IGF-1 Alleviates NMDA-Induced Excitotoxicity in Cultured Hippocampal Neurons Against Autophagy via the NR2B/PI3K-AKT-mTOR Pathway

2014 ◽  
Vol 229 (11) ◽  
pp. 1618-1629 ◽  
Author(s):  
Yansong Wang ◽  
Wei Wang ◽  
Dongguo Li ◽  
Mi Li ◽  
Peipei Wang ◽  
...  
Keyword(s):  
Hippocampal Neurons ◽  
Mtor Pathway ◽  
Cultured Hippocampal Neurons

scholarly journals Dihydrotestosterone activates CREB signaling in cultured hippocampal neurons

2009 ◽  
Vol 1298 ◽  
pp. 1-12 ◽  
Author(s):  
Thuy-Vi V. Nguyen ◽  
Mingzhong Yao ◽  
Christian J. Pike
Keyword(s):  
Hippocampal Neurons ◽  
Cultured Hippocampal Neurons

scholarly journals Neural cell adhesion molecule promotes accumulation of TGN organelles at sites of neuron-to-neuron contacts

2002 ◽  
Vol 159 (4) ◽  
pp. 649-661 ◽  
Author(s):  
Vladimir Sytnyk ◽  
Iryna Leshchyns'ka ◽  
Markus Delling ◽  
Galina Dityateva ◽  
Alexander Dityatev ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Hippocampal Neurons ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Neural Cell ◽  
Initial Contact ◽  
Neural Cell Adhesion ◽  
Intracellular Organelles ◽  
Cultured Hippocampal Neurons

Transformation of a contact between axon and dendrite into a synapse is accompanied by accumulation of the synaptic machinery at this site, being delivered in intracellular organelles mainly of TGN origin. Here, we report that in cultured hippocampal neurons, TGN organelles are linked via spectrin to clusters of the neural cell adhesion molecule (NCAM) in the plasma membrane. These complexes are translocated along neurites and trapped at sites of initial neurite-to-neurite contacts within several minutes after initial contact formation. The accumulation of TGN organelles at contacts with NCAM-deficient neurons is reduced when compared with wild-type cells, suggesting that NCAM mediates the anchoring of intracellular organelles in nascent synapses.

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