scholarly journals Polyporus Polysaccharide Ameliorates Bleomycin-Induced Pulmonary Fibrosis by Suppressing Myofibroblast Differentiation via TGF-β/Smad2/3 Pathway

2020 ◽  
Vol 11 ◽  
Author(s):  
Jintao Jiang ◽  
Fang Wang ◽  
Aishu Luo ◽  
Shiyu Lin ◽  
Xiaoke Feng ◽  
...  
Keyword(s):  
Pulmonary Fibrosis ◽  
Myofibroblast Differentiation

scholarly journals Butyrate Prevents TGF-β1-Induced Alveolar Myofibroblast Differentiation and Modulates Energy Metabolism

Metabolites ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 258
Author(s):  
Hyo Yeong Lee ◽  
Somi Nam ◽  
Mi Jeong Kim ◽  
Su Jung Kim ◽  
Sung Hoon Back ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Pulmonary Fibrosis ◽  
Transforming Growth Factor ◽  
Mitochondrial Dynamics ◽  
Tca Cycle ◽  
Lung Fibroblasts ◽  
Myofibroblast Differentiation ◽  
Pulmonary Fibroblasts ◽  
Matrix Deposition ◽  
Tgf Β1

Idiopathic pulmonary fibrosis (IPF) is a serious lung disease characterized by excessive collagen matrix deposition and extracellular remodeling. Signaling pathways mediated by fibrotic cytokine transforming growth factor β1 (TGF-β1) make important contributions to pulmonary fibrosis, but it remains unclear how TGF-β1 alters metabolism and modulates the activation and differentiation of pulmonary fibroblasts. We found that TGF-β1 lowers NADH and NADH/NAD levels, possibly due to changes in the TCA cycle, resulting in reductions in the ATP level and oxidative phosphorylation in pulmonary fibroblasts. In addition, we showed that butyrate (C4), a short chain fatty acid (SCFA), exhibits potent antifibrotic activity by inhibiting expression of fibrosis markers. Butyrate treatment inhibited mitochondrial elongation in TGF-β1-treated lung fibroblasts and increased the mitochondrial membrane potential (MMP). Consistent with the mitochondrial observations, butyrate significantly increased ADP, ATP, NADH, and NADH/NAD levels in TGF-β1-treated pulmonary fibroblasts. Collectively, our findings indicate that TGF-β1 induces changes in mitochondrial dynamics and energy metabolism during myofibroblast differentiation, and that these changes can be modulated by butyrate, which enhances mitochondrial function.

scholarly journals Role of Cation Channel TRPV4 in Mechanosensing, Myofibroblast Differentiation, and Pulmonary Fibrosis

2015 ◽  
Vol 12 (Supplement 1) ◽  
pp. S74-S75
Author(s):  
Shaik O. Rahaman ◽  
Lisa M. Grove ◽  
Brian D. Southern ◽  
Rachel G. Scheraga ◽  
Susamma Abraham ◽  
...  
Keyword(s):  
Pulmonary Fibrosis ◽  
Cation Channel ◽  
Myofibroblast Differentiation

TNF-α-induced NF-κB activation promotes myofibroblast differentiation of LR-MSCs and exacerbates bleomycin-induced pulmonary fibrosis

2017 ◽  
Vol 233 (3) ◽  
pp. 2409-2419 ◽  
Author(s):  
Jiwei Hou ◽  
Tan Ma ◽  
Honghui Cao ◽  
Yabing Chen ◽  
Cong Wang ◽  
...  
Keyword(s):  
Pulmonary Fibrosis ◽  
Myofibroblast Differentiation ◽  
Tnf Α
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