KIF15 promotes the evolution of gastric cancer cells through inhibition of reactive oxygen species‐mediated apoptosis

2020 ◽  
Vol 235 (12) ◽  
pp. 9388-9398 ◽  
Author(s):  
Jinqiu Tao ◽  
Guangli Sun ◽  
Qing Li ◽  
Xiaofei Zhi ◽  
Zheng Li ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Reactive Oxygen Species ◽  
Cancer Cells ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Gastric Cancer Cells

scholarly journals Mild hyperthermia enhances sensitivity of gastric cancer cells to chemotherapy through reactive oxygen species–induced autophagic death

Tumor Biology ◽  
2017 ◽  
Vol 39 (6) ◽  
pp. 101042831771195 ◽  
Author(s):  
Ming-Chen Ba ◽  
Hui Long ◽  
Shu-Zhong Cui ◽  
Yuan-Feng Gong ◽  
Zhao-Fei Yan ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Reactive Oxygen Species ◽  
Cancer Cells ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Gastric Cancer Cells ◽  
Mild Hyperthermia

Shikonin time-dependently induced necrosis or apoptosis in gastric cancer cells via generation of reactive oxygen species

2014 ◽  
Vol 211 ◽  
pp. 44-53 ◽  
Author(s):  
Mu-Jang Lee ◽  
Shao-Hsuan Kao ◽  
Jing-En Hunag ◽  
Gwo-Tarng Sheu ◽  
Chi-Wei Yeh ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Reactive Oxygen Species ◽  
Cancer Cells ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Gastric Cancer Cells

scholarly journals Autophagic death induced by thermo-chemotherapy in gastric cancer cells results from the reactive oxygen species pathway

2016 ◽  
Vol 14 (2) ◽  
pp. 1210-1218 ◽  
Author(s):  
Yinbing Wu ◽  
Mingxin Pan ◽  
Shuzhong Cui ◽  
Mingchen Ba ◽  
Zulong Chen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Reactive Oxygen Species ◽  
Cancer Cells ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Gastric Cancer Cells

scholarly journals Positive feedback between ROS and cis-axis of PIASxα/p38α-SUMOylation/MK2 facilitates gastric cancer metastasis

2021 ◽  
Vol 12 (11) ◽  
Author(s):  
Qian Wang ◽  
Ci Xu ◽  
Qiang Fan ◽  
Haihua Yuan ◽  
Xin Zhang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gastric Cancer ◽  
Reactive Oxygen Species ◽  
Stress Response ◽  
Cancer Cells ◽  
Regulatory Mechanism ◽  
Reactive Oxygen ◽  
Oxidative Stress Response ◽  
Oxygen Species ◽  
Gastric Cancer Cells

AbstractMAPK/p38 is an important mammalian signaling cascade that responds to a variety of intracellular or extracellular stimuli, such as reactive oxygen species (ROS), and participates in numerous physiological and pathological processes. However, the biological function of p38 in different tumors, and even at different stages of the same tumor, remains elusive. To further understand the regulatory mechanism of p38 and oxidative stress in the occurrence and development of gastric cancer, we report SUMOylation as a novel post-translational modification occurring on lysine 152 of MAPK14/p38α through immunoprecipitation and series of pull-down assays in vitro and in vivo. Importantly, we determine that p38α-SUMOylation functions as an authentic sensor and accelerator of reactive oxygen species generation via interaction with and activation of MK2 in the nucleus, and the ROS accumulation, in turn, promotes the SUMOylation of p38α by stabilizing the PIASxα protein. This precise regulatory mechanism is exploited by gastric cancer cells to create an internal environment for survival and, ultimately, metastasis. This study reveals novel insights into p38α-SUMOylation and its association with the intracellular oxidative stress response, which is closely related to the processes of gastric cancer. Furthermore, the PIASxα/p38α-SUMOylation/MK2 cis-axis may serve as a desirable therapeutic target in gastric cancer as targeting PIASxα, MK2, or a specific peptide region of p38α may reconcile the aberrant oxidative stress response in gastric cancer cells.

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