Protective effect of dimethyl itaconate against fibroblast–myofibroblast differentiation during pulmonary fibrosis by inhibiting TXNIP

2021 ◽  
Author(s):  
Yong‐Yue Han ◽  
Xuan Gu ◽  
Chong‐Yang Yang ◽  
Hui‐Min Ji ◽  
Yue‐Jiao Lan ◽  
...  
Keyword(s):  
Pulmonary Fibrosis ◽  
Protective Effect ◽  
Myofibroblast Differentiation ◽  
Dimethyl Itaconate

scholarly journals Butyrate Prevents TGF-β1-Induced Alveolar Myofibroblast Differentiation and Modulates Energy Metabolism

Metabolites ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 258
Author(s):  
Hyo Yeong Lee ◽  
Somi Nam ◽  
Mi Jeong Kim ◽  
Su Jung Kim ◽  
Sung Hoon Back ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Pulmonary Fibrosis ◽  
Transforming Growth Factor ◽  
Mitochondrial Dynamics ◽  
Tca Cycle ◽  
Lung Fibroblasts ◽  
Myofibroblast Differentiation ◽  
Pulmonary Fibroblasts ◽  
Matrix Deposition ◽  
Tgf Β1

Idiopathic pulmonary fibrosis (IPF) is a serious lung disease characterized by excessive collagen matrix deposition and extracellular remodeling. Signaling pathways mediated by fibrotic cytokine transforming growth factor β1 (TGF-β1) make important contributions to pulmonary fibrosis, but it remains unclear how TGF-β1 alters metabolism and modulates the activation and differentiation of pulmonary fibroblasts. We found that TGF-β1 lowers NADH and NADH/NAD levels, possibly due to changes in the TCA cycle, resulting in reductions in the ATP level and oxidative phosphorylation in pulmonary fibroblasts. In addition, we showed that butyrate (C4), a short chain fatty acid (SCFA), exhibits potent antifibrotic activity by inhibiting expression of fibrosis markers. Butyrate treatment inhibited mitochondrial elongation in TGF-β1-treated lung fibroblasts and increased the mitochondrial membrane potential (MMP). Consistent with the mitochondrial observations, butyrate significantly increased ADP, ATP, NADH, and NADH/NAD levels in TGF-β1-treated pulmonary fibroblasts. Collectively, our findings indicate that TGF-β1 induces changes in mitochondrial dynamics and energy metabolism during myofibroblast differentiation, and that these changes can be modulated by butyrate, which enhances mitochondrial function.

scholarly journals Role of Cation Channel TRPV4 in Mechanosensing, Myofibroblast Differentiation, and Pulmonary Fibrosis

2015 ◽  
Vol 12 (Supplement 1) ◽  
pp. S74-S75
Author(s):  
Shaik O. Rahaman ◽  
Lisa M. Grove ◽  
Brian D. Southern ◽  
Rachel G. Scheraga ◽  
Susamma Abraham ◽  
...  
Keyword(s):  
Pulmonary Fibrosis ◽  
Cation Channel ◽  
Myofibroblast Differentiation

Protective effect of adiponectin on paraquat-induced pulmonary fibrosis in mice

2015 ◽  
Vol 11 (2) ◽  
pp. 247-255 ◽  
Author(s):  
Rong Yao ◽  
Yarong He ◽  
Zhi Zeng ◽  
Zongan Liang ◽  
Yu Cao
Keyword(s):  
Pulmonary Fibrosis ◽  
Protective Effect
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