PRR34‐AS1 overexpression promotes protection of propofol pretreatment against ischemia/reperfusion injury in a mouse model after total knee arthroplasty via blockade of the JAK1‐dependent JAK‐STAT signaling pathway

2019 ◽  
Vol 235 (3) ◽  
pp. 2545-2556 ◽  
Author(s):  
Hua Fang ◽  
Fang‐Xiang Zhang ◽  
Hua‐Feng Li ◽  
Miao Yang ◽  
Ren Liao ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Mouse Model ◽  
Reperfusion Injury ◽  
Signaling Pathway ◽  
Knee Arthroplasty ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Stat Signaling ◽  
Total Knee

scholarly journals Impact of Anesthetic Agents on Endothelial Glycocalyx Injury during Total Knee Arthroplasty: Desflurane- vs. Propofol-Based Anesthesia—A Prospective Randomized Controlled Trial

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Chung-Sik Oh ◽  
Ji Min Choi ◽  
Eun Hi Park ◽  
Liyun Piao ◽  
Hyun-Jun Park ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Reperfusion Injury ◽  
Knee Arthroplasty ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Endothelial Glycocalyx ◽  
Arterial Line ◽  
Laboratory Values ◽  
Total Knee ◽  
Tourniquet Deflation

Background. Ischemia-reperfusion injury and inflammation after tourniquet deflation in total knee arthroplasty are known to be associated with endothelial glycocalyx (EG) injury. This study is aimed at comparing EG injury between desflurane- and propofol-based anesthesia in patients undergoing total knee arthroplasty. Materials and Methods. Patients were allocated to the desflurane group or propofol group. The opioid remifentanil was administered intraoperatively in both groups. Blood samples were obtained from the arterial line preoperatively, immediately before and 5 min after tourniquet deflation, and at 1, 6, and 24 h, postoperatively. Serum syndecan-1, cytokines (interleukin-1β, 6, 10, and tumour necrosis factor-α), and other laboratory values were investigated. Results. Eighty patients were included in the final analysis. The change in syndecan-1 did not significantly differ between the desflurane and propofol groups (peak median level of syndecan-1; 754.5 pg/ml vs. 780.3 pg/ml, respectively, P = 0.512 ). Laboratory values (serum cytokines, creatinine phosphokinase, lactate dehydrogenase, and lactate levels) were also similar between the two groups. Pulmonary oxygenation was briefly improved after tourniquet deflation in the desflurane group but was similar between the two groups begging at 1 h, postoperatively. Conclusions. The effect of desflurane was not superior to that of propofol in protecting the EG from ischemia-reperfusion injury during total knee arthroplasty. This trial is registered with Trial Registry Number NCT02756715 (http://clinicaltrials.gov).

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