scholarly journals Systematic analysis of differentially methylated expressed genes and site‐specific methylation as potential prognostic markers in head and neck cancer

2019 ◽  
Vol 234 (12) ◽  
pp. 22687-22702 ◽  
Author(s):  
Guohui Bai ◽  
Jukun Song ◽  
Yiwen Yuan ◽  
Zhu Chen ◽  
Yuan Tian ◽  
...  
2016 ◽  
Vol 56 (3) ◽  
pp. 1107-1116 ◽  
Author(s):  
Kiyoshi Misawa ◽  
Daiki Mochizuki ◽  
Shiori Endo ◽  
Masato Mima ◽  
Yuki Misawa ◽  
...  

Oncotarget ◽  
2017 ◽  
Vol 8 (44) ◽  
pp. 76318-76328 ◽  
Author(s):  
Kiyoshi Misawa ◽  
Atsushi Imai ◽  
Daiki Mochizuki ◽  
Yuki Misawa ◽  
Shiori Endo ◽  
...  

2004 ◽  
Vol 114 (5) ◽  
pp. 806-816 ◽  
Author(s):  
André Lopes Carvalho ◽  
Inês Nobuko Nishimoto ◽  
Joseph A. Califano ◽  
Luiz Paulo Kowalski

Cancers ◽  
2018 ◽  
Vol 10 (1) ◽  
pp. 27 ◽  
Author(s):  
Kiyoshi Misawa ◽  
Daiki Mochizuki ◽  
Atsushi Imai ◽  
Masato Mima ◽  
Yuki Misawa ◽  
...  

Cancers ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 2387
Author(s):  
Anna Maria Wirsing ◽  
Inger-Heidi Bjerkli ◽  
Sonja Eriksson Steigen ◽  
Oddveig Rikardsen ◽  
Synnøve Norvoll Magnussen ◽  
...  

The Pathology Atlas is an open-access database that reports the prognostic value of protein-coding transcripts in 17 cancers, including head and neck cancer. However, cancers of the various head and neck anatomical sites are specific biological entities. Thus, the aim of the present study was to validate promising prognostic markers for head and neck cancer reported in the Pathology Atlas in oral tongue squamous cell carcinoma (OTSCC). We selected three promising markers from the Pathology Atlas (CALML5, CD59, LIMA1), and analyzed their prognostic value in a Norwegian OTSCC cohort comprising 121 patients. We correlated target protein and mRNA expression in formalin-fixed, paraffin-embedded cancer tissue to five-year disease-specific survival (DSS) in univariate and multivariate analyses. Protein expression of CALML5 and LIMA1 were significantly associated with five-year DSS in the OTSCC cohort in univariate analyses (p = 0.016 and p = 0.043, respectively). In multivariate analyses, lymph node metastases, tumor differentiation, and CALML5 were independent prognosticators. The prognostic role of the other selected markers for head and neck cancer patients identified through unbiased approaches could not be validated in our OTSCC cohort. This underlines the need for subsite-specific analyses for head and neck cancer.


PLoS ONE ◽  
2016 ◽  
Vol 11 (1) ◽  
pp. e0147409 ◽  
Author(s):  
Ram Bhupal Reddy ◽  
Anupama Rajan Bhat ◽  
Bonney Lee James ◽  
Sindhu Valiyaveedan Govindan ◽  
Rohit Mathew ◽  
...  

2010 ◽  
Vol 16 (3) ◽  
pp. 1008-1015 ◽  
Author(s):  
F. Meyer ◽  
E. Samson ◽  
P. Douville ◽  
T. Duchesne ◽  
G. Liu ◽  
...  

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