Proliferation of rat small hepatocytes requires follistatin expression

2012 ◽  
Vol 227 (6) ◽  
pp. 2363-2370 ◽  
Author(s):  
Hidekazu Ooe ◽  
Qijie Chen ◽  
Junko Kon ◽  
Kazunori Sasaki ◽  
Hiroyuki Miyoshi ◽  
...  
Keyword(s):  
Small Hepatocytes

Coordinated Movement of Bile Canalicular Networks Reconstructed by Rat Small Hepatocytes

2005 ◽  
Vol 33 (5) ◽  
pp. 696-708 ◽  
Author(s):  
Ryo Sudo ◽  
Hiroshi Kohara ◽  
Toshihiro Mitaka ◽  
Mariko Ikeda ◽  
Kazuo Tanishita
Keyword(s):  
Small Hepatocytes

Small hepatocytes in primary cultures

2000 ◽  
pp. 195-208
Author(s):  
Toshihiro Mitaka ◽  
Fumihiko Sato
Keyword(s):  
Primary Cultures ◽  
Small Hepatocytes

Evaluation of coculture model composed of sinusoidal endothelial cells and small hepatocytes

2006 ◽  
Vol 39 ◽  
pp. S586
Author(s):  
H. Asamia ◽  
R. Sudoa ◽  
T. Mitakab ◽  
M. Ikedaa ◽  
K. Tanishitaa
Keyword(s):  
Endothelial Cells ◽  
Sinusoidal Endothelial Cells ◽  
Coculture Model ◽  
Small Hepatocytes

Growth and Maturation of Small Hepatocytes Isolated from Adult Rat Liver

1995 ◽  
Vol 214 (2) ◽  
pp. 310-317 ◽  
Author(s):  
T. Mitaka ◽  
T. Kojima ◽  
T. Mizuguchi ◽  
Y. Mochizuki
Keyword(s):  
Rat Liver ◽  
Adult Rat ◽  
Small Hepatocytes

Morphological estimation for the effects of flow to hepatic organoid formed by rat small hepatocytes

2003 ◽  
Vol 2003.15 (0) ◽  
pp. 287-288
Author(s):  
Toshiyuki Hanawa ◽  
Haruko Sonoyama ◽  
Ryo Sudo ◽  
Toshihiro Mitaka ◽  
Mariko Ikeda ◽  
...  
Keyword(s):  
Small Hepatocytes

Functional expression of organic anion transporters in hepatic organoids reconstructed by rat small hepatocytes

2008 ◽  
Vol 104 (1) ◽  
pp. 68-81 ◽  
Author(s):  
Hideki Oshima ◽  
Junko Kon ◽  
Hidekazu Ooe ◽  
Koichi Hirata ◽  
Toshihiro Mitaka
Keyword(s):  
Organic Anion ◽  
Functional Expression ◽  
Organic Anion Transporters ◽  
Anion Transporters ◽  
Small Hepatocytes

Hepatocellular Injury With Hyperaminotransferasemia After Cresol Ingestion

2003 ◽  
Vol 127 (3) ◽  
pp. 364-366
Author(s):  
Yoshito Kamijo ◽  
Kazui Soma ◽  
Mikio Kokuto ◽  
Makoto Ohbu ◽  
Chiaki Fuke ◽  
...  
Keyword(s):  
Supportive Therapy ◽  
Rapid Onset ◽  
Hepatocellular Injury ◽  
Serum Aminotransferase ◽  
Hydropic Degeneration ◽  
Arterial Circulation ◽  
Small Hepatocytes ◽  
Time Of Admission ◽  
Noxious Effect

Abstract A 42-year-old man attempted suicide by ingesting about 150 mL of a saponated cresol solution containing about 50% cresol. His serum aminotransferase concentrations were elevated, and a coagulopathy was present at the time of admission, 15 hours after ingestion. The hyperaminotransferasemia and coagulopathy worsened on the second day, but resolved thereafter with supportive therapy. Histologic examination of a biopsy specimen obtained on the 14th day demonstrated focal dropout of hepatocytes (which were replaced by reticulin and collagen fibers), ballooning or hydropic degeneration of hepatocytes, and rapid regeneration with small hepatocytes in the periportal zones as well as in the centrilobular zones. A rapid onset of illness with periportal hepatocellular injury is inconsistent with damage due to a hepatotoxic metabolite of p-cresol produced by cytochrome P450, which has been suggested by studies in vitro. A direct transient noxious effect mediated via the portal or arterial circulation may be involved in hepatic injury after cresol ingestion.

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