The ZnR/GPR39 Interacts With the CaSR to Enhance Signaling in Prostate and Salivary Epithelia

2014 ◽  
Vol 229 (7) ◽  
pp. 868-877 ◽  
Author(s):  
Hila Asraf ◽  
Shimrit Salomon ◽  
Andrey Nevo ◽  
Israel Sekler ◽  
Doris Mayer ◽  
...  
Keyword(s):  
Salivary Epithelia

Expression of keratin mRNAS and proteins in normal salivary epithelia and pleomorphic adenomas

1993 ◽  
Vol 171 (3) ◽  
pp. 173-181 ◽  
Author(s):  
Lan Su ◽  
Peter R. Morgan ◽  
Dolores L. Harrison ◽  
Ahmad Waseem ◽  
E. Birgitte Lane
Keyword(s):  
Pleomorphic Adenomas ◽  
Salivary Epithelia

scholarly journals Basal lamina of embryonic salivary epithelia. Production by the epithelium and role in maintaining lobular morphology.

1977 ◽  
Vol 73 (2) ◽  
pp. 445-463 ◽  
Author(s):  
S D Banerjee ◽  
R H Cohn ◽  
M R Bernfield
Keyword(s):  
Basal Lamina ◽  
Free Medium ◽  
Normal Morphology ◽  
Selective Degradation ◽  
Cellular Architecture ◽  
Salivary Epithelia ◽  
Testicular Hyaluronidase ◽  
Chondroitin Sulfate A ◽  
Cellular Alterations

The role of the basal lamina in maintaining the normal morphology of mouse embryo submandibular epithelia was assessed by examining its production as well as the cellular and organ culture changes associated with its removal and replacement. The lamina was removed from epithelia isolated free of mesenchyme by brief treatment with testicular hyaluronidase in the absence of calcium. The treatment causes rounding-up of the cells, loss of cellular cohesion, appearance of microvilli, and changes in the organization of cytoskeletal structures. The lamina is not removed and the cellular alterations do not occur in the absence of hyaluronidase in calcium-free medium or when both enzyme and calcium are present, possibly because digestion of chondroitin sulfate, a component of the lamina, is inhibited by calcium. Within 2 h after treatment, in the absence of mesenchyme or biological substrata, the epithelia deposits a new lamina, which is identical by several criteria to the preexisting lamina, and reverses the cellular alterations. Epithelia treated with hyaluronidase lose lobular morphology during culture with mesenchyme. Delaying culture with mesenchyme, to allow restoration of the lamina and of normal cellular architecture, prevents the loss of lobular morphology. The results indicate that the basal lamina imposes morphologic stability on the epithelium, while the mesenchyme apparently affects processes involved in changes in morphology, possibly by selective degradation of the basal lamina.

scholarly journals Gene expression alterations in salivary gland epithelia of Sjögren’s syndrome patients are associated with clinical and histopathological manifestations

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ariana Dela Cruz ◽  
Vinay Kartha ◽  
Andrew Tilston-Lunel ◽  
Rongjuan Mi ◽  
Taylor L. Reynolds ◽  
...  
Keyword(s):  
Gene Expression ◽  
Salivary Gland ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Epithelial Tissue ◽  
Gene Expression Signatures ◽  
Salivary Epithelia ◽  
Sjögren‘S Syndrome

AbstractSjögren’s syndrome (SS) is a complex autoimmune disease associated with lymphocytic infiltration and secretory dysfunction of salivary and lacrimal glands. Although the etiology of SS remains unclear, evidence suggests that epithelial damage of the glands elicits immune and fibrotic responses in SS. To define molecular changes underlying epithelial tissue damage in SS, we laser capture microdissected (LCM) labial salivary gland epithelia from 8 SS and 8 non-SS controls for analysis by RNA sequencing (RNAseq). Computational interrogation of gene expression signatures revealed that, in addition to a division of SS and non-SS samples, there was a potential intermediate state overlapping clustering of SS and non-SS samples. Differential expression analysis uncovered signaling events likely associated with distinct SS pathogenesis. Notable signals included the enrichment of IFN-γ and JAK/STAT-regulated genes, and the induction of genes encoding secreted factors, such as LTF, BMP3, and MMP7, implicated in immune responses, matrix remodeling and tissue destruction. Identification of gene expression signatures of salivary epithelia associated with mixed clinical and histopathological characteristics suggests that SS pathology may be defined by distinct molecular subtypes. We conclude that gene expression changes arising in the damaged salivary epithelia may offer novel insights into the signals contributing to SS development and progression.

scholarly journals Capability of Tissue Stem Cells to Organize into Salivary Rudiments

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Kenji Okumura ◽  
Masanori Shinohara ◽  
Fumio Endo
Keyword(s):  
Stem Cells ◽  
Salivary Gland ◽  
Salivary Glands ◽  
Progenitor Cells ◽  
Duct Cell ◽  
Branching Morphogenesis ◽  
Embryonic Cells ◽  
Gland Development ◽  
Salivary Epithelia ◽  
Pseudoglandular Stage

Branching morphogenesis (BrM), an essential step for salivary gland development, requires epithelial-mesenchymal interactions. BrM is impaired when the surrounding mesenchyme is detached from the salivary epithelium during the pseudoglandular stage. It is believed that the salivary mesenchyme is indispensable for BrM, however, an extracellular matrix gel with exogenous EGF can be used as a substitute for the mesenchyme during BrM in the developing salivary epithelium. Stem/progenitor cells isolated from salivary glands in humans and rodents can be classified as mesenchymal stem cell-like, bone-marrow-derived, duct cell-like, and embryonic epithelium-like cells. Salivary-gland-derived progenitor (SGP) cells isolated from duct-ligated rats, mice, and swine submandibular glands share similar characteristics, including intracellular laminin andα6β1-integrin expression, similar to the embryonic salivary epithelia during the pseudoglandular stage. Progenitor cells also isolated from human salivary glands (human SGP cells) having the same characteristics differentiate into hepatocyte-like cells when transplanted into the liver. Similar to the dissociated embryonic salivary epithelium, human SGP cells aggregate to self-organize into branching organ-like structures on Matrigel plus exogenous EGF. These results suggest the possibility that tissue stem cells organize rudiment-like structures, and the embryonic cells that organize into whole tissues during development are preserved even in adult tissues.

scholarly journals Functional interactions between P2X4and P2X7receptors from mouse salivary epithelia

2009 ◽  
Vol 587 (12) ◽  
pp. 2887-2901 ◽  
Author(s):  
Griselda Casas-Pruneda ◽  
Juan Pablo Reyes ◽  
Gabriela Pérez-Flores ◽  
Patricia Pérez-Cornejo ◽  
Jorge Arreola
Keyword(s):  
Functional Interactions ◽  
Salivary Epithelia
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