Kynurenine Modulates MMP-1 and Type-I Collagen Expression Via Aryl Hydrocarbon Receptor Activation in Dermal Fibroblasts

2016 ◽  
Vol 231 (12) ◽  
pp. 2749-2760 ◽  
Author(s):  
Malihe-Sadat Poormasjedi-Meibod ◽  
Sanam Salimi Elizei ◽  
Victor Leung ◽  
Reza Baradar Jalili ◽  
Frank Ko ◽  
...  
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Type I Collagen ◽  
Receptor Activation ◽  
Dermal Fibroblasts ◽  
Type I ◽  
Collagen Expression ◽  
Aryl Hydrocarbon

Up-regulated type I collagen expression by the inhibition of Rac1 signaling pathway in human dermal fibroblasts

2010 ◽  
Vol 393 (1) ◽  
pp. 101-105 ◽  
Author(s):  
Toshikatsu Igata ◽  
Masatoshi Jinnin ◽  
Takamitsu Makino ◽  
Chikako Moriya ◽  
Faith C. Muchemwa ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Type I Collagen ◽  
Dermal Fibroblasts ◽  
Type I ◽  
Human Dermal Fibroblasts ◽  
Collagen Expression

scholarly journals TGF-β–Mediated Downregulation of MicroRNA-196a Contributes to the Constitutive Upregulated Type I Collagen Expression in Scleroderma Dermal Fibroblasts

2012 ◽  
Vol 188 (7) ◽  
pp. 3323-3331 ◽  
Author(s):  
Noritoshi Honda ◽  
Masatoshi Jinnin ◽  
Ikko Kajihara ◽  
Takamitsu Makino ◽  
Katsunari Makino ◽  
...  
Keyword(s):  
Type I Collagen ◽  
Dermal Fibroblasts ◽  
Type I ◽  
Collagen Expression

scholarly journals Ursodeoxycholic Acid May Inhibit Environmental Aging-Associated Hyperpigmentation

Antioxidants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 267
Author(s):  
Ik Jun Moon ◽  
Hanju Yoo ◽  
Seung Hwan Paik ◽  
Hak Tae Kim ◽  
Su Yeon Kim ◽  
...  
Keyword(s):  
Ursodeoxycholic Acid ◽  
Type I Collagen ◽  
Uv Light ◽  
Antioxidant Properties ◽  
Dermal Fibroblasts ◽  
Cellular Aging ◽  
Type I ◽  
Intracellular Signals ◽  
Environmental Aging ◽  
Normal Human

Extrinsic aging of the skin caused by ultraviolet (UV) light or particulate matter is often manifested by hyperpigmentation due to increased melanogenesis in senescent skin. Ursodeoxycholic acid (UDCA), which has been commonly used as a health remedy for liver diseases, is known to possess antioxidant properties. This study was done to investigate whether UDCA inhibits cellular aging processes in the cells constituting human skin and it reduces melanin synthesis. ROS, intracellular signals, IL-1α, IL-8, TNF-α, cyclooxygenase (COX)-2, type I collagen, and matrix metalloproteinases (MMPs) levels were measured in human dermal fibroblasts treated with or without UDCA after UV exposure. Melanin levels and mechanistic pathways for melanogenesis were investigated. UDCA decreased ROS, senescence-associated secretory phenotype (SASP), and proinflammatory cytokines induced by UV treatment. UDCA reduced melanogenesis in normal human melanocytes cocultured with skin constituent cells. Our results suggest that UDCA could be a comprehensive agent for the treatment of environmental aging-associated hyperpigmentation disorders.

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