Expression of keratin mRNAS and proteins in normal salivary epithelia and pleomorphic adenomas

1993 ◽  
Vol 171 (3) ◽  
pp. 173-181 ◽  
Author(s):  
Lan Su ◽  
Peter R. Morgan ◽  
Dolores L. Harrison ◽  
Ahmad Waseem ◽  
E. Birgitte Lane
Keyword(s):  
Pleomorphic Adenomas ◽  
Salivary Epithelia

Intraluminal crystalloids in malignant salivary gland tumours

1987 ◽  
Vol 101 (11) ◽  
pp. 1175-1181 ◽  
Author(s):  
Jae Y. Ro ◽  
Bruce Mackay ◽  
John G. Batsakis ◽  
Joiner Cartwright
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Parotid Glands ◽  
Salivary Duct ◽  
X Ray ◽  
Salivary Gland Tumours ◽  
Pleomorphic Adenomas

AbstractThe ultrastructural, X-ray microanalytical, histochemical and immunocytochemi-cal features of intraluminal crystalloids found in adenocarcinomas of the parotid gland have been studied. The crystalloids, putatively derived from an abnormal crystalization of salivary duct proteins, are considerably different from the crystalloids found in normal parotid glands, pleomorphic adenomas, and sialocysts.

scholarly journals Canine Mammary Mixed Tumours: A Review

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Geovanni Dantas Cassali ◽  
Angélica Cavalheiro Bertagnolli ◽  
Enio Ferreira ◽  
Karine Araújo Damasceno ◽  
Conrado de Oliveira Gamba ◽  
...  
Keyword(s):  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Malignant Transformation ◽  
Factors Associated ◽  
Histological Types ◽  
Pleomorphic Adenomas ◽  
Mixed Tumours

Mammary mixed tumours are the most frequent neoplasias in female dogs. In humans, mixed tumours are frequently found in the salivary glands and are known as pleomorphic adenomas. In addition to their histomorphologic similarities, mixed tumours and pleomorphic adenomas have the potential to become malignant and give rise to carcinomas in mixed tumours and carcinomas ex-pleomorphic adenoma, respectively. The factors associated with malignant transformation are still poorly known in the case of canine mixed tumours. However, this form of neoplasia tends to be associated with a better prognosis than other malignant histological types. This paper discusses the main features associated with female canine mammary mixed tumours.

Immunolocalization of ??-Catenin in Pleomorphic Adenomas and Carcinomas Ex-pleomorphic Adenomas of Salivary Glands

2007 ◽  
Vol 15 (3) ◽  
pp. 273-278 ◽  
Author(s):  
Marisa C. L. S. Genelhu ◽  
Helenice Gobbi ◽  
Diele C. B. Arantes ◽  
S??rgio V. Cardoso ◽  
Geovanni D. Cassali
Keyword(s):  
Salivary Glands ◽  
Pleomorphic Adenomas

First Insights into the Molecular Basis of Pleomorphic Adenomas of the Salivary Glands

2000 ◽  
Vol 14 (1) ◽  
pp. 81-83 ◽  
Author(s):  
M.L. Voz ◽  
W.J.M. Van de Ven ◽  
K. Kas
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Benign Tumor ◽  
Salivary Gland Tumor ◽  
Transitional Zone ◽  
Chromosome 8 ◽  
Gland Tumor ◽  
Histopathological Classification ◽  
Pleomorphic Adenomas ◽  
Chromosomal Changes

Pleomorphic adenoma, or mixed tumor of the salivary glands, is a benign tumor originating from the major and minor salivary glands. Eighty-five percent of these tumors are found in the parotid gland, 10% in the minor (sublingual) salivary glands, and 5% in the submandibular gland. It is the most common type of salivary gland tumor, accounting for almost 50% of all neoplasms in these organs. In fact, after the first observation of recurrent loss of chromosome 22 in meningioma, this was the second type of benign tumor for which non-random chromosomal changes were reported. The rate of malignant change with the potential to metastasize has been reported to be only 2 to 3%, and only a few cases of metastasizing pleomorphic salivary gland adenomas have been described to date. The fact that these tumors arise in organs located in an ontogenetic transitional zone, a region where endoderm and ectoderm meet, might be one of the reasons for the often-problematic histopathological classification. This type of benign tumor has been cytogenetically very well-characterized, with several hundreds of tumors karyotyped. In addition to the cytogenetic subgroup with an apparently normal diploid stemline (making up approximately 30% of the cases), three major cytogenetic subgroups can be distinguished. In addition to a subgroup showing non-recurrent clonal abnormalities, another subgroup is composed of tumors with various translocations involving 12ql5. By far the largest cytogenetic subgroup, however, consists of tumors with chromosome 8 abnormalities, mainly showing translocations involving region 8ql2. The most frequently encountered aberration in this group is a t(3;8)(p21;q12).

Case of labial sclerosing polycystic adenoma with ductal carcinoma in situ (DCIS)

2021 ◽  
Vol 14 (8) ◽  
pp. e243736
Author(s):  
Soumya Makarla ◽  
Radhika M Bavle ◽  
Reshma Venugopal ◽  
Sudhakara Muniswamappa
Keyword(s):  
Salivary Gland ◽  
Ductal Carcinoma ◽  
Minor Salivary Gland ◽  
Histopathological Diagnosis ◽  
Epithelial Proliferation ◽  
Upper Lip ◽  
Salivary Gland Tumours ◽  
Pleomorphic Adenomas ◽  
Rare Lesion

Minor salivary gland tumours are enigmatic in their behaviour and presentations. Histopathological diagnosis of these tumours encompasses a large spectrum. Conventionally, small nodular tumours of the upper lip or the labial mucosa are generally adenomas, frequently pleomorphic adenomas. Here, we describe a case of a solitary nodular tumour, occurring in the upper labial mucosa, diagnosed as sclerosing polycystic adenoma (SPA) with intraductal epithelial proliferation of high grade. This is a rare lesion, which has entered into the category of salivary gland tumours recently in the 2017 WHO categorisation. We report a case of paucicystic SPA with intraductal epithelial proliferations in the labial minor salivary gland of a 56-year-old woman, which might be the first report of a case occurring in the upper labial mucosa.

Expression of matrix metalloproteinases (MMPs-2, -7, -9, and -26) and tissue inhibitors of metalloproteinases (TIMPs-1 and -2) in pleomorphic adenomas and adenoid cystic carcinomas

2018 ◽  
Vol 275 (12) ◽  
pp. 3075-3082 ◽  
Author(s):  
Valéria Souza Freitas ◽  
Jean Nunes dos Santos ◽  
Pedro Paulo de Andrade Santos ◽  
Cassiano Francisco Weege Nonaka ◽  
Leão Pereira Pinto ◽  
...  
Keyword(s):  
Matrix Metalloproteinases ◽  
Tissue Inhibitors Of Metalloproteinases ◽  
Tissue Inhibitors ◽  
Adenoid Cystic ◽  
Pleomorphic Adenomas

scholarly journals Notch as a Possible Cell Differentiation Factor in Pleomorphic Adenomas

2015 ◽  
Vol 12 (10) ◽  
pp. 759-763 ◽  
Author(s):  
Keisuke Takamine ◽  
Yukiko Ueda ◽  
Keisuke Nakano ◽  
Takanaga Ochiai ◽  
Yoshihiko Sugita ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Differentiation Factor ◽  
Pleomorphic Adenomas ◽  
Cell Differentiation Factor

scholarly journals Inmunohistochemical Expression of PCNA, p53 and bcl-2 in Pleomorphic Adenomas

2008 ◽  
Vol 26 (3) ◽  
Author(s):  
Manuel Antonio Gordón-Núñez ◽  
Gustavo Pina Godoy ◽  
Rosilene Calazans Soares ◽  
Lélia Batista de Souza ◽  
Roseana de Almeida Freitas ◽  
...  
Keyword(s):  
Pleomorphic Adenomas
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