scholarly journals IL‐1β Promotes Malignant Transformation and Tumor Aggressiveness in Oral Cancer

2014 ◽  
Vol 230 (4) ◽  
pp. 875-884 ◽  
Author(s):  
Chia‐Huei Lee ◽  
Jeffrey Shu‐Ming Chang ◽  
Shih‐Han Syu ◽  
Thian‐Sze Wong ◽  
Jimmy Yu‐Wai Chan ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Malignant Transformation ◽  
Tumor Aggressiveness

scholarly journals An Update on Precancerous Lesions of Oral Cavity

2018 ◽  
Vol 2 (1) ◽  
pp. 70 ◽  
Author(s):  
Deepak Goyal ◽  
Pardeep Goyal ◽  
Harkanwal Preet Singh ◽  
Chanchal Verma
Keyword(s):  
Head And Neck Cancer ◽  
Survival Rate ◽  
High Risk ◽  
Oral Cancer ◽  
Malignant Transformation ◽  
Death Rate ◽  
Precancerous Lesions ◽  
Correct Diagnosis ◽  
Premalignant Lesions ◽  
Timely Treatment

Oral cancer is the most common head and neck cancer, found in 270,000 patients annually worldwide. Some cancers develop from precancerous lesions; however, there is no definitive clinico pathological factor or biomarker that reliably enables malignant transformation to be predicted in an individual patient. Early detection and early treatment of oral cancer are important for improving the survival rate of patients; prevention of oral cancer will clearly contribute most to decreasing its death rate. So correct diagnosis and timely treatment of premalignant lesions with high risk of malignant transformation may help to prevent malignant transformation.

Assessment and Comparison of Salivary Survivin Biomarker in Oral Leukoplakia, Oral Lichen Planus, and Oral Cancer: A Comparative Study

2017 ◽  
Vol 8 (2) ◽  
pp. 73-76 ◽  
Author(s):  
Ruchika Garg ◽  
Arvind V Shetti ◽  
Anjana S Bagewadi
Keyword(s):  
Oral Cancer ◽  
Comparative Study ◽  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Oral Leukoplakia ◽  
Control Group ◽  
Significant Difference ◽  
Potentially Malignant ◽  
Oral Lichen

ABSTRACT Introduction Oral squamous cell carcinoma (OSCC) is the most common malignant tumor of the oral cavity. It is preceded by various potentially malignant conditions like oral leukoplakia and oral lichen planus. Survivin is an inhibitor of apoptosis whose levels have been found increased in oral cancer as well as various potentially malignant conditions. Thus survivin can act as a biomarker and help in early detection of potentially malignant conditions which can prevent its transformation into malignancy. Aim To assess and compare the level of total human salivary survivin in oral leukoplakia, oral lichen planus, oral cancer, and control group. Materials and methods A total of 96 subjects were included in the study, which were further grouped into 24 in each group. The saliva was analyzed for survivin level among all the four groups. Survivin concentration (pg/mL) was studied in relation to clinical data. The results were analyzed using Mann—Whitney U test to derive the statistical difference. Results The average of levels of survivin in control group was 0.199 pg/mL, in oral leukoplakia group 0.312 pg/mL, in oral lichen planus group 0.380 pg/mL, and in oral cancer group 0.430 pg/mL. A comparison of all these groups revealed statistically significant difference among the groups. Conclusion Survivin may not be considered as an independent predictor of the malignant transformation for premalignant lesions but it can be an indicator for an increased risk of malignant transformation. How to cite this article Garg R, Shetti AV, Bagewadi AS. Assessment and Comparison of Salivary Survivin Biomarker in Oral Leukoplakia, Oral Lichen Planus, and Oral Cancer: A Comparative Study. World J Dent 2017;8(2):73-76.

scholarly journals Cordycepin and a preparation from Cordyceps militaris inhibit malignant transformation and proliferation by decreasing EGFR and IL-17RA signaling in a murine oral cancer model

Oncotarget ◽  
2017 ◽  
Vol 8 (55) ◽  
pp. 93712-93728 ◽  
Author(s):  
Peng-Yang Hsu ◽  
Yueh-Hsin Lin ◽  
Erh-Ling Yeh ◽  
Hui-Chen Lo ◽  
Tai-Hao Hsu ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Malignant Transformation ◽  
Cordyceps Militaris ◽  
Cancer Model

Effects of APE1 Asp148Glu polymorphisms on OPMD malignant transformation, and on susceptibility to and overall survival of oral cancer in Taiwan

Head & Neck ◽  
2019 ◽  
Vol 41 (6) ◽  
pp. 1557-1564 ◽  
Author(s):  
Hsin‐I Huang ◽  
Chung‐Ho Chen ◽  
Sheng‐Hung Wang ◽  
Li‐Hsuan Wang ◽  
Ying‐Chu Lin
Keyword(s):  
Overall Survival ◽  
Oral Cancer ◽  
Malignant Transformation ◽  
Ape1 Asp148glu

Molecular Biology of Human Oral Cancer

1996 ◽  
Vol 7 (4) ◽  
pp. 319-328 ◽  
Author(s):  
D.T.W. Wong ◽  
R. Todd ◽  
T. Tsuji ◽  
R.B. Donoff
Keyword(s):  
Cancer Research ◽  
Oral Cancer ◽  
Tumor Suppressor ◽  
Molecular Biology ◽  
Malignant Transformation ◽  
Tumor Suppressor Genes ◽  
Human Cancer ◽  
Transformation Process ◽  
Current Status ◽  
Cellular Genes

The application of molecular biological tools to the study of cancer has significantly advanced the field of human cancer research. Such study has demonstrated the involvement of two classes of highly conserved cellular genes in the malignant transformation process: oncogenes and tumor suppressor genes. Despite these advances in the molecular biology of human cancers, our understanding of human oral cancer lags behind that of cancer of other body sites. This review attempts to assess the current status of the molecular biology of human oral cancer.

scholarly journals Modulating Cancer Progression from Leukoplakia via Bayesian Gene Networks

2021 ◽  
Author(s):  
Alessandro Villa DDS ◽  
Amin Zollanvari
Keyword(s):  
Oral Cancer ◽  
Malignant Transformation ◽  
Cancer Progression ◽  
Gene Networks ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Data Driven ◽  
Data Driven Approach ◽  
Potentially Malignant

Oral squamous cell carcinoma often arises from an oral potentially malignant disorder called oral leukoplakia (OL). With this work we aimed to develop a novel data-driven predictive model based on gene expression profiles to distinguish OL patients who underwent malignant transformation from those who did not. We used the Tree Augmented Naïve (TAN) Bayes classifier to predict the posterior probability of having oral cancer given the data. 86 patients were included with a median follow-up of 7.11 years. Fifty-one patients (51/86; 59%) underwent malignant transformation. We found that 16 genes were predictors of oral cancer in patients with OL and these included SLC7A11, SPINK6, SERPINA12, VIT, ATP1B3, CST6, FLRT2, ELMOD1, AZGP1, RNASE13, DIO2, ECM1, CYP4F11, SYTL4, AKR1C1, and AKR1C3. In conclusion, we showed that Bayesian gene networks are a data-driven approach which could be used also in other predictor models in oncology.

scholarly journals Risk of Malignant Transformation in 3173 Subjects with Histopathologically Confirmed Oral Lichen Planus: A 33-Year Cohort Study in Northern Italy

Cancers ◽  
2021 ◽  
Vol 13 (22) ◽  
pp. 5740
Author(s):  
Paolo G. Arduino ◽  
Alessandro Magliano ◽  
Alessio Gambino ◽  
Alessandra Macciotta ◽  
Mario Carbone ◽  
...  
Keyword(s):  
Cohort Study ◽  
Oral Cancer ◽  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Northern Italy ◽  
Elderly Subjects ◽  
Histopathological Diagnosis ◽  
Oral Lichen

Background: Oral lichen planus (OLP) is considered an oral potentially malignant disorder. The aim of our study was to estimate the risk for oral cancer in patients diagnosed with OLP. Methods: A population-based cohort study between January 1988 and December 2020 at one hospital in Northern Italy was performed. The primary endpoint of the study was that of the histopathological diagnosis of oral cancer during the follow-up period. Results: The study population comprised 3173 patients. During the follow-up period, 32 men and 50 women developed an oral squamous cell carcinoma (2.58%), with a mean time of 103.61 months after the initial diagnosis of OLP, and 21 patients died because of oral cancer. Almost half of the deceased patients had the last follow-up visit before cancer diagnosis in a period of more than 12 months. Older age, having a red form of OLP and fewer sites of involvement, increased the risk of having cancer, while age and no treatment increased the risk of death. Conclusion: This is the largest group of OLP patients with such a long follow up ever reported. Due to the increased risk of having a malignant transformation, especially in elderly subjects, OLP patients should be regularly followed up, particularly in the Northern Italian population.

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