scholarly journals Human myxomatous mitral valve prolapse: Role of bone morphogenetic protein 4 in valvular interstitial cell activation

2012 ◽  
Vol 227 (6) ◽  
pp. 2595-2604 ◽  
Author(s):  
Rachana Sainger ◽  
Juan B. Grau ◽  
Emanuela Branchetti ◽  
Paolo Poggio ◽  
William F. Seefried ◽  
...  
Keyword(s):  
Mitral Valve ◽  
Bone Morphogenetic Protein ◽  
Mitral Valve Prolapse ◽  
Cell Activation ◽  
Interstitial Cell ◽  
Bone Morphogenetic Protein 4 ◽  
Morphogenetic Protein

scholarly journals A New Role for the Aldosterone/Mineralocorticoid Receptor Pathway in the Development of Mitral Valve Prolapse

2020 ◽  
Vol 127 (3) ◽  
Author(s):  
Jaime Ibarrola ◽  
Amaia Garcia-Peña ◽  
Lara Matilla ◽  
Benjamin Bonnard ◽  
Rafael Sádaba ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Mitral Valve ◽  
Mitral Valve Prolapse ◽  
Mineralocorticoid Receptor ◽  
Cell Activation ◽  
Cardiac Fibrosis ◽  
Interstitial Cell ◽  
Activation Markers ◽  
Mesenchymal Transition ◽  
Endothelial Mesenchymal Transition

Rationale: Mitral valve prolapse (MVP) is one of the most common valvular disorders. However, the molecular and cellular mechanisms involved in fibromyxomatous changes in the mitral leaflet tissue have not been elucidated. Aldosterone (Aldo) promotes fibrosis in myocardium, and MR (mineralocorticoid receptor) antagonists (MRAs) improve cardiac function by decreasing cardiac fibrosis. Objective: We investigated the role of the Aldo/MR in the fibromyxomatous modifications associated with MVP. Methods and Results: Aldo enhanced valvular interstitial cell activation markers and induced endothelial-mesenchymal transition in valvular endothelial cells, resulting in increased proteoglycan secretion. MRA blocked all the above effects. Cytokine arrays showed CT-1 (cardiotrophin-1) to be a mediator of Aldo-induced valvular interstitial cell activation and proteoglycan secretion and CD (cluster of differentiation) 14 to be a mediator of Aldo-induced endothelial-mesenchymal transition and proteoglycan secretion in valvular endothelial cells. In an experimental mouse model of MVP generated by nordexfenfluramine administration, MRA treatment reduced mitral valve thickness and proteoglycan content. Endothelial-specific MR deletion prevented fibromyxomatous changes induced by nordexfenfluramine administration. Moreover, proteoglycan expression was slightly lower in the mitral valves of MVP patients treated with MRA. Conclusions: These findings demonstrate, for the first time, that the Aldo/MR pathway regulates the phenotypic, molecular, and histological changes of valvular interstitial cells and valvular endothelial cells associated with MVP development. MRA treatment appears to be a promising option to reduce fibromyxomatous alterations in MVP.

The role of bone morphogenetic protein 4 in corneal injury repair

2021 ◽  
pp. 108769
Author(s):  
Huicong Hu ◽  
Shurong Wang ◽  
Yuxi He ◽  
Sitong Shen ◽  
Boyuan Yao ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Bone Morphogenetic Protein 4 ◽  
Corneal Injury ◽  
Injury Repair ◽  
Morphogenetic Protein

scholarly journals Role of Bone morphogenetic protein 4 in zebrafish semicircular canal development

2007 ◽  
Vol 49 (9) ◽  
pp. 711-719 ◽  
Author(s):  
Yasuhiro Omata ◽  
Yasuhiro Nojima ◽  
Satomi Nakayama ◽  
Hitoshi Okamoto ◽  
Harukazu Nakamura ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Semicircular Canal ◽  
Bone Morphogenetic Protein 4 ◽  
Morphogenetic Protein

Regulating the Role of Bone Morphogenetic Protein 4 in Tooth Bioengineering

2007 ◽  
Vol 65 (3) ◽  
pp. 501-507 ◽  
Author(s):  
Il-Hyuk Chung ◽  
Pill-Hoon Choung ◽  
Hyun-Jeong Ryu ◽  
Young-Ho Kang ◽  
Han-Wool Choung ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Bone Morphogenetic Protein 4 ◽  
Morphogenetic Protein

The Role of Bone Morphogenetic Protein 4 in Ovarian Function and Diseases

2021 ◽  
Author(s):  
Dongyong Yang ◽  
Xiao Yang ◽  
Fangfang Dai ◽  
Yanqing Wang ◽  
Yi Yang ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Ovarian Function ◽  
Bone Morphogenetic Protein 4 ◽  
Morphogenetic Protein

scholarly journals Emerging Role of Bone Morphogenetic Protein 4 in Metabolic Disorders

Diabetes ◽  
2021 ◽  
Vol 70 (2) ◽  
pp. 303-312
Author(s):  
Ritesh K. Baboota ◽  
Matthias Blüher ◽  
Ulf Smith
Keyword(s):  
Bone Morphogenetic Protein ◽  
Metabolic Disorders ◽  
Bone Morphogenetic Protein 4 ◽  
Morphogenetic Protein
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