EGFR through STAT3 modulates ΔN63α expression to sustain tumor-initiating cell proliferation in squamous cell carcinomas

2012 ◽  
Vol 228 (4) ◽  
pp. 871-878 ◽  
Author(s):  
Francesca Ripamonti ◽  
Luisa Albano ◽  
Anna Rossini ◽  
Serena Borrelli ◽  
Sonia Fabris ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Tumor Initiating Cell

scholarly journals The Significance of the Dysregulation of Canonical Wnt Signaling in Head and Neck Squamous Cell Carcinomas

Cells ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 723 ◽  
Author(s):  
Jarosław Paluszczak
Keyword(s):  
Cell Proliferation ◽  
Head And Neck Cancer ◽  
Wnt Signaling ◽  
Head And Neck ◽  
Neck Cancer ◽  
Squamous Cell ◽  
Wnt Signaling Pathway ◽  
Squamous Cell Carcinomas ◽  
Canonical Wnt Signaling ◽  
Canonical Wnt

The knowledge about the molecular alterations which are found in head and neck squamous cell carcinomas (HNSCC) has much increased in recent years. However, we are still awaiting the translation of this knowledge to new diagnostic and therapeutic options. Among the many molecular changes that are detected in head and neck cancer, the abnormalities in several signaling pathways, which regulate cell proliferation, cell death and stemness, seem to be especially promising with regard to the development of targeted therapies. Canonical Wnt signaling is a pathway engaged in the formation of head and neck tissues, however it is not active in adult somatic mucosal cells. The aim of this review paper is to bring together significant data related to the current knowledge on the mechanisms and functional significance of the dysregulation of the Wnt/β-catenin pathway in head and neck tumors. Research evidence related to the role of Wnt signaling activation in the stimulation of cell proliferation, migration and inhibition of apoptosis in HNSCC is presented. Moreover, its role in promoting stemness traits in head and neck cancer stem-like cells is described. Evidence corroborating the hypothesis that the Wnt signaling pathway is a very promising target of novel therapeutic interventions in HNSCC is also discussed.

MicroRNA-492 overexpression involves in cell proliferation, migration, and radiotherapy response of cervical squamous cell carcinomas

2017 ◽  
Vol 57 (1) ◽  
pp. 32-43 ◽  
Author(s):  
Mei Liu ◽  
Jusheng An ◽  
Manni Huang ◽  
Liming Wang ◽  
Binbin Tu ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas

Activation of ERK1/2 and cyclin D1 expression in oral tongue squamous cell carcinomas: Relationship between clinicopathological appearances and cell proliferation

Oral Oncology ◽  
2006 ◽  
Vol 42 (6) ◽  
pp. 625-631 ◽  
Author(s):  
Lihong Wang ◽  
Tingjiao Liu ◽  
Mai Nishioka ◽  
Rodelio L. Aguirre ◽  
Swe Swe Win ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cyclin D1 ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Oral Tongue
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