Analysis of pro‐ and anti‐inflammatory cytokine gene variants and serum cytokine levels as prognostic markers in breast cancer

2018 ◽  
Vol 233 (12) ◽  
pp. 9716-9723 ◽  
Author(s):  
Raman Preet Kaur ◽  
Kanika Vasudeva ◽  
Heena Singla ◽  
Raja Paramjeet Singh Benipal ◽  
Preeti Khetarpal ◽  
...  
Author(s):  
Sergei G. Levin ◽  
Ekaterina V. Pershina ◽  
Nickolay A. Bugaev-Makarovskiy ◽  
Irina Yu. Chernomorets ◽  
Maxim V. Konakov ◽  
...  

Surgery Today ◽  
2013 ◽  
Vol 44 (6) ◽  
pp. 1123-1127 ◽  
Author(s):  
Takashi Mitsui ◽  
Kazuhiko Fukatsu ◽  
Masashi Yanagawa ◽  
Syunsuke Amenomori ◽  
Etsushi Ogawa ◽  
...  

2017 ◽  
Vol 29 (4) ◽  
pp. 747 ◽  
Author(s):  
Reza Salehi ◽  
Marcos G. Colazo ◽  
Mohanathas Gobikrushanth ◽  
Urmila Basu ◽  
Divakar J. Ambrose

Postpartum uterine infections affect ovarian function and delay ovulation in cattle. As dietary fats can affect immune cell function, we investigated the influence of prepartum diets on postpartum uterine inflammatory status (UIS) as assessed 25 ± 1 days postpartum by endometrial cytology (normal: ≤8% polymorphonuclear cells (PMN) vs subclinical endometritis (SCE): >8% PMN) and associations between SCE, pro- and anti-inflammatory cytokine gene expression and ovarian function. During the last 5 weeks of gestation, dairy cows received a diet supplemented with 8% rolled sunflower (n = 10) or canola seed (n = 9) or no oilseed (n = 9). Ovaries were scanned until 35 days postpartum. Prepartum diets did not influence SCE, but a preovulatory-size follicle developed sooner (P ≤ 0.05), the interval to first ovulation was shorter and the proportion of cows ovulating within 35 days postpartum was greater in the sunflower seed group. Although mRNA expression of cytokines was not affected by diet, cows with SCE had higher (P ≤ 0.05) expression of interleukin-1β (IL1B), interleukin-8 (CXCL8), IL10 and tumour necrosis factor-α (TNF) than normal cows. The interval (mean ± s.e.m.) from calving to preovulatory-size follicle was shorter (P ≤ 0.05) in normal (13.2 ± 0.9 days) than SCE cows (18.7 ± 1.4 days). In summary, a prepartum diet supplemented with sunflower seed positively influenced postpartum ovarian function without affecting UIS or pro- and anti-inflammatory cytokine gene expression in endometrial cells.


Burns ◽  
2010 ◽  
Vol 36 (4) ◽  
pp. 483-494 ◽  
Author(s):  
C. Csontos ◽  
V. Foldi ◽  
L. Pálinkas ◽  
L. Bogar ◽  
E. Röth ◽  
...  

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Marjeta Terčelj ◽  
Sanja Stopinšek ◽  
Alojz Ihan ◽  
Barbara Salobir ◽  
Saša Simčič ◽  
...  

Background and Objectives. Sarcoidosis is an inflammatory disease with increased levels of inflammatory cytokines. Previous studies have shown a relation between the degree of granuloma infiltration and serum cytokine levels, except for interleukin- (IL-) 10. The aim of the study was to further investigate the serum levels of IL-10 in patients with sarcoidosis and relate them to fungal exposure in terms of the amount of fungi in the air of their homes andβ-glucan in bronchoalveolar lavage (BAL) fluid.Methods. Patients with sarcoidosis (n=71) and healthy controls (n=27) were enrolled. IL-10 was determined in serum. BAL was performed and the amount ofβ-glucan was measured. Domestic exposure to fungi was determined by measuring airborneβ-N-acetylhexosaminidase (NAHA) in the bedrooms.Results. At high levels of fungal exposure (domestic fungal exposure andβ-glucan in BAL), serum IL-10 values were lower than at low and intermediate exposure levels.Conclusion. The low serum IL-10 values at high fungal exposure suggest that fungal cell wall agents play a role in granuloma formation in sarcoidosis by inhibiting the secretion of the anti-inflammatory cytokine IL-10.


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