Up-Regulation of Transient Receptor Potential Melastatin 6 Channel Expression by Tumor Necrosis Factor-α in the Presence of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor

2017 ◽  
Vol 232 (10) ◽  
pp. 2841-2850 ◽  
Author(s):  
Chisa Furukawa ◽  
Naoko Fujii ◽  
Aya Manabe ◽  
Toshiyuki Matsunaga ◽  
Satoshi Endo ◽  
...  
Keyword(s):  
Transient Receptor Potential ◽  
Kinase Inhibitor ◽  
Growth Factor Receptor ◽  
Receptor Potential ◽  
Transient Receptor Potential Melastatin ◽  
Channel Expression ◽  
Epidermal Growth ◽  
Transient Receptor ◽  
Factor Α ◽  
Necrosis Factor

Magnesium in Man: Implications for Health and Disease

2015 ◽  
Vol 95 (1) ◽  
pp. 1-46 ◽  
Author(s):  
Jeroen H. F. de Baaij ◽  
Joost G. J. Hoenderop ◽  
René J. M. Bindels
Keyword(s):  
Transient Receptor Potential ◽  
Growth Factor Receptor ◽  
Physiological Role ◽  
Calcineurin Inhibitors ◽  
Receptor Potential ◽  
Enzymatic Reactions ◽  
Comprehensive Overview ◽  
Transient Receptor Potential Melastatin ◽  
Health And Disease ◽  
Transient Receptor

Magnesium (Mg2+) is an essential ion to the human body, playing an instrumental role in supporting and sustaining health and life. As the second most abundant intracellular cation after potassium, it is involved in over 600 enzymatic reactions including energy metabolism and protein synthesis. Although Mg2+availability has been proven to be disturbed during several clinical situations, serum Mg2+values are not generally determined in patients. This review aims to provide an overview of the function of Mg2+in human health and disease. In short, Mg2+plays an important physiological role particularly in the brain, heart, and skeletal muscles. Moreover, Mg2+supplementation has been shown to be beneficial in treatment of, among others, preeclampsia, migraine, depression, coronary artery disease, and asthma. Over the last decade, several hereditary forms of hypomagnesemia have been deciphered, including mutations in transient receptor potential melastatin type 6 (TRPM6), claudin 16, and cyclin M2 (CNNM2). Recently, mutations in Mg2+transporter 1 (MagT1) were linked to T-cell deficiency underlining the important role of Mg2+in cell viability. Moreover, hypomagnesemia can be the consequence of the use of certain types of drugs, such as diuretics, epidermal growth factor receptor inhibitors, calcineurin inhibitors, and proton pump inhibitors. This review provides an extensive and comprehensive overview of Mg2+research over the last few decades, focusing on the regulation of Mg2+homeostasis in the intestine, kidney, and bone and disturbances which may result in hypomagnesemia.

scholarly journals Rapidly inducible changes in phosphatidylinositol 4,5-bisphosphate levels influence multiple regulatory functions of the lipid in intact living cells

2006 ◽  
Vol 175 (3) ◽  
pp. 377-382 ◽  
Author(s):  
Peter Varnai ◽  
Baskaran Thyagarajan ◽  
Tibor Rohacs ◽  
Tamas Balla
Keyword(s):  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Fusion Construct ◽  
Type Iv ◽  
Transient Receptor Potential Melastatin ◽  
Rapid Changes ◽  
Epidermal Growth ◽  
Transient Receptor ◽  
Regulatory Functions ◽  
Transferrin Uptake

Rapamycin (rapa)-induced heterodimerization of the FRB domain of the mammalian target of rapa and FKBP12 was used to translocate a phosphoinositide 5-phosphatase (5-ptase) enzyme to the plasma membrane (PM) to evoke rapid changes in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) levels. Rapa-induced PM recruitment of a truncated type IV 5-ptase containing only the 5-ptase domain fused to FKBP12 rapidly decreased PM PtdIns(4,5)P2 as monitored by the PLCδ1PH-GFP fusion construct. This decrease was paralleled by rapid termination of the ATP-induced Ca2+ signal and the prompt inactivation of menthol-activated transient receptor potential melastatin 8 (TRPM8) channels. Depletion of PM PtdIns(4,5)P2 was associated with a complete blockade of transferrin uptake and inhibition of epidermal growth factor internalization. None of these changes were observed upon rapa-induced translocation of an mRFP-FKBP12 fusion protein that was used as a control. These data demonstrate that rapid inducible depletion of PM PtdIns(4,5)P2 is a powerful tool to study the multiple regulatory roles of this phospholipid and to study differential sensitivities of various processes to PtdIns(4,5)P2 depletion.

The TRPM7 Channel in the Nervous and Cardiovascular Systems

2020 ◽  
Vol 21 (10) ◽  
pp. 985-992 ◽  
Author(s):  
Koichi Inoue ◽  
Zhi-Gang Xiong ◽  
Takatoshi Ueki
Keyword(s):  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Kinase Domain ◽  
Cellular Functions ◽  
Transient Receptor Potential Melastatin ◽  
Cation Permeability ◽  
Cardiovascular Systems ◽  
Transient Receptor ◽  
Excitatory Responses ◽  
Dual Operations

: Transient receptor potential melastatin 7 (TRPM7), along with the closely related TRPM6, are unique channels that have dual operations: cation permeability and kinase activity. In contrast to the limited tissue distribution of TRPM6, TRPM7 is widely expressed among tissues and is therefore implicated in a variety of cellular functions physiologically and pathophysiologically. The discovery of TRPM7’s unique structure imparting dual ion channel and kinase activities shed light onto novel and peculiar biological functions, such as Mg2+ homeostasis, cellular Ca2+ flickering, and even intranuclear transcriptional regulation by a cleaved kinase domain translocated to nuclei. Interestingly, at a higher level, TRPM7 participates in several biological processes in the nervous and cardiovascular systems, in which excitatory responses in neurons and cardiomyocytes are critical for their function. Here, we review the roles of TRPM7 in cells involved in the nervous and cardiovascular systems and discuss its potential as a future therapeutic target.

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