Modulation of Tumor Cell Proliferation and Apoptosis by Polyamine Depletion in Cells of Head and Neck Squamous Cell Carcinomas

1999 ◽  
Vol 152 (6) ◽  
pp. 604 ◽  
Author(s):  
Jonathan M. Bock ◽  
Michael A. Pickart ◽  
John J. Pink ◽  
Paul M. Harari
Keyword(s):  
Cell Proliferation ◽  
Tumor Cell ◽  
Head And Neck ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Tumor Cell Proliferation ◽  
Proliferation And Apoptosis ◽  
In Cells

Mutation of p53 in Squamous Cell Cancer of the Head and Neck: Relationship to Tumor Cell Proliferation

1997 ◽  
Vol 107 (6) ◽  
pp. 827-833 ◽  
Author(s):  
Nancy B. Wood ◽  
Valery Kotelnikov ◽  
David D. Caldarelli ◽  
James Hutchinson ◽  
William R. Panje ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Tumor Cell ◽  
Head And Neck ◽  
Squamous Cell ◽  
Squamous Cell Cancer ◽  
Cell Cancer ◽  
Tumor Cell Proliferation

Expression of Survivin in Gastric Carcinoma and its Relation to Tumor Cell Proliferation and Apoptosis

2009 ◽  
Vol 43 (4) ◽  
pp. 329 ◽  
Author(s):  
Wan-Sik Lee ◽  
Sung-Bum Cho ◽  
Jong-Sun Rew ◽  
Jae-Hyuk Lee ◽  
Chang-Soo Park ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Gastric Carcinoma ◽  
Tumor Cell ◽  
Tumor Cell Proliferation ◽  
Proliferation And Apoptosis

scholarly journals The Significance of the Dysregulation of Canonical Wnt Signaling in Head and Neck Squamous Cell Carcinomas

Cells ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 723 ◽  
Author(s):  
Jarosław Paluszczak
Keyword(s):  
Cell Proliferation ◽  
Head And Neck Cancer ◽  
Wnt Signaling ◽  
Head And Neck ◽  
Neck Cancer ◽  
Squamous Cell ◽  
Wnt Signaling Pathway ◽  
Squamous Cell Carcinomas ◽  
Canonical Wnt Signaling ◽  
Canonical Wnt

The knowledge about the molecular alterations which are found in head and neck squamous cell carcinomas (HNSCC) has much increased in recent years. However, we are still awaiting the translation of this knowledge to new diagnostic and therapeutic options. Among the many molecular changes that are detected in head and neck cancer, the abnormalities in several signaling pathways, which regulate cell proliferation, cell death and stemness, seem to be especially promising with regard to the development of targeted therapies. Canonical Wnt signaling is a pathway engaged in the formation of head and neck tissues, however it is not active in adult somatic mucosal cells. The aim of this review paper is to bring together significant data related to the current knowledge on the mechanisms and functional significance of the dysregulation of the Wnt/β-catenin pathway in head and neck tumors. Research evidence related to the role of Wnt signaling activation in the stimulation of cell proliferation, migration and inhibition of apoptosis in HNSCC is presented. Moreover, its role in promoting stemness traits in head and neck cancer stem-like cells is described. Evidence corroborating the hypothesis that the Wnt signaling pathway is a very promising target of novel therapeutic interventions in HNSCC is also discussed.

Tumor cell proliferation and apoptosis in medulloblastoma

1994 ◽  
Vol 87 (4) ◽  
pp. 362-370 ◽  
Author(s):  
Davide Schiffer ◽  
Paolo Cavalla ◽  
Adriano Chi� ◽  
Maria Teresa Giordana ◽  
Silvia Marino ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Tumor Cell ◽  
Tumor Cell Proliferation ◽  
Proliferation And Apoptosis
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