Sideroxylin (Callistemon lanceolatus ) suppressed cell proliferation and increased apoptosis in ovarian cancer cells accompanied by mitochondrial dysfunction, the generation of reactive oxygen species, and an increase of lipid peroxidation

2018 ◽  
Vol 233 (11) ◽  
pp. 8597-8604 ◽  
Author(s):  
Sunwoo Park ◽  
Whasun Lim ◽  
Wonsik Jeong ◽  
Fuller W. Bazer ◽  
Dongho Lee ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Ovarian Cancer ◽  
Lipid Peroxidation ◽  
Cell Proliferation ◽  
Mitochondrial Dysfunction ◽  
Cancer Cells ◽  
Reactive Oxygen ◽  
Ovarian Cancer Cells ◽  
Oxygen Species

The role of reactive oxygen species in WP 631-induced death of human ovarian cancer cells: A comparison with the effect of doxorubicin

2011 ◽  
Vol 25 (8) ◽  
pp. 1712-1720 ◽  
Author(s):  
Aneta Rogalska ◽  
Arkadiusz Gajek ◽  
Marzena Szwed ◽  
Zofia Jóźwiak ◽  
Agnieszka Marczak
Keyword(s):  
Reactive Oxygen Species ◽  
Ovarian Cancer ◽  
Cancer Cells ◽  
Reactive Oxygen ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Oxygen Species

Nobiletin Triggers Reactive Oxygen Species-Mediated Pyroptosis through Regulating Autophagy in Ovarian Cancer Cells

2020 ◽  
Vol 68 (5) ◽  
pp. 1326-1336 ◽  
Author(s):  
Rongjun Zhang ◽  
Jian Chen ◽  
Lianzhi Mao ◽  
Yajie Guo ◽  
Yuting Hao ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Ovarian Cancer ◽  
Cancer Cells ◽  
Reactive Oxygen ◽  
Ovarian Cancer Cells ◽  
Oxygen Species

Aloperine Induces Apoptosis by a Reactive Oxygen Species Activation Mechanism in Human Ovarian Cancer Cells

2020 ◽  
Vol 27 (9) ◽  
pp. 860-869 ◽  
Author(s):  
Mingning Qiu ◽  
Jie Liu ◽  
Yongxia Su ◽  
Jianjun Liu ◽  
Chenchen Wu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Ovarian Cancer ◽  
Hydrogen Peroxide ◽  
Cell Viability ◽  
Cancer Cells ◽  
Reactive Oxygen ◽  
Activation Mechanism ◽  
Ovarian Cancer Cells ◽  
Ros Generation ◽  
Oxygen Species

Background: Ovarian cancer is the most lethal gynecologic malignancy worldwide with poor prognosis owing to chemotherapy resistance and cancer relapse. Hence, there is an urgent need to develop novel anticancer agents against ovarian cancer. Objective: The aim of this research is to investigate the possible anticancer activity of aloperine, an active ingredient from a traditional Chinese medicine Sophora alopecuroides, and to explore the possible Reactive Oxygen Species (ROS)-related mechanism. Methods: Cell viability, cytotoxicity, apoptosis, ROS generation, and oxidant stress indicators were analyzed. Results: Our results demonstrated that aloperine significantly induced inhibition of cell viability, promoted cytotoxicity and mitochondrial-related apoptosis, and increased ROS generation in ovarian cancer cells. Furthermore, the antioxidant α-lipoic acid reversed apoptosis in aloperinetreated cells. In addition, we identified hydrogen peroxide as the main type of ROS, and the antioxidant catalase suppressed the apoptotic inducing effect of aloperine whereas hydrogen peroxide supplement exacerbated the effect of aloperine in ovarian cancer cells. Conclusion: Taken together, our results indicated that aloperine could exert anti-ovarian cancer cell activity through a reactive oxygen species activation mechanism and suggested aloperine as a potential agent against ovarian cancer.

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