Knockout of ATG5 leads to malignant cell transformation and resistance to Src family kinase inhibitor PP2

2017 ◽  
Vol 233 (1) ◽  
pp. 506-515 ◽  
Author(s):  
Sung-Hee Hwang ◽  
Byeal-I Han ◽  
Michael Lee
Keyword(s):  
Kinase Inhibitor ◽  
Cell Transformation ◽  
Malignant Cell ◽  
Src Family Kinase ◽  
Malignant Cell Transformation

scholarly journals Synthesis and in vitro characterization of the genotoxic, mutagenic and cell-transforming potential of nitrosylated heme

2020 ◽  
Vol 94 (11) ◽  
pp. 3911-3927 ◽  
Author(s):  
Tina Kostka ◽  
Jörg Fohrer ◽  
Claudia Guigas ◽  
Karlis Briviba ◽  
Nina Seiwert ◽  
...  
Keyword(s):  
Cell Transformation ◽  
Malignant Cell ◽  
Red Meat ◽  
Colorectal Carcinogenesis ◽  
In Vivo Studies ◽  
Processed Meat ◽  
Cell Transforming ◽  
Malignant Cell Transformation

Abstract Data from epidemiological studies suggest that consumption of red and processed meat is a factor contributing to colorectal carcinogenesis. Red meat contains high amounts of heme, which in turn can be converted to its nitrosylated form, NO-heme, when adding nitrite-containing curing salt to meat. NO-heme might contribute to colorectal cancer formation by causing gene mutations and could thereby be responsible for the association of (processed) red meat consumption with intestinal cancer. Up to now, neither in vitro nor in vivo studies characterizing the mutagenic and cell transforming potential of NO-heme have been published due to the fact that the pure compound is not readily available. Therefore, in the present study, an already existing synthesis protocol was modified to yield, for the first time, purified NO-heme. Thereafter, newly synthesized NO-heme was chemically characterized and used in various in vitro approaches at dietary concentrations to determine whether it can lead to DNA damage and malignant cell transformation. While NO-heme led to a significant dose-dependent increase in the number of DNA strand breaks in the comet assay and was mutagenic in the HPRT assay, this compound tested negative in the Ames test and failed to induce malignant cell transformation in the BALB/c 3T3 cell transformation assay. Interestingly, the non-nitrosylated heme control showed similar effects, but was additionally able to induce malignant transformation in BALB/c 3T3 murine fibroblasts. Taken together, these results suggest that it is the heme molecule rather than the NO moiety which is involved in driving red meat-associated carcinogenesis.

scholarly journals Involvement of Autophagy in Oncogenic K-Ras-induced Malignant Cell Transformation

2011 ◽  
Vol 286 (15) ◽  
pp. 12924-12932 ◽  
Author(s):  
Min-Jung Kim ◽  
Soo-Jung Woo ◽  
Chang-Hwan Yoon ◽  
Jae-Seong Lee ◽  
Sungkwan An ◽  
...  
Keyword(s):  
Cell Transformation ◽  
Malignant Cell ◽  
Malignant Cell Transformation

scholarly journals Bau, a Splice Form of Neurabin-I that Interacts with the Tumor Suppressor Bin1, Inhibits Malignant Cell Transformation

1999 ◽  
Vol 7 (2) ◽  
pp. 99-110 ◽  
Author(s):  
James Duhadaway ◽  
Felicity Rowe ◽  
Katherine Elliott ◽  
Nien-Chen Mao ◽  
George C. Prendergast
Keyword(s):  
Tumor Suppressor ◽  
Cell Transformation ◽  
Malignant Cell ◽  
Splice Form ◽  
Malignant Cell Transformation

scholarly journals Fluorescent dye monitoring of mitochondrial changes associated with malignant cell transformation.

1987 ◽  
Vol 12 (6) ◽  
pp. 525-537 ◽  
Author(s):  
Tetsuro Horikoshi ◽  
Tohru Yoshioka ◽  
Yosinobu Kubota ◽  
Keiji Yanagisawa
Keyword(s):  
Cell Transformation ◽  
Malignant Cell ◽  
Fluorescent Dye ◽  
Malignant Cell Transformation

MUC1 Story: Great Expectations, Disappointments and the Renaissance

2019 ◽  
Vol 26 (3) ◽  
pp. 554-563 ◽  
Author(s):  
Marina S. Syrkina ◽  
Yegor S. Vassetzky ◽  
Mikhail A. Rubtsov
Keyword(s):  
Cell Transformation ◽  
Therapeutic Potential ◽  
Practical Importance ◽  
Anticancer Therapy ◽  
Malignant Cell ◽  
Great Expectations ◽  
Tumor Dissemination ◽  
History Of ◽  
Malignant Cell Transformation ◽  
Strong Ground

In the course of studying human mucin MUC1, the attitude towards this molecule has been changing time and again. Initially, the list of presumable functions of MUC1 was restricted to protecting and lubricating epithelium. To date, it is assumed to play an important role in cell signaling as well as in all stages of oncogenesis, from malignant cell transformation to tumor dissemination. The story of MUC1 is full of hopes and disappointments. However, the scientific interest to MUC1 has never waned, and the more profoundly it has been investigated, the clearer its hidden potential turned to be disclosed. The therapeutic potential of mucin MUC1 has already been noted by various scientific groups at the early stages of research. Over forty years ago, the first insights into MUC1 functions became a strong ground for considering this molecule as potential target for anticancer therapy. Therefore, this direction of research has always been of particular interest and practical importance. More than 200 papers on MUC1 were published in 2016; the majority of them are dedicated to MUC1-related anticancer diagnostics and therapeutics. Here we review the history of MUC1 studies from the very first attempts to reveal its functions to the ongoing renaissance.

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