Evaluation of disease-mediated therapeutic protein-drug interactions between an anti-interleukin-6 monoclonal antibody (sirukumab) and cytochrome P450 activities in a phase 1 study in patients with rheumatoid arthritis using a cocktail approach

2015 ◽  
Vol 55 (12) ◽  
pp. 1386-1394 ◽  
Author(s):  
Yanli Zhuang ◽  
Dick E. de Vries ◽  
Zhenhua Xu ◽  
Stanley J. Marciniak ◽  
Dion Chen ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Monoclonal Antibody ◽  
Cytochrome P450 ◽  
Drug Interactions ◽  
Interleukin 6 ◽  
Phase 1 ◽  
Therapeutic Protein ◽  
Protein Drug ◽  
Phase 1 Study ◽  
Cocktail Approach

scholarly journals Phase 1 study of MEDI0562, a humanized OX40 agonist monoclonal antibody (mAb), in adult patients (pts) with advanced solid tumors

2016 ◽  
Vol 27 ◽  
pp. vi361 ◽  
Author(s):  
B.S. Glisson ◽  
R. Leidner ◽  
R.L. Ferris ◽  
J. Powderly ◽  
N. Rizvi ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Solid Tumors ◽  
Phase 1 ◽  
Adult Patients ◽  
Advanced Solid Tumors ◽  
Phase 1 Study

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2014 ◽  
Vol 25 ◽  
pp. v70 ◽  
Author(s):  
Hiroshi Nokihara ◽  
Noboru Yamamoto ◽  
Yosuke Tamura ◽  
Yuko Tanabe ◽  
Kazunori Honda ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Solid Tumors ◽  
Phase 1 ◽  
Japanese Patients ◽  
Advanced Solid Tumors ◽  
Phase 1 Study
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