scholarly journals Human placenta‐derived mesenchymal stem cells induce trophoblast invasion via dynamic effects on mitochondrial function

2021 ◽  
Author(s):  
Jin Seok ◽  
Sujin Jun ◽  
Jinki Cho ◽  
Sohea Park ◽  
Jung Ok Lee ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Mitochondrial Function ◽  
Human Placenta ◽  
Trophoblast Invasion ◽  
Dynamic Effects

scholarly journals Mitochondrial Dynamics in Placenta-Derived Mesenchymal Stem Cells Regulate the Invasion Activity of Trophoblast

2020 ◽  
Vol 21 (22) ◽  
pp. 8599 ◽  
Author(s):  
Jin Seok ◽  
Sujin Jun ◽  
Jung Ok Lee ◽  
Gi Jin Kim
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Mitochondrial Function ◽  
Mitochondrial Dynamics ◽  
Atp Synthesis ◽  
Trophoblast Invasion ◽  
Ubiquitin Protein Ligase ◽  
Extracellular Flux ◽  
Cellular Events ◽  
Cancerous Cells

Mitochondrial dynamics are involved in many cellular events, including the proliferation, differentiation, and invasion/migration of normal as well as cancerous cells. Human placenta-derived mesenchymal stem cells (PD-MSCs) were known to regulate the invasion activity of trophoblasts. However, the effects of PD-MSCs on mitochondrial function in trophoblasts are still insufficiently understood. Therefore, the objectives of this study are to analyze the factors related to mitochondrial function and investigate the correlation between trophoblast invasion and mitophagy via PD-MSC cocultivation. We assess invasion ability and mitochondrial function in invasive trophoblasts according to PD-MSC cocultivation by quantitative reverse transcription polymerase chain reaction (qRT-PCR) and extracellular flux (XF) assay. Under PD-MSCs co-cultivation, invasion activity of a trophoblast is increased via activation of the Rho signaling pathway as well as Matrix metalloproteinases (MMPs). Additionally, the expression of mitochondrial function (e.g., reactive oxygen species (ROS), calcium, and adenosine triphosphate (ATP) synthesis) in trophoblasts are increased via PD-MSCs co-cultivation. Finally, PD-MSCs regulate mitochondrial autophagy factors in invasive trophoblasts via regulating the balance between PTEN-induced putative kinase 1 (PINK1) and parkin RBR E3 ubiquitin protein ligase (PARKIN) expression. Taken together, these results demonstrate that PD-MSCs enhance the invasion ability of trophoblasts via altering mitochondrial dynamics. These results support the fundamental mechanism of trophoblast invasion via mitochondrial function and provide a new stem cell therapy for infertility.

scholarly journals Osteogenic differentiation of human placenta-derived mesenchymal stem cells (PMSCs) on electrospun nanofiber meshes

2012 ◽  
Vol 64 (6) ◽  
pp. 701-710 ◽  
Author(s):  
Dongmei Zhang ◽  
Aiping Tong ◽  
Liangxue Zhou ◽  
Fang Fang ◽  
Gang Guo
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Osteogenic Differentiation ◽  
Human Placenta ◽  
Electrospun Nanofiber

Human placenta‐derived mesenchymal stem cells inhibit apoptosis of granulosa cells induced by IRE1α pathway in autoimmune POF mice

2019 ◽  
Vol 43 (8) ◽  
pp. 899-909 ◽  
Author(s):  
Hongxing Li ◽  
Wei Zhao ◽  
Li Wang ◽  
Qianqian Luo ◽  
Na Yin ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Granulosa Cells ◽  
Human Placenta
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