Chrysin attenuates progression of ovarian cancer cells by regulating signaling cascades and mitochondrial dysfunction

2017 ◽  
Vol 233 (4) ◽  
pp. 3129-3140 ◽  
Author(s):  
Whasun Lim ◽  
Soomin Ryu ◽  
Fuller W. Bazer ◽  
Sung-Man Kim ◽  
Gwonhwa Song
Keyword(s):  
Ovarian Cancer ◽  
Mitochondrial Dysfunction ◽  
Cancer Cells ◽  
Signaling Cascades ◽  
Ovarian Cancer Cells

Acetogenin Extracted from Annona muricata Prevented the Actions of EGF in PA-1 Ovarian Cancer Cells

2020 ◽  
Vol 27 ◽  
Author(s):  
Loganayaki Periyasamy ◽  
Bharathi Muruganantham ◽  
Malarvizhi Deivasigamani ◽  
Hariprasath Lakshmanan ◽  
Sridhar Muthusami
Keyword(s):  
Ovarian Cancer ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Cancer Cells ◽  
In Silico ◽  
Signaling Cascades ◽  
Ovarian Cancer Cells ◽  
Annona Muricata ◽  
Epidermal Growth

Background: In individuals with ovarian cancer, an increase in the circulating level of the epidermal growth factor (EGF) is readily apparent. Ovarian cancer cells exhibit signaling pathway of the epidermal growth factor (EGFR) and respond to the EGF. Annona Muricata (AM) has been shown to decrease ovarian cell proliferation however, role of AM in regulating EGF actions is not yet to be reported. Objective: In this study, we proposed that the fractionated compound acetogenin can inhibit the activation of EGFRregulated signaling cascades such as MAPK7 / PI3K-Akt / mTOR / STAT upon EGF stimulation. Methods: Ethanolic extract was prepared for the whole AM plant and Thin Layer Chromatography (TLC) was performed to characterize the secondary metabolites and each fraction was assessed using kedde reagent for the presence of acetogenin. The effects of acetogenins were then tested on the survival of PA-1 ovarian cancer cells under basal and EGF stimulated conditions. To delineate the role of acetogenin in EGFR signaling cascades, the in silico docking studies were conducted. Discussion: The vital regulatory role of acetogenin reported in this study indicate significant anticancer activities of acetogenin from AM. The in silico study of the acetogenin function predicted that it binds specifically to Asp837 (phosphoracceptor site) of EGFR, essential for phosphorylation of substrates in the TK domain and RU which promote downstream signaling. Conclusion: This study, proposed that acetogenin isolated from AM effectively inhibited the survival of PA-1 ovarian cancer cells through impaired EGF signaling.

Overview of the signaling pathways involved in metastasis: An intriguing story-tale of the metastatic journey of ovarian cancer cells

2021 ◽  
Vol 67 (3) ◽  
pp. 212-223
Author(s):  
Rukset Attar ◽  
Tahira Panah ◽  
Mirna Azalea Romero ◽  
Ishmuratova Margarita Yulaevna ◽  
Maria Gazouli ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Signaling Pathways ◽  
Intracellular Signaling ◽  
Cancer Metastasis ◽  
Scientific Evidence ◽  
Critical Role ◽  
Signaling Cascades ◽  
Ovarian Cancer Cells ◽  
Term Survival

Wealth of information has revolutionized our understanding related to the genetics and functional genomics of this heterogeneous disease. Keeping in view the heterogeneity of ovarian cancer, long-term survival might be achieved by translation of recently emerging mechanistic insights at the cellular and molecular levels to personalize individual strategies for treatment and to identify biomarkers for early detection. Importantly, the motility and invasive properties of ovarian cancer cells are driven by a repertoire of signaling cascades, many components of which have been experimentally verified as therapeutic targets in preclinical models as well as in clinical trials. Scientific evidence garnered over decades of research has deconvoluted the highly intricate intertwined network of intracellular signaling pathways which played fundamental role in carcinogenesis and metastasis. In this review we have provided a compendium of myriad of signaling cascades which have been documented to play critical role in the progression and metastasis of ovarian cancer. We have partitioned this multi-component review into different sections to individually discuss and summarize the roles of TGF/SMAD, JAK/STAT, Wnt/?-Catenin, NOTCH, SHH/GLI, mTORC1/mTORC2, VEGFR and Hippo/YAP pathways in ovarian cancer metastasis.

Cytotoxic effects of disulfiram and synergism with cisplatin on ovarian cancer cells in vitro

2018 ◽  
Author(s):  
F Guo ◽  
Z Yang ◽  
J Xu ◽  
J Sehouli ◽  
AE Albers ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Ovarian Cancer Cells ◽  
Cytotoxic Effects
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