Bone morphogenetic protein 4 inhibits TGF-β2 stimulation of extracellular matrix proteins in optic nerve head cells: Role of gremlin in ECM modulation

Glia ◽  
2009 ◽  
Vol 57 (7) ◽  
pp. 755-766 ◽  
Author(s):  
Gulab S. Zode ◽  
Abbot F. Clark ◽  
Robert J. Wordinger
Keyword(s):  
Extracellular Matrix ◽  
Optic Nerve ◽  
Bone Morphogenetic Protein ◽  
Optic Nerve Head ◽  
Extracellular Matrix Proteins ◽  
Matrix Proteins ◽  
Bone Morphogenetic Protein 4 ◽  
Morphogenetic Protein ◽  
Stimulation Of

scholarly journals Exploring the role of extracellular matrix proteins to develop biomarkers of plaque vulnerability and outcome

2020 ◽  
Vol 287 (5) ◽  
pp. 493-513 ◽  
Author(s):  
S. Holm Nielsen ◽  
L. Jonasson ◽  
K. Kalogeropoulos ◽  
M. A. Karsdal ◽  
A. L. Reese‐Petersen ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Extracellular Matrix Proteins ◽  
Matrix Proteins ◽  
Plaque Vulnerability

Role of high molecular weight extracellular matrix proteins in glioma cell migration

1997 ◽  
Vol 23 (2) ◽  
pp. 102-112 ◽  
Author(s):  
R. Mahesparan ◽  
B. B. Tysnes ◽  
K. Edvardsen ◽  
H. K. Haugeland ◽  
I. Garcia Cabrera ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Extracellular Matrix ◽  
Cell Migration ◽  
High Molecular Weight ◽  
Glioma Cell ◽  
Extracellular Matrix Proteins ◽  
Matrix Proteins ◽  
Glioma Cell Migration

scholarly journals Hyperglycemia Alters the Responsiveness of Smooth Muscle Cells to Insulin-Like Growth Factor-I

Endocrinology ◽  
2007 ◽  
Vol 148 (5) ◽  
pp. 2435-2443 ◽  
Author(s):  
Laura A. Maile ◽  
Byron E. Capps ◽  
Yan Ling ◽  
Gang Xi ◽  
David R. Clemmons
Keyword(s):  
Extracellular Matrix ◽  
Smooth Muscle ◽  
Mapk Pathway ◽  
Extracellular Matrix Proteins ◽  
Matrix Proteins ◽  
Downstream Signaling ◽  
Igf I ◽  
Cell Migration And Proliferation ◽  
Stimulation Of ◽  
In Cells

IGF-I stimulation of smooth muscle cell (SMC) migration and proliferation requires αVβ3 ligand occupancy. We hypothesized that changes in the levels of extracellular matrix proteins induced by alterations in glucose concentrations may regulate the ability of SMCs to respond to IGF-I. IGF-I stimulated migration and proliferation of SMCs that had been maintained in 25 mm glucose containing media, but it had no stimulatory effect when tested using SMCs that had been grown in 5 mm glucose. IGF-I stimulated an increase in Shc phosphorylation and enhanced activation of the MAPK pathway in SMCs grown in 25 mm glucose, whereas in cells maintained in 5 mm glucose, IGF-I had no effect on Shc phosphorylation, and the MAPK response to IGF-I was markedly reduced. In cells grown in 25 mm glucose, the levels of αVβ3 ligands, e.g. osteopontin, vitronectin, and thrombospondin, were all significantly increased, compared with cells grown in 5 mm glucose. The addition of these αVβ3 ligands to SMCs grown in 5 mm glucose was sufficient to permit IGF-I-stimulated Shc phosphorylation and downstream signaling. Because we have shown previously that αVβ3 ligand occupancy is required for IGF-I-stimulated Shc phosphorylation and stimulation of SMC growth, our data are consistent with a model in which 25 mm glucose stimulates increases in the concentrations of these extracellular matrix proteins, thus enhancing αVβ3 ligand occupancy, which leads to increased Shc phosphorylation and enhanced cell migration and proliferation in response to IGF-I.

Transdifferentiation of Bone Marrow Mesenchymal Stem Cells into the Islet-Like Cells: the Role of Extracellular Matrix Proteins

2015 ◽  
Vol 63 (5) ◽  
pp. 377-384 ◽  
Author(s):  
Marta Pokrywczynska ◽  
Marzena Anna Lewandowska ◽  
Sandra Krzyzanowska ◽  
Arkadiusz Jundzill ◽  
Marta Rasmus ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Extracellular Matrix ◽  
Mesenchymal Stem Cells ◽  
Extracellular Matrix Proteins ◽  
Matrix Proteins ◽  
Marrow Mesenchymal Stem Cells
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