scholarly journals Analyzing tyrosine kinase activity in head and neck cancer by functional kinomics: Identification of hyperactivated Src‐family kinases as prognostic markers and potential targets

2021 ◽  
Author(s):  
Lara Bußmann ◽  
Konstantin Hoffer ◽  
Clara Marie von Bargen ◽  
Conrad Droste ◽  
Tobias Lange ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Tyrosine Kinase ◽  
Head And Neck ◽  
Neck Cancer ◽  
Kinase Activity ◽  
Prognostic Markers ◽  
Src Family Kinases ◽  
Tyrosine Kinase Activity

Spleen tyrosine kinase expression is correlated with human papillomavirus in head and neck cancer

Oral Oncology ◽  
2020 ◽  
Vol 101 ◽  
pp. 104529 ◽  
Author(s):  
Morgan Black ◽  
Farhad Ghasemi ◽  
Ren X. Sun ◽  
William Stecho ◽  
Alessandro Datti ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Human Papillomavirus ◽  
Tyrosine Kinase ◽  
Head And Neck ◽  
Neck Cancer ◽  
Spleen Tyrosine Kinase ◽  
Kinase Expression

S115 The Receptor Tyrosine Kinase c-MET Is Mutated in Head and Neck Cancer and Is a Promising Novel Target

2006 ◽  
Vol 132 (8) ◽  
pp. 864
Author(s):  
T. Y. Seiwert ◽  
A. J. Klein-Szanto ◽  
R. Jagadeeswaran ◽  
M. Tretiakova ◽  
L. Martin ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Tyrosine Kinase ◽  
Head And Neck ◽  
Neck Cancer ◽  
Receptor Tyrosine Kinase ◽  
Kinase C ◽  
Novel Target

scholarly journals Implication of the Receptor Tyrosine Kinase AXL in Head and Neck Cancer Progression

2016 ◽  
Vol 18 (1) ◽  
pp. 7 ◽  
Author(s):  
Anne von Mässenhausen ◽  
Johannes Brägelmann ◽  
Hannah Billig ◽  
Britta Thewes ◽  
Angela Queisser ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Tyrosine Kinase ◽  
Head And Neck ◽  
Cancer Progression ◽  
Neck Cancer ◽  
Receptor Tyrosine Kinase

scholarly journals Melanoma-associated antigen expression and the efficacy of tyrosine kinase inhibitors in head and neck cancer

2015 ◽  
Vol 10 (2) ◽  
pp. 1211-1217 ◽  
Author(s):  
STEFAN HARTMANN ◽  
ROMAN C. BRANDS ◽  
NORA KÜCHLER ◽  
ANDREAS FUCHS ◽  
CHRISTIAN LINZ ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Tyrosine Kinase ◽  
Head And Neck ◽  
Tyrosine Kinase Inhibitors ◽  
Neck Cancer ◽  
Kinase Inhibitors ◽  
Antigen Expression

scholarly journals Validation of Selected Head and Neck Cancer Prognostic Markers from the Pathology Atlas in an Oral Tongue Cancer Cohort

Cancers ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 2387
Author(s):  
Anna Maria Wirsing ◽  
Inger-Heidi Bjerkli ◽  
Sonja Eriksson Steigen ◽  
Oddveig Rikardsen ◽  
Synnøve Norvoll Magnussen ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Prognostic Value ◽  
Prognostic Markers ◽  
Multivariate Analyses ◽  
Tongue Cancer ◽  
Cancer Tissue ◽  
Oral Tongue ◽  
Protein Coding

The Pathology Atlas is an open-access database that reports the prognostic value of protein-coding transcripts in 17 cancers, including head and neck cancer. However, cancers of the various head and neck anatomical sites are specific biological entities. Thus, the aim of the present study was to validate promising prognostic markers for head and neck cancer reported in the Pathology Atlas in oral tongue squamous cell carcinoma (OTSCC). We selected three promising markers from the Pathology Atlas (CALML5, CD59, LIMA1), and analyzed their prognostic value in a Norwegian OTSCC cohort comprising 121 patients. We correlated target protein and mRNA expression in formalin-fixed, paraffin-embedded cancer tissue to five-year disease-specific survival (DSS) in univariate and multivariate analyses. Protein expression of CALML5 and LIMA1 were significantly associated with five-year DSS in the OTSCC cohort in univariate analyses (p = 0.016 and p = 0.043, respectively). In multivariate analyses, lymph node metastases, tumor differentiation, and CALML5 were independent prognosticators. The prognostic role of the other selected markers for head and neck cancer patients identified through unbiased approaches could not be validated in our OTSCC cohort. This underlines the need for subsite-specific analyses for head and neck cancer.

scholarly journals Meta-Analyses of Microarray Datasets Identifies ANO1 and FADD as Prognostic Markers of Head and Neck Cancer

PLoS ONE ◽  
2016 ◽  
Vol 11 (1) ◽  
pp. e0147409 ◽  
Author(s):  
Ram Bhupal Reddy ◽  
Anupama Rajan Bhat ◽  
Bonney Lee James ◽  
Sindhu Valiyaveedan Govindan ◽  
Rohit Mathew ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Prognostic Markers ◽  
Meta Analyses ◽  
Microarray Datasets

scholarly journals Serum Prognostic Markers in Head and Neck Cancer

2010 ◽  
Vol 16 (3) ◽  
pp. 1008-1015 ◽  
Author(s):  
F. Meyer ◽  
E. Samson ◽  
P. Douville ◽  
T. Duchesne ◽  
G. Liu ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Prognostic Markers
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