifying or calibrating existing on-line methods for estimating oxygen uptake rate was presented. Direct application as an on-line method for estimating oxygen uptake rate was also discussed.

A new method for on-line measurement of the volumetric oxygen uptake rate in membrane aerated animal cell cultures

2000 ◽  
Vol 78 (2) ◽  
pp. 139-147 ◽  
Author(s):  
Paul Ducommun ◽  
Pierre-Alain Ruffieux ◽  
Maria-Pilar Furter ◽  
Ian Marison ◽  
Urs von Stockar
Keyword(s):  
Oxygen Uptake ◽  
Cell Cultures ◽  
Uptake Rate ◽  
Oxygen Uptake Rate ◽  
Animal Cell ◽  
New Method ◽  
Line Measurement ◽  
Animal Cell Cultures ◽  
On Line

High density culture of mammalian cells with dynamic perfusion based on on-line oxygen uptake rate measurements

1994 ◽  
Vol 14 (3) ◽  
pp. 183-190 ◽  
Author(s):  
Yun-Seung Kyung ◽  
Madhusudan V. Peshwa ◽  
David M. Gryte ◽  
Wei-Shou Hu
Keyword(s):  
Oxygen Uptake ◽  
Uptake Rate ◽  
Mammalian Cells ◽  
Oxygen Uptake Rate ◽  
High Density ◽  
High Density Culture ◽  
On Line ◽  
Line Oxygen

Oxygen uptake rate of immobilized growing hybridoma cells

1988 ◽  
Vol 29 (2-3) ◽  
pp. 113-118 ◽  
Author(s):  
Yoshihito Shirai ◽  
Kenji Hashimoto ◽  
Hideki Yamaji ◽  
Hiroyuki Kawahara
Keyword(s):  
Oxygen Uptake ◽  
Uptake Rate ◽  
Oxygen Uptake Rate ◽  
Hybridoma Cells
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