scholarly journals Muscle‐to‐fat ratio identifies functional impairments and cardiometabolic risk and predicts outcomes: biomarkers of sarcopenic obesity

2021 ◽  
Author(s):  
Pei‐Chin Yu ◽  
Chia‐Chia Hsu ◽  
Wei‐Ju Lee ◽  
Chih‐Kuang Liang ◽  
Ming‐Yueh Chou ◽  
...  
Keyword(s):  
Cardiometabolic Risk ◽  
Sarcopenic Obesity ◽  
Functional Impairments

scholarly journals Sarcopenia, sarcopenic obesity, and functional impairments in older adults: National Health and Nutrition Examination Surveys 1999-2004

2015 ◽  
Vol 35 (12) ◽  
pp. 1031-1039 ◽  
Author(s):  
John A. Batsis ◽  
Todd A. Mackenzie ◽  
Francisco Lopez-Jimenez ◽  
Stephen J. Bartels
Keyword(s):  
Older Adults ◽  
National Health ◽  
Sarcopenic Obesity ◽  
Functional Impairments ◽  
Health And Nutrition

scholarly journals Mid-adulthood cardiometabolic risk factor profiles of sarcopenic obesity

Obesity ◽  
2016 ◽  
Vol 24 (2) ◽  
pp. 526-534 ◽  
Author(s):  
Jiantao Ma ◽  
Shih-Jen Hwang ◽  
Gearoid M. McMahon ◽  
Gary C. Curhan ◽  
Robert R. Mclean ◽  
...  
Keyword(s):  
Risk Factor ◽  
Cardiometabolic Risk ◽  
Sarcopenic Obesity ◽  
Cardiometabolic Risk Factor

scholarly journals Intranasal Oxytocin Improves Lean Muscle Mass in Older Adults With Sarcopenic Obesity: A Pilot Study

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 133-133
Author(s):  
Jessica Lee ◽  
Sara Espinoza ◽  
Adetutu Odejimi ◽  
Chen-pin Wang ◽  
Vinutha Ganapathy ◽  
...  
Keyword(s):  
Older Adults ◽  
Weight Loss ◽  
Muscle Mass ◽  
Fat Mass ◽  
Lean Mass ◽  
Sarcopenic Obesity ◽  
Whole Body ◽  
Oral Glucose ◽  
Functional Impairments ◽  
Lean Muscle Mass

Abstract Obese older adults often have sarcopenia with increased functional impairments. Unfortunately, conventional weight loss treatments can lead to further muscle mass loss. Increasing evidence from animal studies suggests that the pituitary hormone oxytocin has trophic effects on skeletal muscle cells and can induce weight loss. We piloted a clinical trial testing whether intranasal oxytocin would decrease adiposity without lowering muscle mass in older adults with sarcopenic obesity. Twenty-one older (≥60years), obese (30-43kg/m2), sedentary (<2 strenuous exercises/week) adults with slow gait speed (<1m/sec) were randomized to intra-nasal oxytocin (24IU four times/day) or placebo for 8 weeks. Pre and post body mass index (BMI), 2-hour oral glucose tolerance test (OGTT), hemoglobin A1c (HbA1c), short physical performance battery (SPPB), and whole body lean and fat mass (via dual-energy X-ray absorptiometry) were assessed. Generalized estimation equation method was used to evaluate effects of oxytocin on these continuous measures. At baseline, results were: age 67.5±5.4years, 71% female, BMI 36.0±3.6kg/m2, HbA1c 5.7±0.4%, 2-hr OGTT glucose 140.8±4.1mg/dL, SPPB 9.2±1.9, fat mass 45,429±7,037g, and lean mass was 49,892±10,470g. From baseline to follow-up, total lean mass increased significantly (2,250g) in the oxytocin group (pre- vs. post-treatment difference of -690g in placebo and +1,559g in oxytocin, p<0.01). Oxytocin did not lead to significant changes in other measures. This data suggests that oxytocin leads to significant improvement in whole body lean mass. Future studies in a larger study population will help determine whether older adults with sarcopenic obesity may benefit from intranasal oxytocin to improve lean muscle mass and physical function.

Abstract #517: Neck Circumference as a Cardiometabolic Risk Predictor Among Saudi Subjects

2016 ◽  
Vol 22 ◽  
pp. 125
Author(s):  
Reem Alshenaifi ◽  
Eman Alfadhli ◽  
Hanan Habeeb ◽  
Alaa Sondokji ◽  
Mohammed Makkawi ◽  
...  
Keyword(s):  
Cardiometabolic Risk ◽  
Neck Circumference ◽  
Risk Predictor

Increased monocyte to HDL cholesterol ratio in vitamin B12 deficiency: is it related to cardiometabolic risk?

2020 ◽  
pp. 1-8
Author(s):  
Sanem Kayhan ◽  
Nazli Gulsoy Kirnap ◽  
Mercan Tastemur
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Uric Acid ◽  
Vitamin B12 ◽  
Cardiometabolic Risk ◽  
Vitamin B12 Deficiency ◽  
Left Ventricular ◽  
Cardiometabolic Risk Factors ◽  
B12 Deficiency ◽  
Deficiency Group

Abstract. Vitamin B12 deficiency may have indirect cardiovascular effects in addition to hematological and neuropsychiatric symptoms. It was shown that the monocyte count-to-high density lipoprotein cholesterol (HDL-C) ratio (MHR) is a novel cardiovascular marker. In this study, the aim was to evaluate whether MHR was high in patients with vitamin B12 deficiency and its relationship with cardiometabolic risk factors. The study included 128 patients diagnosed with vitamin B12 deficiency and 93 healthy controls. Patients with vitamin B12 deficiency had significantly higher systolic blood pressure (SBP), diastolic blood pressure (DBP), MHR, C-reactive protein (CRP) and uric acid levels compared with the controls (median 139 vs 115 mmHg, p < 0.001; 80 vs 70 mmHg, p < 0.001; 14.2 vs 9.5, p < 0.001; 10.2 vs 4 mg/dl p < 0.001; 6.68 vs 4.8 mg/dl, p < 0.001 respectively). The prevalence of left ventricular hypertrophy was higher in vitamin B12 deficiency group (43.8%) than the control group (8.6%) (p < 0.001). In vitamin B12 deficiency group, a positive correlation was detected between MHR and SBP, CRP and uric acid (p < 0.001 r:0.34, p < 0.001 r:0.30, p < 0.001 r:0.5, respectively) and a significant negative correlation was detected between MHR and T-CHOL, LDL, HDL and B12 (p < 0.001 r: −0.39, p < 0.001 r: −0.34, p < 0.001 r: −0.57, p < 0.04 r: −0.17, respectively). MHR was high in vitamin B12 deficiency group, and correlated with the cardiometabolic risk factors in this group, which were SBP, CRP, uric acid and HDL. In conclusion, MRH, which can be easily calculated in clinical practice, can be a useful marker to assess cardiovascular risk in patients with vitamin B12 deficiency.

Effectiveness of a Multidisciplinary Lifestyle Intervention to Reduce Obesity among Children and Adolescents

2020 ◽  
Vol 35 (2) ◽  
pp. 111-118
Author(s):  
Md Rizwanul Ahsan ◽  
Sabrina Makbul ◽  
Probir Kumar Sarkar
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Children And Adolescents ◽  
Physical Performance ◽  
Cardiometabolic Risk ◽  
Dietary Habits ◽  
Obese Children ◽  
Height Ratio ◽  
Waist To Height Ratio ◽  
Family Based

Background: Now a days unhealthy lifestyle primarily responsible for the dramatic increase obesity among children and adolescents. Objective: The purpose of the study is to see the effects of a multidisciplinary lifestyle intervention to reduce obese children and adolescents. The main outcome was cardiometabolic risk based on the waist-to-height ratio (WHTR) measurement. Secondary outcomes were (1) changes in body composition; (2) adherence to a Mediterranean diet; and (3) physical performance. Methods: The study involved 64 overweight/obese children or adolescents conducted at Dhaka Shishu Hospital from October 2017 to September 2018. The intervention was multidisciplinary including nutrition, exercise, and psychological aspects based on a family-based approach; it was delivered for six months for children and three months for adolescents. Before and after the intervention, several anthropometric measures height, body weight, body mass index (BMI), waist circumference, and body composition, cardiometabolic risk index waist-to-height ratio (WHTR), and dietary habits of the participants and their families were evaluated. In addition, a set of functional motor fitness tests was performed to evaluate physical performance measures. Results: After the intervention both children and adolescents showed a significant reduction in body weight, BMI, waist circumference, fat mass, and WHTR index and an improvement of fat-free mass, adherence to the Mediterranean diet, and physical fitness performance. Conclusion: A short term family-based multidisciplinary approach is effective in ameliorating the health status, dietary habits, and physical performance in children and adolescents. DS (Child) H J 2019; 35(2) : 111-118

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